A5020304167- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Gastrointestinal Tumor Research and Treatment
- Frailty in Older Adults
- Colorectal Cancer Surgical Treatments
- Esophageal and GI Pathology
- Diabetes Treatment and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Retinal Diseases and Treatments
- Genetic factors in colorectal cancer
- Dysphagia Assessment and Management
- Esophageal Cancer Research and Treatment
- Clinical Nutrition and Gastroenterology
- Colorectal and Anal Carcinomas
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Cancer Immunotherapy and Biomarkers
- Body Composition Measurement Techniques
- Gut microbiota and health
Kurume University
2012-2025
Kurume University Medical Center
2020-2025
Kurume University Hospital
2023-2024
Kurume Institute of Technology
2024
Biostats (United States)
2024
Kansai Electric Power (Japan)
2023
Kyoto University
1985-2021
Meijo University
2020
Aichi Medical University
2015-2019
Aichi Medical University Hospital
2015-2019
Abstract Dysregulation of the gut microbiome is associated with several life-threatening conditions and thus might represent a useful target for prevention dementia. However, relationship between microbial population dementia has not yet been fully clarified. We recruited outpatients visiting our memory clinic to participate in this study. Information on patient demographics, risk factors, activities daily living was collected, cognitive function assessed using neuropsychological tests brain...
Low-voltage zones (LVZs) represent fibrotic tissue and are substrates for atrial fibrillation (AF). We hypothesized that LVZ-based substrate modification along with pulmonary vein isolation (PVI) would improve outcomes in persistent AF (PeAF) patients LVZs, whereas PVI alone work without LVZs.Voltage mapping of the left atrium (LA) was performed during sinus rhythm 101 PeAF whom LVZ defined as an area bipolar electrograms <0.5 mV. Thirty-nine had LVZs underwent ablation entire after (LVZabl...
Evidence indicates that impaired immunocompetence and nutritional status adversely affect short-term long-term outcomes of patients with cancer. We aimed to evaluate the clinical significance preoperative according Onodera's prognostic nutrition index (PNI) among who underwent curative gastrectomy for gastric cancer (GC). This study included 260 stage II/III GC R0 resection. The predictive values postoperative outcome (morbidity prognosis) were evaluated. PNI was calculated as follows: 10 ×...
Abstract Recent studies have revealed an association between the dysregulation of gut microbiome and dementia. However, whether this is associated with mild cognitive impairment (MCI), early stage decline, in patients without dementia remains unclear. We performed a cross-sectional analysis to determine MCI. Data, including patient demographics, risk factors, function, brain imaging, were collected. The was assessed through terminal restriction fragment length polymorphism analysis....
The International Union Against Cancer highlighted tumor budding as a tumor-related prognostic factor. assessment criteria for were recently defined by the 2016 Tumor Budding Consensus Conference (ITBCC2016). This study aimed to clarify and predictive values of in randomized controlled trial evaluating superiority adjuvant chemotherapy with oral tegafur-uracil over surgery alone stage II colon cancer (SACURA trial; ClinicalTrials.gov identifier: NCT00392899).
A variety of systemic inflammation-based prognostic scores have been explored; however, there has no study to clarify which score could best reflect survival in resected pancreatic cancer patients. Between 2002 and 2014, 379 consecutive patients who underwent curative resection were enrolled. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil lymphocyte ratio (NLR), platelet (PLR), index (PI), nutritional (PNI) for each patient calculated. Survival was evaluated,...
No pharmacological therapies are approved for non-alcoholic fatty liver disease (NAFLD). Luseogliflozin, a sodium glucose cotransporter 2 inhibitor, has been developed the treatment of adults with type diabetes (T2DM). The aim this prospective, single-arm study is to evaluate efficacy luseogliflozin on hepatic fat content and glycated hemoglobin (HbA1c) in T2DM patients NAFLD.Forty NAFLD were treated 2.5 mg/day 24 weeks. Primary end-points changes HbA1c steatosis evaluated by magnetic...
Abstract Background The characterisation of desmoplastic reaction (DR) has emerged as a new, independent prognostic determinant in colorectal cancer. Herein, we report the validation its value randomised controlled study (SACURA trial). Methods included 991 stage II colon cancer patients. DR was classified by central review Mature, Intermediate or Immature based on presence hyalinised collagen bundles and myxoid stroma at front. All clinical pathological data, including characterisations,...
