A5063481487- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Hepatitis Viruses Studies and Epidemiology
- Gastric Cancer Management and Outcomes
- Viral gastroenteritis research and epidemiology
- Pelvic and Acetabular Injuries
- Gallbladder and Bile Duct Disorders
- HIV/AIDS drug development and treatment
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Monoclonal and Polyclonal Antibodies Research
- Abdominal Surgery and Complications
- Liver Diseases and Immunity
- Diverticular Disease and Complications
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Intestinal and Peritoneal Adhesions
- Genetic factors in colorectal cancer
- Viral Infections and Immunology Research
- Eosinophilic Esophagitis
- Abdominal vascular conditions and treatments
South Kazakhstan Medical Academy
2023
Peoples' Friendship University of Russia
2016-2021
Russian New University
2019-2021
Russian Academy of Sciences
1998-2017
Central Clinical Hospital
2017
Johns Hopkins Medicine
2014
Johns Hopkins University
2011-2014
Nagoya City University
2004-2013
Bristol-Myers Squibb (Germany)
2013
Novartis (Switzerland)
2013
Hepatitis B virus (HBV) of a novel genotype (J) was recovered from an 88-year-old Japanese patient with hepatocellular carcinoma who had history residing in Borneo during the World War II. It divergent eight human (A to H) and four ape (chimpanzee, gorilla, gibbon, orangutan) HBV genotypes, as well recently proposed ninth I, by 9.9 16.5% entire genomic sequence did not have evidence recombination any nine genotypes nonhuman genotypes. Based on comparison nucleotide against 1,440 isolates...
Hepatitis B virus (HBV) is one of the most widely distributed viruses that infect humankind. Distinct clinical and virological characteristics HBV‐infection have been reported in different geographical parts world are increasingly associated with genetic diversity infecting virus. HBV classified into genotypes subgenotypes ethnicity geography. The its various aspects has subject extensive investigations during last few decades. Since molecular epidemiology research tools become available,...
Blood samples (n=544) from two different populations (Pygmies and Bantus) in Cameroon, West Africa, were analysed. Serological tests indicated that the anti-hepatitis C virus (HCV) prevalence Bantus (20.3 %) was higher than Pygmies (2.3 %, P<0.0001), whereas distribution of hepatitis B (HBV) serological markers equally high both populations: total, 9.4, 17.3 86.8 % for HBsAg, anti-HBs anti-HBc, respectively. HBV genotype A (HBV/A) HBV/E predominant (43.5 each) populations, HBV/D found a...
Hepatitis B virus genotype (HBV/B) has been classified into 5 subgenotypes. Except for Bj/B1 in Japan, the subgenotypes (Ba/B2-B5) have undergone recombination with HBV/C core promoter/precore/core genomic region. Phylogenetic analyses of complete sequences show that Arctic strains belong to a novel subgenotype (HBV/B6) without recombination, analogous what is seen Bj/B1. Comparison 50 HBV/B6 carriers from versus Bj and Ba age- sex-matched Asia revealed clinical characteristics were similar...
Abstract Hepatitis B virus (HBV) has been classified into eight genotypes, and several subgenotypes, distinctly distributed geographically. The genotypes A D were previously reported to be predominant in India. Recent studies indicated evidence of circulation genotype C Eastern part With the aim confirm phylogenetic relation molecular genetic characteristics HBV circulating Kolkata, most populous city India, 11 strains isolated complete genome sequences analyzed. Phylogenetic analysis...
Hepatitis B virus (HBV) subgenotypes Ba, C1 (Cs), and C2 (Ce) are the most prevalent HBV variants in China. To investigate virological characteristics of these their clinical implications, we enrolled a cohort 211 patients Guangdong Province China, including 132 with chronic hepatitis infection (CH), 32 liver cirrhosis (LC), 47 hepatocellular carcinoma (HCC) according to examination, function test, ultrasonograph results. Overall, Ba was found 51.2% (108/211), 33.6% (71/211), 15.2% (32/211)...
Abstract Mexico is considered to be a low endemic country for HBV infection. However, high anti‐HBc against hepatitis B surface antigen (HBsAg) seroprevalence the reported characteristic of native Mexicans. diagnosis and genotype distribution was examined in populations (Nahuas Huichol, n = 306), compared non‐native population (Mestizos, 17). Overall, 6% natives were positive HBsAg 33% had detectable anti‐HBc. prevalence lower Nahuas Huichols (1.4% vs. 9.4%, P < 0.002). Occult detected...
Cost and clinically significant adverse effects are the major limiting factors of interferon (IFN) use in therapy for chronic hepatitis B virus (HBV) infection. A clinical trial was conducted China to study efficiency relevance low-dose regimen IFN treatment HBV infection reveal predicting sustained combined response.During a randomized, open-label control study, e antigen (HBeAg)-positive patients with (n=230) were assigned receive pegylated IFN- alpha -2b (1.0 micro g/kg) (n=115) or (3...
