A5088557400- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Vector-borne infectious diseases
- HIV Research and Treatment
- Viral Infections and Immunology Research
- Medicinal Plant Research
- HIV/AIDS drug development and treatment
- Cervical Cancer and HPV Research
- Essential Oils and Antimicrobial Activity
- Computational Drug Discovery Methods
- Child Nutrition and Water Access
- Systemic Lupus Erythematosus Research
- Parvovirus B19 Infection Studies
- Vector-Borne Animal Diseases
- Liver Disease and Transplantation
- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- Parasites and Host Interactions
- Zoonotic diseases and public health
- Biochemical Acid Research Studies
- Biological and pharmacological studies of plants
Ministry of Health of the Republic of Uzbekistan
2007-2025
Institute of Virology of the Slovak Academy of Sciences
2014-2024
Tashkent Pediatric Medical Institute
2000
The prevalence and incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) are significantly increasing globally, but the index non-invasive is limited. Platelet-albumin ratio(PAR) a biomarker inflammation, aim this study was to evaluate relationship between PAR MASLD. This population-based cross-sectional retrospective analyzed data extracted from National Health Nutrition Survey (NHANES) database 2017 2018. Multivariate logistic regression analysis used correlation...
Background Eastern Europe and Central Asia (EECA) is one of the regions where HIV epidemic continues to grow at a concerning rate. Antiretroviral therapy (ART) coverage in EECA countries has significantly increased during last decade, which can lead an increase risk emergence, transmission, spread variants with drug resistance (DR) that cannot be controlled. Because genotyping performed these countries, data about DR are limited or unavailable. Objectives To monitor circulating HIV-1 genetic...
Chronic infection with hepatitis B and C viruses (HBV & HCV) is a major contributor to liver disease liver-related mortality in Uzbekistan. There need demonstrate the feasibility of large-scale simplified testing treatment implement national viral elimination program.Thirteen polyclinics were utilized screen, conduct follow-up biochemical measures treat chronic HBV HCV general adult population. Task shifting motivational interviewing training allowed nurses provide rapid screening...
Aim: A series of recent studies have indicated the presence natural intergenotypic recombinant hepatitis C virus (HCV) strains in distinct parts world. The majority current genotyping methods are based on analysis either 5′UTR, structural (Core/E1/E2) or non‐structural (NS5B) genomic regions virus. Methods: In present study, both and regions, we determined genotype 55 anti‐HCV‐positive intravenous drug users (IDUs) Uzbekistan. Results: HCV‐3a (67.3%) was most prevalent this cohort, followed...
A controlled prospective cohort study was designed to assess the effectiveness of hygiene promotion on risk reinfection by intestinal parasites in children 276 rural Uzbek households over a 1-year period. The included three groups: seasonality (no medicine, no activity), treatment (medicine provided, activity) and provided activity). Participatory Hygiene Sanitation Transformation methodology utilized as key tool activities. Three behaviors were targeted: hand washing with soap, safe feces...
Abstract Background & Aims The hepatitis B virus (HBV) is endemic in Uzbekistan but the medical impact of infection with HBV‐dependent D (HDV) unknown Country. An Hepatology Center was recently established at Institute Virology Tashkent, which has set up a database enlisting patients chronic viral liver disorders from all over Uzbekistan; it provides an observatory on current scenario Methods prevalence HBV monoinfection, C (HCV) and HDV superinfection surface antigen (HBsAg)‐positive...
Schistosomiasis is a parasitic disease that endangers human health and social development. The granulomatous reaction of Schistosoma eggs in the liver main cause hepatosplenomegaly fibrotic lesions. Anti fibrosis therapy crucial for patients with chronic schistosomiasis. Although Praziquantel only clinical drug used, it limited insecticide treatment has long-term large-scale use, which forcing search cost-effective alternatives. Previous research demonstrated plant metabolites extracts have...
