A5038489569- Plant Molecular Biology Research
- Photosynthetic Processes and Mechanisms
- Lung Cancer Treatments and Mutations
- Plant Stress Responses and Tolerance
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Plant Reproductive Biology
- Nutritional Studies and Diet
- Radiomics and Machine Learning in Medical Imaging
- Plant Gene Expression Analysis
- Cancer Cells and Metastasis
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Fermentation and Sensory Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cosmology and Gravitation Theories
- Pancreatic and Hepatic Oncology Research
- Fatty Acid Research and Health
- Plant and animal studies
- Agriculture, Plant Science, Crop Management
- Turfgrass Adaptation and Management
- Plant nutrient uptake and metabolism
- Fungal and yeast genetics research
National Cancer Center Hospital East
2022-2024
Ehime University
2021-2023
Cambridge University Press
2023
New York University Press
2023
The Graduate University for Advanced Studies, SOKENDAI
2011-2021
National Astronomical Observatory of Japan
2021
Office of Education
2016
National Institute of Genetics
2008-2015
Shizuoka University
2015
Mie University
2012
Vascular plants appeared ~410 million years ago, then diverged into several lineages of which only two survive: the euphyllophytes (ferns and seed plants) lycophytes. We report here genome sequence lycophyte Selaginella moellendorffii (Selaginella), first nonseed vascular plant reported. By comparing gene content in evolutionarily diverse taxa, we found that transition from a gametophyte- to sporophyte-dominated life cycle required far fewer new genes than flowering plant, whereas secondary...
Summary An interesting observation, reported for transgenic plants that have been engineered to overproduce osmolytes, is they often exhibit impaired growth in the absence of stress. As reduction and accumulation osmolytes both typically result from adaptation, we hypothesized may actually osmolyte accumulation. To examine this possibility more closely, intracellular proline level was manipulated by expressing mutated derivatives tomPRO2 (a Δ 1 ‐pyrroline‐5‐carboxylate synthetase, P5CS,...
Histone modification in chromatin is one of the key control points gene regulation eukaryotic cells. Protein complexes composed histone acetyltransferase or deacetylase, WD40 repeat protein, and many other components have been implicated this process. Here, we report identification functional characterization HOS15, a WD40-repeat protein crucial for repression genes associated with abiotic stress tolerance through deacetylation Arabidopsis . HOS15 shares high sequence similarity human...
P-glycoprotein (P-gp/MDR1) is a multispecific efflux transporter regulating the pharmacokinetics of various drugs. Although P-gp expression in small intestine elevated after liver ischemia-reperfusion (I/R) injury, regulatory mechanism remains to be clarified. MicroRNAs (miRNAs) play an important role post-transcriptional regulation drug transporters. Here, we investigated intestinal profile miRNAs I/R and epithelial cells. Microarray analysis showed that microRNA-145 (miR-145) level was...
The molecular mechanism for meiotic entry remains largely elusive in flowering plants. Only Arabidopsis SWI1/DYAD and maize AM1, both of which are the coiled-coil protein, known to be required initiation plant meiosis. underlying synchrony male meiosis, characteristic plants, has also been unclear kingdom. In other eukaryotes, RNA-recognition-motif (RRM) proteins play essential roles germ-cell development meiosis progression. Rice MEL2 protein discovered this study shows partial similarity...
Ultra-light axions are hypothetical scalar particles that influence the evolution of large-scale structures Universe. Depending on their mass, they can potentially be part dark matter component Universe, as candidates commonly referred to fuzzy matter. While strong constraints have been established for pure models, more general scenario where ultra-light constitute only a fraction has limited few observational probes. In this work, we use galaxy cluster number counts obtained from first...
We report a role for the Arabidopsis (Arabidopsis thaliana) RESURRECTION1 (RST1) gene in plant defense. The rst1 mutant exhibits enhanced susceptibility to biotrophic fungal pathogen Erysiphe cichoracearum but resistance necrotrophic pathogens Botrytis cinerea and Alternaria brassicicola. RST1 encodes novel protein that localizes plasma membrane is predicted contain 11 transmembrane domains. Disease responses correlate with higher levels of jasmonic acid (JA) increased basal B....
