A5102924660- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Glycosylation and Glycoproteins Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Nutrition and Health in Aging
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
Nagoya University
2016-2025
The Japanese Society of Gastroenterological Surgery
2021-2024
Niigata University of Health and Welfare
2024
Nagoya University Hospital
2016-2022
Osaka University
2016-2022
Okayama University of Science
2021
University of Tsukuba
2011-2019
Komaki City Hospital
2019
Aichi Medical University Hospital
2017
Aichi University
2016
Abstract Background We aimed to present the 2019 annual report of gastroenterological section National Clinical Database (NCD). Methods reviewed 609,589 cases recorded in and 5,029,764 registered from 2011 for 115 selected surgical procedures. Results The main features surgery Japan were similar those described 2018 report, namely, that 1) operative numbers gradually increased all procedures, except gastrectomy hepatectomy, which decreased these years; 2) eight major surgeries, age...
The National Clinical Database (NCD) of Japan is a nationwide data entry system for surgery, and it marked its 10th anniversary in 2020. aim was to present the 2020 annual report gastroenterological surgery NCD.
Evidence indicates that impaired immunocompetence and nutritional status adversely affect short-term long-term outcomes of patients with cancer. We aimed to evaluate the clinical significance preoperative according Onodera's prognostic nutrition index (PNI) among who underwent curative gastrectomy for gastric cancer (GC). This study included 260 stage II/III GC R0 resection. The predictive values postoperative outcome (morbidity prognosis) were evaluated. PNI was calculated as follows: 10 ×...
A variety of systemic inflammation-based prognostic scores have been explored; however, there has no study to clarify which score could best reflect survival in resected pancreatic cancer patients. Between 2002 and 2014, 379 consecutive patients who underwent curative resection were enrolled. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil lymphocyte ratio (NLR), platelet (PLR), index (PI), nutritional (PNI) for each patient calculated. Survival was evaluated,...
To develop novel diagnostic and therapeutic targets specific for peritoneal metastasis of gastric cancer (GC).Advanced GC frequently recurs because undetected micrometastases even after curative resection. Peritoneal has been the most frequent recurrent pattern gastrectomy is incurable.We conducted a recurrence pattern-specific transcriptome analysis in an independent cohort 16 patients with stage III who underwent adjuvant S-1 screening candidate molecules GC. Next, another 340 were...
Hepatocellular carcinoma (HCC) is one of the major causes cancer-related death especially among Asian and African populations. It urgent that we identify carcinogenesis-related genes to establish an innovative treatment strategy for this disease.Triple-combination array analysis was performed using pair each HCC noncancerous liver samples from a 68-year-old woman. This consists expression array, single nucleotide polymorphism methylation array. The gene encoding collagen type 1 alpha...
Hepatocellular carcinoma (HCC) is one of the top five causes cancer-related deaths worldwide. Recent developments in treatment HCC remain insufficient to cure unresectable disease or prevent HCC. Consistent efforts are, therefore, needed deepen understanding pathogenesis disease. Genome-wide gene expression profile analyses can now detect various candidate genes that are modified by We have developed a new technique identify tumor suppressor genes, triple-combination array analysis, which...
Abstract Background Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required GC and investigate its potential utility as target development therapeutic antibodies (Abs). Methods Transcriptome bioinformatics analyses human cell lines identified neuronal pentraxin receptor ( NPTXR ) candidate molecule. function was probed by modulating expression in cells assessing effects on intracellular signaling...
To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors.Three-hundred twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy (distal or total gastrectomy) included in analysis. Correlations between 21 parameters that can be determined by routine blood tests clinically relevant (grade II higher according to Clavien-Dindo...
Gastric cancer (GC) is a major global health problem that urgently requires novel molecular biomarkers for patient stratification as well therapeutic targets. Anosmin-1 (ANOS1) gene encodes cell adhesion molecule plays diverse roles in multiple malignancies. We performed expression profiling of GC lines and small interfering RNA (siRNA) experiments to determine the effect ANOS1 on phenotype. evaluated association mRNA protein levels patients' tissue sera with clinicopathological factors...
Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim this study was to identify molecules responsible for mediating peritoneal cancer.Transcriptome and bioinformatics analyses were conducted associated metastasis. therapeutic effects intraperitoneally administered small interfering (si) RNA evaluated using mouse xenograft models. Expression mRNA protein determined tissues from cancer.Synaptotagmin XIII (SYT13) expressed at significantly higher levels...