A5102921877- Complement system in diseases
- Geophysical Methods and Applications
- Ultrasonics and Acoustic Wave Propagation
- Microwave Imaging and Scattering Analysis
- Ultrasound and Cavitation Phenomena
- Ultrasound and Hyperthermia Applications
- Renal Diseases and Glomerulopathies
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Gastric Cancer Management and Outcomes
- Seismic Waves and Analysis
- Underwater Acoustics Research
- Structural Health Monitoring Techniques
- Maritime Navigation and Safety
- Ophthalmology and Visual Impairment Studies
- Indoor and Outdoor Localization Technologies
- Platelet Disorders and Treatments
- Radar Systems and Signal Processing
- Retinal Diseases and Treatments
- Blood groups and transfusion
- Cancer Cells and Metastasis
- Marine and Coastal Research
- Cancer Research and Treatments
- Concrete Corrosion and Durability
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Osaka Minami Medical Center
2024-2025
Osaka University
2024
NTT (Japan)
2014-2024
Konan Kosei Hospital
2022-2023
University of Pennsylvania
2012-2022
Gunma University
2009-2022
Nagoya University
1969-2021
Kanazawa University
1999-2020
Translational Therapeutics (United States)
2009-2019
Zenyaku Kogyo (Japan)
2019
Abstract Renal ischemia-reperfusion injury (IRI) is a feature of ischemic acute renal failure and it impacts both short- long-term graft survival after kidney transplantation. Complement activation has been implicated in IRI, but its mechanism action uncertain the determinants complement during IRI remain poorly understood. We engineered mice deficient two membrane regulatory proteins, CD55 CD59, used them to investigate role these endogenous inhibitors IRI. CD55-deficient (CD55−/−), not...
Factor H (fH) and properdin both modulate complement; however, fH inhibits activation, promotes activation of the alternative pathway complement. Mutations in associate with several human kidney diseases, but whether inhibiting would be beneficial these diseases is unknown. Here, we found that either genetic or pharmacological blockade properdin, which expected to therapeutic, converted mild C3 GN an fH-mutant mouse a lethal features dense deposit disease. We attributed this phenotypic...
Abstract Background Controlling metastasis is essential for improving the prognosis of patients with gastric cancer (GC). Here, we aimed to identify a molecule required GC and investigate its potential utility as target development therapeutic antibodies (Abs). Methods Transcriptome bioinformatics analyses human cell lines identified neuronal pentraxin receptor ( NPTXR ) candidate molecule. function was probed by modulating expression in cells assessing effects on intracellular signaling...
Varicella-zoster virus (VZV), known for causing chickenpox, establishes latent infections in neural tissues. Reactivation of VZV can lead to herpes zoster (HZ) and various neurological complications. In this report, we present four cases meningitis myelitis following amenamevir treatment HZ dermatitis with positive DNA cerebrospinal fluid (CSF) revealed by polymerase chain reaction (PCR). Three them were considered immunocompromised hosts given the fact that two these patients taking...
A full-polarimetric borehole radar system is presented with combinations of dipole antennas and axial slot applied to subsurface fracture measurement. First, determine a scattering matrix from measurements having different antenna transfer functions between orthogonal polarizations, the authors present an compensation algorithm that achieved by inverse filtering method experimentally determined crosshole measurements. The results single-hole carried out in granite at Kamaishi Mine are shown...
Abstract Complement is implicated in the pathogenesis of ischemia-reperfusion injury (IRI). The activation pathway(s) and effector(s) complement IRI may be organ specific remain to fully characterized. We previously developed a renal model decay-accelerating factor (DAF) CD59 double-knockout (DAF−/−CD59−/−) mice. In this study, we used dissect by which activated evaluate whether C3aR- or C5aR-mediated inflammation membrane attack complex was pathogenic. crossed DAF−/−CD59−/− mice with...
Objective— Inflammation contributes to hypertension-induced cardiac damage and fibrotic remodeling. Complement activation produces anaphylatoxins, which are major inflammatory effectors. Here, we investigated the role of complement anaphylatoxins in angiotensin II (Ang II)–induced Approach Results— We measured human plasma levels hypertensive individuals controls studied a mouse model Ang II–induced hypertension injury. found that 5a (C5a) concentration was more elevated than controls....
Patients with peritoneal metastasis of gastric cancer have dismal prognosis, mainly because inefficient systemic delivery drugs to tumors. We aimed develop an intraperitoneal treatment strategy using amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides (ASOs) targeting synaptotagmin XIII (SYT13) and identify the function SYT13 in cells. screened 71 candidate oligonucleotide sequences according SYT13-knockdown efficacy, vitro activity, off-target effects. evaluated effects...
Complement opsonization is among the biggest challenges facing nanomedicine. Nearly instantly after injection into blood, nanoparticles are opsonized by complement protein C3, leading to clearance phagocytes, fouling of targeting moieties, and release anaphylatoxins. While surface polymers such as poly(ethylene glycol) (PEG) partially decrease opsonization, most still suffer from extensive especially when linked moieties. To ameliorate deleterious effects complement, two mammals' natural...
Abstract To prevent complement-mediated autologous tissue damage, host cells express a number of membrane-bound complement inhibitors. Decay-accelerating factor (DAF, CD55) is GPI-linked membrane regulator that widely expressed in mammalian tissues including the kidney. DAF inhibits C3 convertase both classical and alternative pathways. Although deficiency contributes to human hematological syndrome paroxysmal nocturnal hemoglobinuria, relevance autoimmune damage such as immune...
Heritable and acquired diseases of podocytes can result in focal segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte–specific sheep Abs into BALB/c mice. mice deficient the key complement regulator, decay-accelerating factor (DAF), but not WT or CD59-deficient developed histological ultrastructural features FSGS, marked albuminuria, periglomerular monocytic T cell inflammation, enhanced reactivity to IgG. All these findings, which are characteristic...
Sonoporation, which makes micropores through a cell membrane by bubble cavitation, improves the efficacy in ultrasonic wave drug delivery systems. However, effects of cavitation are affected largely condition, such as density and aggregation, just before irradiation high-intensity wave. Aiming at preparing specific condition method uses frequency modulation pumping was proposed. In this paper, sequence evaluated under different flow velocities densities. The spatial correlation between...
Complement is implicated in asthma pathogenesis, but its mechanism of action this disease remains incompletely understood. In study, we investigated the role properdin (P), a positive alternative pathway complement regulator, allergen-induced airway inflammation. Allergen challenge stimulated P release into airways asthmatic patients, and levels positively correlated with proinflammatory cytokines human bronchoalveolar lavage (BAL). High were also detected BAL OVA-sensitized challenged not...
Abstract Background Gastric cancer (GC) with hepatic metastasis has a poor prognosis. Understanding the molecular mechanisms involved in may contribute to development of sensitive diagnostic biomarkers and novel therapeutic strategies. Methods We performed transcriptome analysis surgically resected specimens from patients advanced GC. One genes identified as specifically associated was selected for detailed analysis. GC cell lines knockout candidate gene were evaluated vitro vivo. Expression...