A5043077578- Parasites and Host Interactions
- Global Maternal and Child Health
- Neuroendocrine Tumor Research Advances
- Child Nutrition and Water Access
- Parasite Biology and Host Interactions
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- Gastrointestinal disorders and treatments
- Bacillus and Francisella bacterial research
- Actinomycetales infections and treatment
- Poxvirus research and outbreaks
- Biliary and Gastrointestinal Fistulas
- Cancer-related gene regulation
- Helminth infection and control
- Research on Leishmaniasis Studies
- Menopause: Health Impacts and Treatments
- Pancreatitis Pathology and Treatment
- Birth, Development, and Health
- Global Health and Surgery
- Urban Transport and Accessibility
- Menstrual Health and Disorders
- S100 Proteins and Annexins
- Viral Infections and Outbreaks Research
- TGF-β signaling in diseases
Nagasaki University
2020-2025
The University of Tokyo
2021-2024
National Institute of Infectious Diseases
2023-2024
Nagoya University
2009-2011
Nagoya University Hospital
2009
Meitetsu Hospital
2001-2005
Background Schistosoma haematobium is the causative pathogen for urogenital schistosomiasis. To achieve progress towards schistosomiasis elimination, there a critical need developing highly sensitive and specific tools to monitor transmission in near-elimination settings. Although antibody detection promising approach, it usually unable discriminate active infections from past ones. Moreover, crude antigens such as soluble egg antigen (SEA) show cross-reactivity with other parasitic...
Despite growing evidence that infants and very young children can be infected with schistosomes, the epidemiological features risk factors are not well described in this age group. We aimed to assess prevalence of S. mansoni infection under two years from a population known high burden school-aged adults thus inform need for interventions potentially vulnerable In cross-sectional study Mbita Sub-county, along east coast Lake Victoria, Western Kenya, we enrolled 361 aged 6–23 months. The was...
From 1 January 2022 to 4 September 2022, a total of 53 996 mpox cases were confirmed globally. Cases are predominantly concentrated in Europe and the Americas, while other regions also continuously observing imported cases. This study aimed estimate potential global risk importation consider hypothetical scenarios travel restrictions by varying passenger volumes (PVs) via airline network. PV data for network, time first case 1680 airports 176 countries (and territories) extracted from...
Nutrition inadequacy during childhood and adolescence can cause suboptimal growth, intergenerational effects on offspring an increased risk of chronic diseases in adulthood. There is little information the prevalence drivers malnutrition children aged 5-19 years, South-East Asian setting, since most existing interventions have to date targeted undernutrition. We assessed national nutritional indicators, their trends, associated factors among years from 11 countries WHO Asia Region (SEA...
Somatic mutations in BRAF, especially BRAFV600E, are frequently identified papillary thyroid cancer (PTC) tumors. It has been established that expression levels of numbers genes characteristically altered PTC, however, the link between BRAF mutation and gene patterns still elusive. In present study, we analyzed relative wild type BRAFV600E mRNA by using quantitative PCR (qPCR) cDNAPCR- RFLP 19 PTC specimens adjacent normal tissues. was detected 17 out specimens, were valuable among...
Background: More than 80% of all thyroid cancers, the most common endocrine malignancy, are papillary cancer (PTC). It is well established that CITED1 (Cbp/p300 Interacting Transactivators with glutamic acid [E] and aspartic [D]-rich C-terminal domain) mRNA characteristically overexpressed in PTC. Our previous study suggested a positive association BRAF mutation overexpression. However, mechanism expression PTC remains to be elucidated. In present study, we analyzed whether aberrant...
This study explored the factors associated with healthcare avoidance behavior for menstrual disorders and menopausal symptoms among women in Japan. Using data from a nationally representative cross-sectional online survey conducted September 2022, responses 4,950 aged 25-59 were analyzed. applied binomial logistic regression models specifically to participants who reported having ever felt need seek assistance due health issues related menstruation menopause. We computed adjusted odds ratios...
While there is no doubt that total thyroidectomy necessary for medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2A (MEN2A) patients, still controversy regarding the management of parathyroid glands. Although most, but not all, surgeons leave normal-appearing glands situ during surgery MEN2A, we have employed parathyroidectomy with autotransplantation. Between 1994 and 2006, 12 MEN2A patients underwent therapeutic or completion lymph nodes dissection at least central...
