A5101410557- Lung Cancer Research Studies
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Urinary and Genital Oncology Studies
- Radiomics and Machine Learning in Medical Imaging
- Thyroid Cancer Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Diet and metabolism studies
- S100 Proteins and Annexins
- Microfluidic and Bio-sensing Technologies
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
Keio University
2000-2025
Osaka University
2025
St. Marianna University School of Medicine
2024
Kushiro Rosai Hospital
2024
Chiba University
2000-2024
National Cancer Center Hospital East
2016-2023
Tokyo National Hospital
2023
Shizuoka Cancer Center
2008-2017
University of Niigata Prefecture
2016-2017
National Cancer Center
2016-2017
Background Epithelial cell adhesion molecule (EpCAM)-based enumeration of circulating tumor cells (CTC) has prognostic value in patients with solid tumors, such as advanced breast, colon, and prostate cancer. However, poor sensitivity been reported for non-small lung cancer (NSCLC). To address this problem, we developed a microcavity array (MCA) system integrated miniaturized device CTC isolation without relying on EpCAM expression. Here, report the results clinical study CTCs which compared...
Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor in adults with a 5-year overall survival rate of less than 10%. Podoplanin (PDPN) type I transmembrane mucin-like glycoprotein, expressed lymphatic endothelium. Several solid tumors overexpress PDPN, including mesenchymal GBM, which has been reported to present worst prognosis among GBM subtypes. Chimeric antigen receptor (CAR)-transduced T cells can recognize predefined surface antigens independent MHC...
Hepatic veno-occlusive disease (VOD) is a common transplant-related complication of stem cell transplantation. There no safe and proven therapy for established VOD, attempts have focused on its prevention. Limited studies suggested that prophylactic use ursodeoxycholic acid (UDCA) reduced the incidence VOD. To confirm preventive effect UDCA we conducted prospective, unblinded randomized, multicenter study involving 132 patients who underwent transplantation variety disorders. Sixty-seven...
Signal transducer and activator of transcription (STAT) 3, a member family DNA-binding molecules, is potential target in the treatment cancer. The highly phosphorylated STAT3 cancer cells contributes to numerous physiological oncogenic signaling pathways. Furthermore, significant association between glioblastoma multiforme stem-like cell (GBM-SC) development maintenance has been demonstrated recent studies. Previously, we reported novel small molecule inhibitor dimerization, STX-0119, as...
High-grade gliomas including glioblastoma multiforme (GBM) are among the most malignant and aggressive of tumors, have a very poor prognosis despite temozolomide-based intensive treatment. Therefore, novel therapeutic approach to controlling recurrence is needed. In present study, we investigated effect activated dendritic cell (DC) (α-type-1 polarized DC)-based immunotherapy on high-grade glioma patients with HLA-A2 or A24 genotype. Nine recurrent 7 GBMs who fulfilled eligibility criteria...
Undifferentiated sarcoma harboring the BCOR-CCNB3 fusion is characterized by its predilection to affect skeletons of adolescent males, cellular small round/spindle cell morphology, and CCNB3 immunoreactivity. We analyzed 11 cases sarcoma, 10 which were identified in a reverse transcription-polymerase chain reaction–based screen 85 patient samples recorded our database as unclassified round or spindle sarcomas. BCOR rearrangements confirmed fluorescence situ hybridization 8 tumors. All...
Abstract The SWI/SNF chromatin-remodeling complex that comprises multiple subunits orchestrates diverse cellular processes, including gene expression, DNA repair, and replication, by sliding releasing nucleosomes. AT-interacting domain-rich protein 1A (ARID1A) ARID1B (ARID1A/B), a pivotal subunit, have significant relevance in cancer management because they are frequently mutated broad range of types. To delineate the network involving ARID1A/B, we investigated interactions this with other...
Recent gene expression and copy number profilings of glioblastoma multiforme (GBM) by The Cancer Genome Atlas (TCGA) Research Network suggest the existence distinct subtypes this tumor. However, these approaches might not be easily applicable in routine clinical practice. In current study, we aimed to establish a proteomics-based subclassification GBM integrating their genomic epigenomic profiles. We subclassified 79 newly diagnosed based on patterns determined comprehensive...
Abstract Sarcomatoid hepatocellular carcinoma (SHCC), which was a rare histological subtype of (HCC), is currently subclassified as poorly differentiated HCC because insufficient evidence to define SHCC HCC. We aimed assess the feasibility classifying by comprehensively identifying novel and distinct characteristics compared ordinary (OHCC). Fifteen SHCCs (1.4%) defined with at least 10% sarcomatous component, 15 randomly disease‐stage‐matched OHCCs 163 consecutive were extracted from 1106...
Small-cell lung carcinoma (SCLC) and large-cell neuroendocrine (LCNEC) are categorized as high-grade tumours because of their poor prognosis compared with those other the lung. There have been no clinicopathological studies focusing on small-sized tumours. We analysed features peripheral, retrospectively. A total 28 patients (maximum diameter 3.0 cm) SCLC LCNEC underwent surgical resection in our hospital were enrolled this study. Of tumours, 18 10 LCNEC. In terms serum tumour marker levels,...
Somatic mutations in BRAF, especially BRAFV600E, are frequently identified papillary thyroid cancer (PTC) tumors. It has been established that expression levels of numbers genes characteristically altered PTC, however, the link between BRAF mutation and gene patterns still elusive. In present study, we analyzed relative wild type BRAFV600E mRNA by using quantitative PCR (qPCR) cDNAPCR- RFLP 19 PTC specimens adjacent normal tissues. was detected 17 out specimens, were valuable among...
Background: More than 80% of all thyroid cancers, the most common endocrine malignancy, are papillary cancer (PTC). It is well established that CITED1 (Cbp/p300 Interacting Transactivators with glutamic acid [E] and aspartic [D]-rich C-terminal domain) mRNA characteristically overexpressed in PTC. Our previous study suggested a positive association BRAF mutation overexpression. However, mechanism expression PTC remains to be elucidated. In present study, we analyzed whether aberrant...
Abstract Ectopic meningioma is a generally rare type of benign tumor that very rarely occurs in the lung. Here, we report cytological findings primary pulmonary with particular focus on immunohistochemical (IHC) assessment. A healthy 60‐year‐old woman visited our hospital an asymptomatic nodule right lower lung lobe. She had no past‐history and other tumors central nervous system or elsewhere according to imaging examination. Transbronchial fine‐needle aspiration cytology revealed clusters...