A5062814101- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Esophageal Cancer Research and Treatment
- Cell Adhesion Molecules Research
- Mechanisms of cancer metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
- Renal cell carcinoma treatment
- Molecular Biology Techniques and Applications
- Glycosylation and Glycoproteins Research
Nagoya University
2005-2025
University of Toyama
2023-2025
Nagoya University Hospital
2025
Johns Hopkins University
2021
Cancer Research Center
2021
Nagoya Central Hospital
2017
Nagoya Memorial Hospital
2015
Saga University
2003
To develop novel diagnostic and therapeutic targets specific for peritoneal metastasis of gastric cancer (GC).Advanced GC frequently recurs because undetected micrometastases even after curative resection. Peritoneal has been the most frequent recurrent pattern gastrectomy is incurable.We conducted a recurrence pattern-specific transcriptome analysis in an independent cohort 16 patients with stage III who underwent adjuvant S-1 screening candidate molecules GC. Next, another 340 were...
Abstract Background Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required GC and investigate its potential utility as target development therapeutic antibodies (Abs). Methods Transcriptome bioinformatics analyses human cell lines identified neuronal pentraxin receptor ( NPTXR ) candidate molecule. function was probed by modulating expression in cells assessing effects on intracellular signaling...
Gastric cancer (GC) is a major global health problem that urgently requires novel molecular biomarkers for patient stratification as well therapeutic targets. Anosmin-1 (ANOS1) gene encodes cell adhesion molecule plays diverse roles in multiple malignancies. We performed expression profiling of GC lines and small interfering RNA (siRNA) experiments to determine the effect ANOS1 on phenotype. evaluated association mRNA protein levels patients' tissue sera with clinicopathological factors...
Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim this study was to identify molecules responsible for mediating peritoneal cancer.Transcriptome and bioinformatics analyses were conducted associated metastasis. therapeutic effects intraperitoneally administered small interfering (si) RNA evaluated using mouse xenograft models. Expression mRNA protein determined tissues from cancer.Synaptotagmin XIII (SYT13) expressed at significantly higher levels...
// Mitsuro Kanda 1,* , Dai Shimizu Haruyoshi Tanaka 1 Masahiro Shibata Naoki Iwata Masamichi Hayashi Daisuke Kobayashi Chie Suguru Yamada Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara and Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School Medicine, Nagoya, Japan * These authors have contributed equally to this work Correspondence to: Kanda, email: Keywords : gastric cancer, hepatic metastasis, MFSD4,...
Identification of novel gastric cancer (GC)-related molecules is necessary to improve management patients with GC in both diagnostic and therapeutic aspects. The aim the present study was determine whether protein arginine methyltransferase 5 (PRMT5) acts as an oncogene progression it serves a marker target. We conducted global expression profiling cell lines RNA interference experiments evaluate effect PRMT5 on phenotype cells. analysed tissues 179 assess association mRNA levels...
Prediction of tumor recurrence after curative resection is critical for determining the prognosis patients with gastric cancer (GC). The initiation and progression GC are associated inappropriate immune responses caused by chronic inflammation mucosa. To identify immunoregulatory molecules involved in progression, cell lines 200 pairs normal tissues from were analyzed gene expression, amplification methylation as well function a differentially expressed gene. transcriptome analysis revealed...
Abstract Introduction The prognosis of pancreatic ductal adenocarcinoma (PDAC) in patients with positive peritoneal washing cytology (CY1) is poor. We aimed to evaluate the results staging laparoscopy (SL) and treatment efficacy CY1 based on a resectability classification. Methods retrospectively reviewed 250 PDAC who underwent SL before initial between 2017 2023 at University Toyama. Results breakdown cases by classification was resectable (R):borderline (BR):unresectable locally advanced...
Abstract Background Postoperative adjuvant chemotherapy using oxaliplatin in addition to 5-FU-based anticancer agents has become the standard treatment for colorectal cancer, however, there is insufficient evidence regarding efficacy and safety of combination therapy elderly patients. In this study, retrospective analysis results from CCOG-1302 study was performed confirm them. Methods The patients CAPOX continuous (8 courses CAPOX) intermittent (2 + 4 capecitabine 2 arms were divided into...
Multimodal treatment is now the primary strategy for managing pancreatic cancer. Blood-based protein markers are sometimes useless evaluating real-time disease condition to determine strategies. This study focused on detecting novel exosomal lipid biomarkers, as exosomes contain several biological mediators. Lipidomic analysis was conducted by liquid chromatography-mass spectrometry (LC-MS) using serum exosome-derived samples from four ductal adenocarcinoma (PDAC) patients and healthy...
The prognosis of patients with gastric cancer (GC) hematogenous metastasis is dismal. Identification biomarkers specific for required to develop personalized treatments that improve patients' outcomes. Global expression profiling GC tissues synchronous hepatic without the peritoneal cavity or distant lymph nodes was conducted using next-generation sequencing and identified G protein-coupled receptor 155 (GPR155) as a candidate biomarker. GPR155 transcription suppressed in cell lines compared...
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal. Novel molecular targets for diagnosis and therapy urgently required. This study evaluated expression functions the protein arginine methyltransferase 5 (PRMT5) in HCC. Using HCC cell lines, levels PRMT5 mRNA were determined using quantitative real-time reverse-transcription polymerase chain reaction, effect a small interfering PRMT5-siRNA on phenotype was evaluated. Further, 144 pairs resected liver tissues to evaluate its...
Abstract Background Gastric cancer (GC) with hepatic metastasis has a poor prognosis. Understanding the molecular mechanisms involved in may contribute to development of sensitive diagnostic biomarkers and novel therapeutic strategies. Methods We performed transcriptome analysis surgically resected specimens from patients advanced GC. One genes identified as specifically associated was selected for detailed analysis. GC cell lines knockout candidate gene were evaluated vitro vivo. Expression...
Esophageal squamous cell carcinoma (ESCC), the most common esophageal cancer in East Asia, is among six cancers with highest fatality rates worldwide. Unfortunately, multidisciplinary treatment strategies have not achieved satisfactory outcomes. Therefore, novel insights into molecular biology of ESCC are required to improve treatment. The gene encoding transmembrane adherens junctions-associated protein-1 (AJAP1) expressed by epithelial cells resides chromosome 1p36, which frequently lost...