A5023223623- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Abdominal Trauma and Injuries
- Biliary and Gastrointestinal Fistulas
- Diagnosis and treatment of tuberculosis
- Infectious Disease Case Reports and Treatments
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diverticular Disease and Complications
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Nutritional Studies and Diet
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Connective Tissue Growth Factor Research
- Amoebic Infections and Treatments
- Cancer Mechanisms and Therapy
- Neuroendocrine Tumor Research Advances
University of the Ryukyus
2015-2025
Urasoe General Hospital
2024
University of the Ryukyus University Hospital
2013-2023
Aichi Medical University
2023
Kagawa University
2023
Ogaki Municipal Hospital
2023
Liechtenstein Institute
2023
Fukuoka Tokushukai Hospital
2021
Saga University
2021
Nagasaki University
2021
Hepatitis B virus (HBV) of a novel genotype (J) was recovered from an 88-year-old Japanese patient with hepatocellular carcinoma who had history residing in Borneo during the World War II. It divergent eight human (A to H) and four ape (chimpanzee, gorilla, gibbon, orangutan) HBV genotypes, as well recently proposed ninth I, by 9.9 16.5% entire genomic sequence did not have evidence recombination any nine genotypes nonhuman genotypes. Based on comparison nucleotide against 1,440 isolates...
Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative concept to nonalcoholic fatty (NAFLD). We aimed investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study.
Acute hepatitis B virus (HBV) infection has been increasing through promiscuous sexual contacts, and HBV genotype A (HBV/A) is frequent in patients with acute (AHB) Japan. To compare the geographic distribution of genotypes chronic (CHB) Japan between 2005 2006 2000 2001, special attention to changes proportion HBV/A, a cohort study was performed survey CHB at 16 hospitals throughout Furthermore, we investigated clinical characteristics each examined genomic HBV/A isolates by molecular...
The proportion of patients who progress to chronicity following acute hepatitis B (AHB) varies widely worldwide. Moreover, the association between viral persistence after AHB and virus (HBV) genotypes in adults remains unclear. A nationwide multicenter study was conducted throughout Japan evaluate influence clinical virological factors on chronic outcomes with AHB. For comparing those self-limited infection, 212 without human immunodeficiency (HIV) coinfection were observed 38 liver centers...
A comparison between atezolizumab plus bevacizumab (ATEZO/BEVA) and lenvatinib (LEN) for the treatment of hepatocellular carcinoma (HCC) remains unclear.This study aimed to compare therapeutic effects safety ATEZO/BEVA LEN as first-line therapies HCC.This was a retrospective analysis 810 patients with HCC who underwent (n = 186) or 624) systemic therapy March 2018 2022 at 14 facilities. After propensity score matching, 304 (ATEZO/BEVA group: n 152; 152) were analyzed.After although there no...
Abstract We examined the epidemiological trends, including distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data 20,547 patients (1996–2019) were analyzed this prospective study. divided study period into four 6-yearly quarters. etiology was categorized as hepatitis B virus (HBV) infection, HBV + C (HCV) HCV both negative (non-BC). The cases per quarter 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) male....
Abstract Aim The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. aim this study was to determine the recent and clinical characteristics NAFLD in Japan. Methods This initially included 410 061 retrospectively enrolled adults from medical health checkup registry for metabolic syndrome, chronic kidney disease, Japan (MIRACLE‐J; UMIN‐CTR no. UMIN000049419), who were evaluated between 2014 2018 at 13 centers Individuals consuming >20 g alcohol/day or with...
Summary Aims A multi‐stakeholder consensus has proposed MASLD (metabolic dysfunction‐associated steatotic liver disease). We aimed to investigate the pathological findings related mid‐term mortality of patients with biopsy‐proven in Japan. Methods enrolled 1349 MASLD. The observational period was 8010 person years. evaluated independent factors associated by Cox regression analysis. also investigated profiles using data‐mining Results prevalence MASH and stage 3/4 fibrosis observed 65.6%...
ABSTRACT It remains unclear whether alcohol intake and cardiometabolic factors are simultaneously associated with liver fibrosis progression in Japanese obese patients. This study investigated influencing using the Aspartate Aminotransferase/Platelet Ratio Index (APRI), which does not include age. We conducted a cross‐sectional of 26 737 (BMI ≥ 25 kg/m 2 ) adults undergoing health checkups. Steatotic disease (SLD) was diagnosed via ultrasonography. Clinical characteristics were analysed...
We present a case of diverticular colitis the ascending colon preceding onset ulcerative colitis. A 58-year-old man presented with positive faecal occult blood test. Colonoscopy disclosed colon. After year's follow-up, typical developed and improved. Diverticular is newly established disorder chronic segmental mucosal inflammation affected by disease. There increasing recognition such cases may be possible pathogenic relationship between two diseases.