Atherosclerosis, a leading cause of global cardiovascular mortality, is characterized by chronic inflammation. Central to this process the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, which significantly influences atherosclerotic progression. Recent research has identified that olfactory 2 (Olfr2) in vascular macrophages instrumental driving atherosclerosis through NLRP3- dependent IL-1 production.
Abstract A national program of universal vaccination for the prevention chronic hepatitis B virus (HBV) infection was launched in Uzbekistan since 1998. To evaluate 6 years' outcome program, 567 children were enrolled study. Among those enrolled, 333 had immunized with adw2 type based Engerix‐B (Glaxo Smith Kline Beechem, Rixensart, Belgium) and 48 adr Hepavax‐Gene (Green Cross Vaccine Corporation, Korea). cohort 186 born before immunization also included When 45 vaccinated compared to...
Previously, from the tannic sumac plant ( Rhus coriaria ), we developed Rutan 25 mg oral drug tablets with antiviral activity against influenza A and B viruses, adenoviruses, paramyxoviruses, herpes virus, cytomegalovirus. Here, our re-purposing study demonstrated that at 25, 50, 100 mg/kg provided a very effective safe treatment for COVID-19 infection, simultaneously inhibiting two vital enzyme systems of SARS-CoV-2 virus: 3C-like proteinase (3CLpro) RNA-dependent RNA polymerase (RdRp)....
In 2016, the World Health Organization (WHO) set hepatitis elimination targets of 90% reduction in incidence and 65% mortality worldwide by 2030 (1). Hepatitis B virus (HBV) C (HCV) infection prevalences are high Uzbekistan, which lacks funding for meeting WHO's targets. absence large financial donor programs eliminating HBV HCV infections, insufficient is an important barrier to achieving those Uzbekistan other low- middle-income countries. A pilot program using a catalytic model, including...
Introduction: The severity and clinical outcome of COVID-19 depend on virus-specific factors the host's inflammatory response. Identifying biomarkers severe is a crucial condition predicts disease severity. Methodology: This study enrolled total 167 patients with COVID-19. These were categorized into three groups based disease: moderate course - 78 individuals, 52 extremely 37 individuals. We analyzed chemokines (IP-10, CXCL9, CCL17) cytokine IL28B levels using enzyme immunoassay (EIA)...
Abstract Large outbreaks and sporadic cases of hepatitis E have been reported in Central Asia. We assessed the genetic relatedness virus (HEV) strains from outbreak Turkmenistan. Specimens acute non‐A, non‐B were tested by reverse transcription (RT)‐polymerase chain reaction (PCR) to identify presence HEV RNA; nucleotide sequences analyzed. RNA was detected 23/156 (15%) 2/23 (9%) cases. The isolates represented 14 unique with distances varying between 0.3% 8.6%, 12 which closely related,...
Aims Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict treatment outcome for patients with HCV. Furthermore, SNPs in newly discovered IFNL4 are shown to have population-specific correlation spontaneous clearance of The aim this study was examine prevalence and clinical significance outlined a population from Central Asia, multi-ethnic region developing economy high HCV infection. Methods One hundred thirty-five chronic...
The CRF02_AG and sub-subtype A6 are currently the predominant HIV-1 variants in Republic of Uzbekistan, but little is known about their time-spatial clustering patterns high-risk populations. We have applied molecular evolution methods network analyses to better understand transmission these subtypes by analyzing 316 pol sequences obtained during surveillance study HIV drug resistance. Network analysis showed that one third infected persons were organized into clusters, including large...
To determine the value of rotavirus vaccines in Central Asia, we conducted surveillance Uzbekistan, country with largest birth cohort region. Uzbekistan is eligible for international funds to introduce new vaccines.We screened stool samples that were collected from children aged <5 years gastroenteritis 2 hospitals during 2005-2006. Using information and other data, estimated national numbers rotavirus-associated events per year.Of 3537 enrolled children, 1046 (30%) had detected specimens....