Intestinal parasitic infections pose a significant global public health issue, particularly among pregnant women, who are generally more susceptible due to their elevated need for iron and nutrients. Deworming stands as secure efficacious intervention. The World Health Organization (WHO) set target the national deworming coverage rate women at 75% by 2030. Nonetheless, existing body of evidence on in low- middle-income countries (LMICs) remains limited.
患者は62歳男性.食欲不振,腹痛のため当院消化器科を受診した.腹部CT検査にて膵臓と肝臓に腫瘤を認め入院した.入院時, WBC 14,760/mm3, CA19-973U/mlであった.発熱が続いたため肝膿瘍を疑い穿刺ドレナージを行ったが細菌,腫瘍細胞などは認めなかった.血清G-CSFが160pg/mlと高値であったため, G-CSF産生膵癌およびその肝転移と診断し手術を施行した.多発の肝転移を認めたため腫瘍の生検のみを行った.病理検査にて膵臓原発の腺扁平上皮癌と診断した.抗G-CSF抗体による免疫組織染色では主に扁平上皮癌部分が陽性を示した.術後塩酸ゲムシタビンの全身投与, 5Fuの肝動注を行ったが,診断6カ月後に死亡した.
症例は60歳,男性で検診の腹部超音波検査で多発性脾腫瘤を指摘され,当院紹介された.単純CT上軽度脾腫を認めたが腫瘍は不明であった.造影CTでは造影効果のない低吸収性腫瘤が多発していた. MRI上はT2強調画像では低信号を示していた. FDG-PET検査では脾臓のみに集積を認めた.以上より悪性リンパ腫を第一に考え,腹腔鏡補助下脾臓摘出術を施行した.病理組織検査上脾サルコイドーシス症と診断した. 5カ月後皮膚に再発をきたしたが,外用ステロイド治療で軽快している.
Abstract Background Community and individual participation are crucial for the success of schistosomiasis control. The World Health Organization (WHO) has highlighted importance enhanced sanitation, health education, mass treatment in fight against schistosomiasis. These approaches rely on knowledge practices community to be successful; however, where is low inappropriate, it hinders intervention efforts. Hence, essential identify barriers misconceptions related awareness schistosomiasis,...
Maternity and neonatal services always have to operate 24 hours a day 7 days week, require well preparedness guarantee safe deliveries for both mothers babies. However, the evidence of holiday effect from large-scale data is still insufficient obstetrics perspective. We analyzed over 21 million births in Japan January 1, 1979, December 31, 2018. revealed that number lower on holidays, especially among high-risk such as low birthweight preterm births. The frequency birth has been increasing...
Community and individual participation are crucial for the success of schistosomiasis control. The World Health Organization (WHO) has highlighted importance enhanced sanitation, health education, Mass Drug Administration (MDA) in fight against schistosomiasis. These approaches rely on knowledge practices community to be successful; however, where is low inappropriate, it hinders intervention efforts. Hence, essential identify barriers misconceptions related awareness schistosomiasis,...
<title>Abstract</title> <bold>Background</bold>: A cut-off weight of 2500 g in infants, which is commonly referred as low birth was established an indicator perinatal prognosis several decades ago. However, medicine developed dramatically since then and theoutcomes are discussed using other factors including fetal growth nowadays. This study conducted to assess the present situation with recent assessment scales reconsider indicators used for outcome. <bold>Methods</bold>: a retrospective...
症例は68歳の男性で黄疸のため入院した.腹部超音波検査にて膵頭部の腫瘤および尾側膵管の拡張を指摘された.精査の結果,通常の膵管癌とは異なる膵頭部癌の診断で膵頭十二指腸切除術を施行した.切除標本上膵頭部に7.0cmの充実性の結節型腫瘍を認めた.術後病理組織検査にて膵腺扁平上皮癌と診断した.免疫染色で腺癌部分だけでなく中～低分化の扁平上皮癌の部分もCEA, CA19-9, CA15-3で陽性に染まり,扁平上皮癌成分は腺癌の性質を有すると考えられた.発生学的機序として腺癌の直接扁平上皮化が考えられた.