Abstract Background and Aims The prevalence of sexually transmitted acute infections the genotype A hepatitis B virus (HBV) has been increasing in Japan. Genotype HBV is associated with an increased risk progression to chronic infection after (AHB) adults. nationwide survey was conducted evaluate geographic distribution, clinical, virologic characteristics AHB (CHB) Methods Five hundred seventy patients were recruited between 2005 2010, 3682 CHB 2010 2011. genotypes determined for 552 3619...
Abstract Background Previous studies have suggested an association between the use of direct‐acting antiviral agents (DAAs) for treating hepatitis C virus (HCV) infection and resulting decrease in incidence hepatocellular carcinoma (HCC); however, it is unclear whether DAAs prevent recurrence HCC after curative treatment HCC. This study aimed to prospectively investigate its predictors Methods A total 3012 patients with chronic HCV infection, or without cirrhosis, who were treated enrolled...
The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. main outcomes were: death or orthotopic transplantation (OLT), liver-related death, events (hepatocellular carcinoma [HCC], decompensated cirrhosis, gastroesophageal varices/bleeding). 1383 Japanese biopsy-confirmed NAFLD were analyzed. They divided...
The present study was designed to examine the distribution of hepatitis B virus (HBV) genotypes among patients at various stages chronic liver disease type in Okinawa Prefecture, Japan, where prevalence surface antigen is highest Japan despite lowest mortality rate from primary cancer. Serum samples 227 HBV carriers were determined for genotype by polymerase chain reaction (PCR)-restriction fragment length polymorphism. Five sera negative DNA nested PCR and excluded analysis. Genotype...
Abstract The factors contributing to the prognosis of hepatitis B virus (HBV)‐ related chronic liver disease were assessed prospectively in 72 patients with confirmed clinically and pathologically. A comparative study was undertaken between infected genotype those C. During follow‐up period, 13 (81.3%) 16 who initially e antigen (HBeAg) positive became HBeAg negative 14 (51.9%) 27 C negative. had been cleared 8 (61.5%) within first 2 years follow‐up, but only one (7.1%) ( P < 0.05). Four...
A case-control study was undertaken to describe the prevalence of Strongyloides stercoralis infection among patients with autoimmune liver diseases, such as primary biliary cirrhosis (PBC), hepatitis (AIH), and sclerosing cholangitis (PSC). This covered 4,117 who were admitted hospitals in Okinawa, Japan, between 1988 2006. During this period, 538 had following chronic diseases: PBC, AIH, PSC, viral group, alcoholic disease. The other 3,579 hospitalized underwent parasitologic tests served...
Impacts of platelet counts at the time liver biopsy on hepatocellular carcinoma (HCC) development in patients with nonalcoholic fatty disease (NAFLD) remain unknown. The aim this study was to investigate prognostic value biopsy-confirmed NAFLD using data from a multicenter study.One thousand three hundred ninety-eight were included subanalysis CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) Asia study. specimens pathologically diagnosed, and histologically scored NASH Clinical...
Abstract To clarify the correlation between hepatitis B virus (HBV) DNA levels and serum alanine aminotransferase (ALT) in patients with established chronic delta (HDV) infection, sensitive HBV quantitative assays were used for study. Thirty‐four consecutive liver disease who positive both surface antigen (HBsAg) antibody to HDV (anti‐HDV), including 19 hepatitis, 8 cirrhosis 7 hepatocellular carcinoma. All negative Be (HBeAg) HBeAg. was detected 25 (73.5%) of 34 using real‐time detection...
AIM: This study aimed to determine whether metabolic syndrome is directly or indirectly, through fatty liver, associated with elevated gamma-glutamyl transpeptidase (GGT) levels in Japanese women. METHODS:From 4 366 women who received their annual health check-up, 211 were selected for analysis.All negative both hepatitis B surface antigen and antibody C virus.Clinical biochemical variables examined by using univariate multivariate analysis. RESULTS:A raised GGT level (>68 IU/L) was seen 258...
Background:The incidence of hepatocellular carcinoma (HCC) in Japan has still been increasing. The aim the present study was to analyze epidemiological trend HCC western area Japan, Kyushu.Material/Methods:A total 10,010 patients with diagnosed between 1996 and 2008 Liver Cancer group Kyushu (LCSK), were recruited for this study. Cohorts categorized into five year intervals. etiology four groups as follows; B: HBsAg positive, HCV-RNA negative, C: B+C: both nonBC: negative.Results:B 14.8%...