A5047541649- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Opioid Use Disorder Treatment
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Memory and Neural Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- Pelvic floor disorders treatments
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Stress Responses and Cortisol
- Syphilis Diagnosis and Treatment
- Menopause: Health Impacts and Treatments
- Neuroscience and Neuropharmacology Research
- Mycobacterium research and diagnosis
- Ureteral procedures and complications
- Vaccine Coverage and Hesitancy
- Viral Infections and Immunology Research
- Williams Syndrome Research
- Oral health in cancer treatment
- COVID-19 epidemiological studies
University of Maryland, Baltimore
2015-2025
Institute of Human Virology
2024
Guru Teg Bahadur Hospital
2023
University College of Medical Sciences
2023
National Institutes of Health
2008-2021
Center for Disease Analysis
2021
AIDS United
2019-2020
Maharaja Yeshwantrao Hospital
2014-2019
Mahatma Gandhi Memorial Medical College
2012-2018
Engineering Associates (United States)
2018
NMDA receptors (NMDARs) are key mediators of certain forms synaptic plasticity and learning. NMDAR complexes heteromers composed an obligatory GluN1 subunit one or more GluN2 (GluN2A-GluN2D) subunits. Different subunits confer distinct physiological molecular properties to NMDARs, but their contribution learning in the adult brain remains uncertain. Here, we generated mice lacking GluN2B pyramidal neurons cortex CA1 subregion hippocampus. We found that hippocampal principal mutants had...
Objective: Research is increasingly linking autism spectrum disorders and other neurodevelopmental to synaptic abnormalities ("synaptopathies"). PSD-95 (postsynaptic density-95, DLG4) orchestrates protein-protein interactions at excitatory synapses a major functional bridge interconnecting neurexinneuroligin-SHANK pathway implicated in disorders. Method: The authors characterized behavioral, dendritic, molecular phenotypic relevant mice with deletion (Dlg4−/−). data from led the...
Growing evidence supports a major contribution of cortical serotonin (5-hydroxytryptamine, 5-HT) to the modulation cognitive flexibility and inflexibility evident in neuropsychiatric disorders. The precise role 5-HT influence gene variation mediating this process is not fully understood. Using touch screen–based operant system, we assessed reversal pairwise visual discrimination as an assay for flexibility. Effects constitutive genetic or pharmacological inactivation transporter (5-HTT) on...
Abstract Background People who inject drugs have a high prevalence of hepatitis C virus (HCV) and significant disease associated with drug use; however, HCV treatment often occurs in absence interventions to address opioid use disorder use–related harms. The impact concurrent initiation agonist therapy (OAT) on outcomes is unknown. Methods In this prospective, open-label, observational trial at harm reduction organization’s drop-in center Washington, DC, 100 patients chronic infection,...
Abstract The 69th World Health Assembly endorsed the Global Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as public health threat by 2030. This was followed Organization's (WHO) global targets care and management of B virus (HBV) C (HCV) infections. These announcements were important in raising awareness calling action; however, tracking countries’ progress towards these elimination goals has provided insights limitations targets. existing compare...
Chronic infection with hepatitis B and C viruses (HBV & HCV) is a major contributor to liver disease liver-related mortality in Uzbekistan. There need demonstrate the feasibility of large-scale simplified testing treatment implement national viral elimination program.Thirteen polyclinics were utilized screen, conduct follow-up biochemical measures treat chronic HBV HCV general adult population. Task shifting motivational interviewing training allowed nurses provide rapid screening...
Mood and anxiety disorders, rodent phenotypic measures modeling these have a strong genetic component. Various assays are used to study the neurobiological basis of fear-related anxiety-related behaviors, phenotype genetically modified mice, elucidate pharmacological modulation behaviors for medication development. Earlier work, however, suggests that different trait mediated by partly overlapping but ultimately distinct factors. In this study, we assessed novel panel 23 C57BL/6JxDBA/2J...
Abstract Antibiotics are diverse in their utility clinical care. They widely prescribed for antimicrobial effect and used as modulators, although rarely, of non-infectious conditions, to influence immune responses, decrease morbidity improve quality life. This review provides a concise summary different classes antibiotics unique properties that allow them be the treatment conditions.
Abstract Background Infection with hepatitis C virus (HCV) increases the risk of extrahepatic manifestations, including cardiovascular disease (CVD). Cardiac magnetic resonance (CMR) remains gold standard test for non-invasive structural and functional assessment heart can be used to detect CVD. We sought determine CVD in patients HCV prior therapy using CMR.Table 1.Baseline Demographic Features CMR Cohort Methods Individuals chronic infection were prospectively enrolled CHROME study (NCT...
Abstract Background Tanzania’s estimated HCV prevalence is the highest in Africa at 2.7%. Among people with opioid use disorder (OUD) Dar es Salaam, most populous city, positive Ab to be 16.2% 50.2%. With limited treatment available, patient-centered service delivery through collocating other services, task shifting non-specialists, and streamlined testing algorithms are needed lower barriers treatment. The objective of this study was determine effectiveness routine medically assisted...
The misfortunate incident of formation a urogenital fistula remains major challenge for surgical urologists worldwide. Such fistulae may not be life-threatening problem, but surely the women face demoralization, social boycott and even divorce separation. vaginal, recto-vaginal or combination two. World Health Organization (WHO) has estimated that in developing nations, nearly 5 million annually suffer severe morbidity with obstetric being foremost on list. objective our study was to...
Documentation of antibiotic indication provides helpful information for antimicrobial stewardship, but accuracy is not understood. Review 396 orders in a pediatric ICU and adult medicine step-down unit found 90% agreement between provider-selected independent review. Prompts to enter during order entry provide largely accurate information. Infect Control Hosp Epidemiol 2018;39:111–113
Objective: The ANCHOR program offered buprenorphine treatment to people who inject drugs engaged in hepatitis C (HCV) at a Washington, DC harm reduction organization. This analysis describes the model and outcomes of opioid care continuum 1 year. Methods: Primary were initiation retention care, defined by an active prescription given time points. Secondary included interruptions, reasons for noninitiation termination, opiate use, HIV risk behaviors. Buprenorphine use measured urine...
Histoplasmosis is an endemic mycosis with most cases of clinical illness reported in North and Central America. Rarely, patients develop progressive disseminated histoplasmosis extrapulmonary manifestations. These infections are fatal if not appropriately treated. We report a case presenting fever, dyspnea, pancytopenia 51-year-old Caucasian man who had been treated chronic steroids for diagnosis sarcoidosis made 20 years previously. His presentation was initially mistaken but, fortunately,...