われわれは総胆管と左肝管の間に副交通胆管枝が存在するという非常に稀な肝外胆管形態異常に,尾状葉の肝内結石症を合併した1例を経験した.症例は66歳の女性.平成14年3月3日,腹痛,発熱のため,当院を受診し入院した.腹部超音波検査, CT検査では左側尾状葉内に多数の肝内結石を認めた. MRCP,内視鏡的逆行性胆管膵管造影検査(ERCP)にて総胆管左壁への胆管の合流を認めた.左尾状葉胆管枝の総胆管への異所性合流に肝内結石症が合併したと診断し4月1日手術を施行した.術中胆道造影にて総胆管と左肝管の間に交通する副胆管枝を確認した.左側尾状葉を含む肝左葉切除術を施行した.左尾状葉胆管が副交通胆管枝に合流していることが切除標本で確認された.尾状葉胆管内にはビ系結石が多数充満していた.患者の術後経過は良好であった.術中の胆道造影が胆管走行異常の把握に最も有用であった.
症例は74歳の女性で, 平成13年11月検診で便潜血陽性を指摘された. 前医で下部消化管内視鏡検査を行い, 回盲部に粘膜下腫瘍を認めたが, 生検で悪性像を認めなかったため経過観察とされた. 平成14年5月下部内視鏡検査の生検でmucosa-associated lymphoid tissue (以下, MALTと略記) リンパ腫と診断され, 治療目的に当院紹介された. 採血上Hb 9.5g/dlと軽度低下を認めた. CT上回盲部に壁肥厚を認めた. 骨髄穿刺では異常を認めなかった. 以上より, 回盲部に限局するMALTリンパ腫の診断で平成14年7月回盲部切除術を施行した. 術後病理組織診断は虫垂原発のMALTリンパ腫であった. 腫瘍は漿膜面に露出していたが, リンパ節に転移は認めなかった. 術後経過観察しているが再発の徴候を認めない. まれな虫垂原発MALTリンパ腫の1例を経験したので文献的考察を加えて報告する.
Abstract Background As of 4 September 2020, a total 53,996 monkeypox cases were confirmed globally. Currently, most are concentrated in Europe and the Americas, while many countries outside these regions also continuously observing imported cases. We aimed to estimate potential global risk importation consider hypothetical scenarios travel restrictions by varying passenger volumes via airline network. Method Passenger volume data for network, time first case 1680 airports 176 (and...
症例は75歳の男性で上腹部痛のため入院した.精査にて総胆管結石症の診断であったが,この時のCT検査で後腹膜腔に8.0cm大の多房性腫瘤を指摘された. MRI上腫瘍はT1強調画像で等～高信号を示し, T2強調画像では高信号を示した.また,血清CA19-9の上昇を認めた.後腹膜腫瘍,副腎腫瘍,膵由来の悪性腫瘍を考え,手術を施行した.切除標本では,膵体部より背側に突出する柔らかい多房性腫瘤を認め,術後病理組織検査上嚢胞内壁は皮脂腺を含む重層扁平上皮で覆われ,リンパ組織の形成を多数認めた.さらに免疫染色を施行したところ重層扁平上皮部はCA19-9で陽性に染まり,膵リンパ上皮嚢胞と診断した.術後は経過良好で,血清CA19-9値は正常化した.
症例は49歳の女性で便秘を主訴に入院した.注腸検査でRs～Ra部の直腸に全周性の狭窄を認めた.下部消化管内視鏡検査で病変部はほとんど拡張せず,その粘膜面は浮腫状で軽度発赤を認めた.生検検査はGroup Iであった.悪性腫瘍を疑ってハルトマン手術,子宮,両側付属器合併切除術を施行した.術後病理組織検査で骨盤内放線菌症と診断され,半年間ペニシリンGを投与した.
症例は57歳,男性.糖尿病,アルコール性慢性膵炎のために通院.発熱,嘔吐のため,平成13年7月18日入院した.腹部超音波検査にて肝外側区域に内部不均一な5cm大の充実性腫瘤を認めた.単純CTで肝腫瘤は境界不鮮明な低吸収域を示した.造影CTでは早期相で濃染され晩期相で低吸収域として描出された.また膵頭部は腫瘤を形成していた.上部消化管造影にて十二指腸下行脚に不整な狭窄を認めた. MRCPにて膵内胆管の狭窄を認めた.炎症性肝腫瘤を疑い肝生検を施行し,慢性肝膿瘍の診断を得た後,膵頭十二指腸切除術,肝外側区域切除術を施行した.切除標本の病理検査にて肝腫瘤内に放線菌の菌塊を認め,原発性肝放線菌症と診断した.