Background Immune checkpoint inhibitor (ICI) therapy has substantially improved the overall survival (OS) in patients with non-small-cell lung cancer (NSCLC); however, its response rate is still modest. In this study, we developed a machine learning-based platform, namely Cytokine-based ICI Response Index (CIRI), to predict of NSCLC based on peripheral blood cytokine profiles. Methods We enrolled 123 and 99 who received anti-PD-1/PD-L1 monotherapy or combined chemotherapy training validation...
Investigation of dietary therapy for diabetes has focused on meal size and composition; examination the effects sequence postprandial glucose management is limited. The fish or meat before rice excursion, gastric emptying incretin secretions were investigated.
Dependent censoring often arises in biomedical studies when time to tumour progression (e.g., relapse of cancer) is censored by an informative terminal event death). For meta-analysis combining existing studies, a joint survival model between and death has been considered under semicompeting risks, which induces dependence through the study-specific frailty. Our paper here utilizes copulas generalize frailty introducing additional source arising from intra-subject association death. The...
To develop novel diagnostic and therapeutic targets specific for peritoneal metastasis of gastric cancer (GC).Advanced GC frequently recurs because undetected micrometastases even after curative resection. Peritoneal has been the most frequent recurrent pattern gastrectomy is incurable.We conducted a recurrence pattern-specific transcriptome analysis in an independent cohort 16 patients with stage III who underwent adjuvant S-1 screening candidate molecules GC. Next, another 340 were...
Aim Several studies on the efficacy of ezetimibe, a potent inhibitor cholesterol absorption, in treating non‐alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have been published; however, results are inconsistent. We undertook meta‐analysis to evaluate ezetimibe NAFLD NASH. Methods PubMed, Medline, Cochrane Library Full Text Database were searched until June 2016. The main inclusion criteria included original investigating use for treatment Identification published work data...
To investigate the diurnal variations of ocular blood flow in healthy eyes using laser speckle flowgraphy (LSFG), and to determine relationship between other parameters.This prospective cross-sectional study was conducted at Nagoya University Hospital. We studied 13 volunteers whose mean age 33.5 ± 7.6 years. The blur rate (MBR), expressing relative flow, on optic nerve head (ONH) choroidal determined by LSFG (LSFG-NAVI) every 3 hours from 6:00 24:00 hours. intraocular pressure (IOP),...
Purpose: The purpose of this study was to evaluate foveal regeneration and the association between retinal restoration visual acuity following reattachment surgery for rhegmatogenous detachment (RRD). Methods: Twenty-nine eyes 29 patients with successfully reattached macula-off RRD were retrospectively analyzed. We used spectral-domain optical coherence tomography image macular regions measure thickness Snellen chart (VA) best-corrected VA (BCVA) at 1, 2, 3, 6, 9, 12 months after vitrectomy....
Abstract Dysregulation of the gut microbiome is associated with dementia. However, relationship between microbiome-associated metabolites and dementia has yet to be identified. Outpatients visiting a memory clinic in Japan enrolled this cross-sectional study; 107 subjects were eligible for study, 25 which had We collected demographics, activities daily living, risk factors, cognitive function, brain imaging data. The was assessed using terminal restriction fragment length polymorphism...
Abstract Background Intraperitoneal chemotherapy using paclitaxel is considered an experimental approach for treating peritoneal carcinomatosis. This study aimed to determine the recommended dose, and evaluate clinical efficacy safety, of combination intravenous gemcitabine, nab-paclitaxel intraperitoneal in patients with pancreatic cancer metastasis. Methods The frequencies dose-limiting toxicities were evaluated, dose was determined phase I. primary endpoint II analysis overall survival...
FLAURA, the prospective trial of osimertinib as a first-line therapy compared with first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), did not show superior survival benefit for in either subgroup Asians or L858R mutation. In addition, superiority second-generation EGFR-TKI is thus far unclear.We reviewed clinical data all consecutive patients who were treated afatinib between May 2016 and October 2019 from 15 institutions Japan. We defined groups based...
A comparison between atezolizumab plus bevacizumab (ATEZO/BEVA) and lenvatinib (LEN) for the treatment of hepatocellular carcinoma (HCC) remains unclear.This study aimed to compare therapeutic effects safety ATEZO/BEVA LEN as first-line therapies HCC.This was a retrospective analysis 810 patients with HCC who underwent (n = 186) or 624) systemic therapy March 2018 2022 at 14 facilities. After propensity score matching, 304 (ATEZO/BEVA group: n 152; 152) were analyzed.After although there no...