Summary Cleistogamy is a mating system found in approximately 300 species of flowering plants. Cleistogamous plants produce closed (cleistogamous, CL) flowers that require obligate self‐pollination and open (chasmogamous, CH) allow for outcross‐pollination. CL CH are induced by various environmental factors; this appears to be an adaptive strategy unpredictable environments. We examined the molecular basis Cardamine kokaiensis , which closely related model plant Arabidopsis thaliana . should...
Abstract Aim Dirty necrosis (DN) in renal cell carcinoma (RCC) is morphologically characterized by abundant neutrophil infiltration and has significant potential as an unfavorable prognostic indicator. This study aimed to analyze the pathological biological features of DN. Materials Methods A total 81 RCC tumors, including 33 cases DN 48 tumor without (ghost [GN]), were enrolled this study. We compared number neutrophils; activation death pathways, ferroptosis, NETosis, apoptosis; rate...
Abstract The area of residual tumor (ART) is a prognostic factor in patients treated with neoadjuvant chemotherapy (NAC) for lung, pancreatic, and rectal cancers. This study aimed to evaluate the usefulness ART as method predicting prognosis triple‐negative breast cancer (TNBC) after NAC. We included 143 TNBC at maximum cut surface was measured. divided into three groups: ART‐0 (ART = 0 mm 2 ), ART‐low (0 < ≤ 136mm ART‐high > 136 compared their clinicopathologic factors prognosis....
The prognostic significance and role of extratumoral alveolar macrophages (exAMs) in lung adenocarcinoma (LUAD) patients remain unknown. In this study, we investigated the impact gene expression exAMs LUAD patients. density (AMs) peri-tumoral field (p-exAMs) distant (d-exAMs) was evaluated 217 with lymph node metastasis. Patients high p-exAMs showed significantly shorter recurrence-free (RFS) overall survival (OS) than those low (p = 0.02 p 0.03, respectively), whereas there no difference...
Positron emission tomography is a useful technique for diagnosing lymph node (LN) metastasis. This study aimed to elucidate the association between fluorodeoxyglucose accumulation and microenvironment in metastatic LNs lung adenocarcinoma. We retrospectively analyzed 62 patients with surgically resected pathological N2 adenocarcinoma who underwent preoperative PET. The maximum standardized uptake value (SUVmax ) was measured. Lymph specimens were immunohistochemically CD8+ , FoxP3+ CD79a+...
This study aimed to identify patients with upper urinary tract urothelial carcinoma (UTUC) having potential Lynch syndrome (pLS) by immunohistochemistry (IHC) of DNA mismatch repair gene-related proteins (MMRPs) and Amsterdam criteria II explore their clinical characteristics.We retrospectively collected the data 150 consecutive UTUC who underwent surgical resection at our institution between February 2012 December 2020, four MMRPs (MLH1, MSH2, MSH6, PMS2) on all specimens was performed....
Dirty necrosis (DN) is a form of tumor (TN) with prominent neutrophil infiltration and cell detritus in the necrotic foci. This study aimed to characterize clinicopathological features DN metastatic lung cancers colon rectum (MLCRs). A total 227 patients who underwent pulmonary metastasectomy complete resection for MLCR were included this study. TN was evaluated using digitally scanned specimens. These slides immunostained biomarkers NETosis (citrullinated histone H3 [citH3] myeloperoxidase...
We investigated the adaptation to oxidative stress by Saccharomyces cerevisiae strains existing in spatial proximity but contrasting climatic niches, monitoring gene expression responses entire S. genome. Strains were isolated from different locations along a microclimatic gradient at 'Evolution Canyon' (EC), Mt Carmel, Israel. Selected 17 canyon's 'African' south-facing slope (SFS), characterized xeric conditions and high irradiation, 19 'European' north-facing (NFS), mesic low six valley...