Abstract Studies conducted in different populations worldwide revealed an association between HCV genotype 1 and the development of hepatocellular carcinoma (HCC) than infection with other genotypes. There are reports which reveal 3a (HCV‐3a) hepatic steatosis fibrosis but its relation HCC has not been investigated. In Pakistan, where incidence is increasing, 189 patients chronic liver disease including 82 were enrolled. genotypes determined by phylogeny NS5B region epidemic history HCV‐3a...
Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white African-American populations. This study investigated whether the SNP (rs12979860) is HCV, principally genotype 4, 162 Egyptians (80 clearance). The protective allele was more common those (76.3% vs 57.9%; P = .0006). Individuals were 3.4 (95% confidence interval, 1.8-6.5) times likely to have C/C genotype. Thus, plays a role HCV 4 North Africa.
Recently hepatitis B virus genotype C (HBV/C) has been classified into geographically typical two subtypes (subgenotypes); HBV/C1 in Southeast Asia (Cs) and HBV/C2 East (Ce). Our aim is to develop a rapid subtyping assay examine the virological features of these subtypes. Based on 171 HBV/C strains retrieved from database, 17 single nucleotides polymorphisms (SNPs) were found between Taking advantage five SNPs non-overlapping polymerase region, restriction fragment length polymporphism...
To investigate the association between viral infection pattern and hepatocellular carcinoma (HCC), 292 chronic hepatitis patients, including 108 with developed HCC were screened using serological molecular genetics methods. Viral etiology was established in 267 (91.4%), anti-HCV detected 198 (67.8%), HBsAg 124 (42.5%) 93 (74.4%) cases HDV co-infection. HCV mono-infection predominated both, "non-HCC" "HCC" groups (54% 39%, respectively) higher frequency first group (P = 0.011), whereas HBV...
Aim: A series of recent studies have indicated the presence natural intergenotypic recombinant hepatitis C virus (HCV) strains in distinct parts world. The majority current genotyping methods are based on analysis either 5′UTR, structural (Core/E1/E2) or non‐structural (NS5B) genomic regions virus. Methods: In present study, both and regions, we determined genotype 55 anti‐HCV‐positive intravenous drug users (IDUs) Uzbekistan. Results: HCV‐3a (67.3%) was most prevalent this cohort, followed...
Hepatitis C virus (HCV) genotype is an important determinant of virological response to antiviral therapies. Currently, there are no data available on the molecular epidemiology and interferon susceptibility natural intergenotypic recombinant RF1_2k/1b (RF1) strain.Genotyping RF1-PCR screening were performed samples from 604 HCV RNA-positive individuals 7 countries. uPA/SCID mice carrying human hepatocytes (chimeric mice) infected with strain, strain ribavirin was compared susceptibilities 2...
Abstract The virological characteristics of hepatitis B virus (HBV) implicated in the reactivation occult patients who have received hematopoietic stem‐cell transplantation or chemotherapy for hematological malignancy are not well defined. Twenty‐eight HBsAg‐negative and 138 treated malignant lymphoma with including rituximab were enrolled. Three 28 (10.7%) one (0.72%) developed de novo HBV hepatitis. Anti‐HBc was detected four anti‐HBs two patients. Genotype Bj C they all possessed...
Abstract Egypt is one of the countries with very high rates hepatitis C virus (HCV) related morbidity and mortality. However, little known about geographical clinical differences in genetic variability HCV Egypt. Using direct sequencing phylogenetic analysis partial core/E1 NS5B regions genome, genotype/subtype was determined 129 HCV‐infected patients residing three governates south Egypt: Assuit, Sohag, Qena. According to stage infection, were categorized into four groups: asymptomatic...
Abstract The implication of genotypes is recognized increasingly in the clinical course hepatitis B virus (HBV) and response to anti‐viral drugs C (HCV). Genotypic prevalence both etiological agents varies geographically no data are available for Tajikistan. To investigate epidemiology significance HBV HCV chronic (group 1) liver cirrhosis/hepatocellular carcinoma (HCC) 2) patients Tajikistan, 124 with disease 1 = 84 group 2 40) were enrolled. Genotypes HBV, HCV, delta (HDV) determined by...
This study investigates the molecular epidemiology of HIV in Uzbekistan - a former Soviet Union (FSU) country located central Asia. A total 18,910,370 subjects were involved an serological examination through population survey conducted 1987-2002. Rapid changes epidemiological dynamics and transmission modes have been observed since 1999: incidence rose from 25 newly HIV-infected per year to more than 100 new cases month within first half 2002, rate intravenous drug use (IVDU)-associated...
Hepatitis B virus (HBV) has been classified into seven genotypes, designated A-G. The HBV genotype a characteristic geographical distribution. Republic of Uzbekistan is located in the heart Asia and considered to be region with high endemicity hepatitis viruses. However, present distribution infection this unknown. aim study was investigate genotypes elucidate validity two genotyping systems Uzbekistan. Fifty-four patients surface antigen were investigated. determined by methods: one based...