A5074235648- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Liver physiology and pathology
- COVID-19 Clinical Research Studies
- Diet, Metabolism, and Disease
- Hepatitis Viruses Studies and Epidemiology
- Systemic Lupus Erythematosus Research
- Amoebic Infections and Treatments
- Ethics and bioethics in healthcare
- COVID-19 and healthcare impacts
- Drug-Induced Hepatotoxicity and Protection
- Long-Term Effects of COVID-19
- Health and Medical Education
- SARS-CoV-2 and COVID-19 Research
- Helicobacter pylori-related gastroenterology studies
- Pancreatitis Pathology and Treatment
- Galectins and Cancer Biology
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Parasitic Infections and Diagnostics
- Pharmacogenetics and Drug Metabolism
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2015-2024
Universidad Nacional Autónoma de México
2010-2023
Tecnológico de Monterrey
2022
Hospital General de México
2005-2020
Instituto Nacional de Salud Pública
2018
Weatherford College
2018
Yahoo (United Kingdom)
2014
Centre Hospitalier Laennec
2013
Newcastle University
2013
American Association for the Study of Liver Diseases
2010
Background As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico become third country with highest death rate worldwide. Data regarding in-hospital mortality and its risk factors, as well impact of hospital overcrowding America not been thoroughly explored. Methods findings In this prospective cohort study, we enrolled consecutive adult patients hospitalized confirmed COVID-19 pneumonia at a SARS-CoV-2 referral center City from...
There is preliminary evidence that colchicine, an inhibitor of collagen synthesis, may be beneficial in the treatment cirrhosis liver. To evaluate use colchicine (1 mg per day, five days week) hepatic cirrhosis, we performed a randomized, double-blind, placebo-controlled trial which 100 patients were followed for up to 14 years. forty-five had alcoholic 41 posthepatitic and remaining with various other causes. Histologic studies available 92 percent patients. Seventy-three Child–Turcotte...
Morbidity and mortality attributable to chronic hepatitis C virus (HCV) infection are increasing in many countries as the infected population ages. Models were developed for 15 quantify characterize viremic population, well estimate number of new infections HCV related deaths from 2013 2030. Expert consensus was used determine current treatment levels outcomes each country. In most countries, prevalence has already peaked. every country studied, begins decline before 2030, when held...
The free proline, glutamic acid, and total collagen contents of the livers cirrhotic noncirrhotic patients were determined. amounts proline in sera also results indicated that certain metabolic changes occurred humans similar to observed previously CCl(4)-induced cirrhosis rat. amount was coordinate with increase collagen, both inversely related acid. average concentration not higher than non patients, suggesting alteration noted above is a local event liver fibrogenesis. These other suggest...
Summary Chronic hepatitis C virus ( HCV ) infection is a leading cause of liver related morbidity and mortality. In many countries, there lack comprehensive epidemiological data that are crucial in implementing disease control measures as new treatment options become available. Published literature, unpublished expert consensus were used to determine key parameters, including prevalence, viremia, genotype the number patients diagnosed treated. this study 15 viremic prevalence ranged from...
Hospital length-of-Stay has been traditionally used as a surrogate to evaluate healthcare efficiency, well hospital resource utilization. Prolonged Length-of-stay (PLOS) is associated with increased mortality and other poor outcomes. Additionally, these patients represent significant economic problem on public health systems their families. We sought describe compare characteristics of Normal Length-of-Stay (NLOS) PLOS identify sociodemographic disease-specific factors in tertiary care...
Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding pandemic.Objective: The objective study to describe clinical features COVID-19 diagnosed in tertiary-care center Mexico City and assess differences according treatment setting (ambulatory vs. hospital) need intensive care (IC).Methods: We conducted prospective cohort, including consecutive
Abstract Severe COVID-19 is associated with a systemic hyperinflammatory response leading to acute respiratory distress syndrome (ARDS), multi-organ failure, and death. Galectin-3 ß-galactoside binding lectin known drive neutrophil infiltration the release of pro-inflammatory cytokines contributing airway inflammation. Thus, we aimed investigate potential galectin-3 as biomarker severe outcomes. We prospectively included 156 patients RT-PCR confirmed COVID-19. A outcome was defined...
Five different target mitochondrial autoantigens recognized by sera from patients with primary biliary cirrhosis (PBC) have been identified as subunits of the following 2-oxo acid dehydrogenase complexes: pyruvate complex (PDC), branched chain (BCOADC), and 2-oxoglutarate (OGDC). Unlike E2 PDC (PDC-E2) BCOADC (BCOADC-E2), OGDC (OGDC-E2) reactivity PBC reactive epitope OGDC-D2 not hitherto studied in detail. In this report, we took advantage a recombinant fusion protein for OGDC-E2 to address...
Abstract Background Early treatment of coronavirus disease 2019 (COVID-19) with remdesivir in high-risk patients, including those immunosuppression different causes, has not been evaluated. The objective this study was to assess the clinical effectiveness early among patients mild moderate COVID-19 at high risk progression. Methods This prospective cohort comparative conducted a tertiary referral center Mexico City. Patients for progression were treated an ambulatory 3-day course remdesivir....
Nonalcoholic fatty liver disease (NAFLD) encompasses: (SS), steatohepatitis (NASH) with or without fibrosis and cirrhosis. Patatine-like phosphatas in domain 3 (PNPLA3; adiponutrin; SNP rs738409 C/G, M148I) shows anabolic catabolic activities on lipid metabolism significant association to content; however, I148M demographics ethnics, as its role NAFLD have not been fully elucidated.
Summary The hepatitis C virus ( HCV ) epidemic was forecasted through 2030 for 15 countries, and the relative impact of two scenarios considered: (i) increased treatment efficacy while holding treated population constant (ii) annual population. Increasing levels diagnosis treatment, in combination with improved efficacy, were critical achieving substantial reductions disease burden. In most had to increase several fold achieve largest ‐related morbidity mortality. This suggests that capacity...