A5033888353- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Liver Disease and Transplantation
- Antibiotic Resistance in Bacteria
- Organ Transplantation Techniques and Outcomes
- Hematological disorders and diagnostics
- COVID-19 and Mental Health
- Heart Failure Treatment and Management
- COVID-19 Impact on Reproduction
- Neurological disorders and treatments
- Cardiac Structural Anomalies and Repair
- Vaccine Coverage and Hesitancy
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
- Mechanical Circulatory Support Devices
- Global Maternal and Child Health
- Intensive Care Unit Cognitive Disorders
- Transplantation: Methods and Outcomes
- Blood Pressure and Hypertension Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
University of Washington
2020-2025
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2018-2024
Institute for Health Metrics and Evaluation
2024
Seattle University
2022-2023
Duke University
2023
Deleted Institution
2023
Foundation for Physical Medicine and Rehabilitation
2021
Universidad de Sonora
2009
Background As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has remained in Latin America, Mexico become third country with highest death rate worldwide. Data regarding in-hospital mortality and its risk factors, as well impact of hospital overcrowding America not been thoroughly explored. Methods findings In this prospective cohort study, we enrolled consecutive adult patients hospitalized confirmed COVID-19 pneumonia at a SARS-CoV-2 referral center City from...
Antimicrobial resistance (AMR) is an urgent global health challenge and a critical threat to modern care. Quantifying its burden in the WHO Region of Americas has been elusive—despite region’s long history surveillance. This study provides comprehensive estimates AMR assess this growing threat. We estimated deaths disability-adjusted life-years (DALYs) attributable associated with for 23 bacterial pathogens 88 pathogen–drug combinations countries 2019. obtained data from mortality...
Background: Regional information regarding the characteristics of patients with coronavirus disease (COVID)-19 is needed for a better understanding pandemic.Objective: The objective study to describe clinical features COVID-19 diagnosed in tertiary-care center Mexico City and assess differences according treatment setting (ambulatory vs. hospital) need intensive care (IC).Methods: We conducted prospective cohort, including consecutive
Background: Benefit from cardiac resynchronization therapy (CRT) varies by QRS characteristics; individual randomized trials are underpowered to assess benefit for relatively small subgroups. Methods: The authors analyzed patient-level data pivotal CRT (MIRACLE [Multicenter InSync Randomized Clinical Evaluation], MIRACLE-ICD ICD II Evaluation II], REVERSE [Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction], RAFT [Resynchronization-Defibrillation Ambulatory Heart...
The progressive disseminated histoplasmosis (PDH) has been associated with severe disease and high risk of death among people living HIV (PLWHIV). Therefore, the purpose this multicenter, prospective, double-blinded study done in ten Mexican hospitals was to determine diagnostic accuracy detecting Histoplasma capsulatum antigen urine using IMMY ALPHA EIA kit (IAHE), clarus GM Enzyme Immunoassay (cHGEI IMMY) MiraVista Urine Antigen LFA (MVHUALFA); as well Hcp100 1281-1283220SCAR nested PCRs...
Sarcopenia has been related to negative outcomes in different clinical scenarios from critical illness chronic conditions. The aim of this study was verify whether there an association between low skeletal muscle index and in-hospital mortality, intensive care unit admission, invasive mechanical ventilation need hospitalized patients with COVID-19.This a retrospective cohort referral center for COVID-19. We included all consecutive admitted the hospital February 26 May 15, 2020, confirmed...
The COVID-19 pandemic has brought unprecedented changes to medical education. However, no data are available regarding the impact may have on training in Mexico. aim of our study was evaluate and identify school students' perceptions their clinical due Mexico.This a cross-sectional where previous validated online survey translated adapted by education experts applied senior students from March April 2021. 16-item questionnaire distributed combining dichotomous, multiple-choice, 5-point...
Cirrhosis is a public health threat associated with high mortality. Alcoholic Liver Disease (ALD) the leading cause in Latin America and Metabolic Associated Fatty (MAFLD) western countries. In Mexico, ALD chronic Hepatitis C Virus infection (HCV) were most frequent aetiologies during past decades. We aimed to describe trends of cirrhosis middle-income country.We performed retrospective cohort study including patients diagnosed between 2000 2019 from six different tertiary care hospitals...
Throughout the COVID-19 pandemic, thousands of temporary ICUs have been established worldwide. The outcomes and management mechanically ventilated patients in these areas remain unknown.
Abstract Background: The sensitivity of a cancer screening biomarker to detect prevalent preclinical drives benefit. Studies estimate at different points in the development process. We examine how closely these estimates reflect (preclinical sensitivity). Methods: posit that is inversely proportional sojourn time. simulate studies and corresponding Early Detection Research Network’s Phases Biomarker Development. Sensitivity based on clinically diagnosed cases (Phase 2, clinical sensitivity),...
Heart transplantation (HT) remains the gold-standard therapy for end-stage heart failure (HF). Conversely, left ventricular assist device (LVAD) technology made significant strides, reaching 2 year overall survival comparable to HT.1 In old HT allocation system, ~50% of occurred in LVAD patients with lower waitlist mortality, and their 5 post-HT outcomes were equivalent those without LVAD.2 On October 18, 2018, transplant system changed (ASC) into a six tiered classification prioritize most...
The new American College of Cardiology/American Heart Association 2017 Hypertension Guidelines lower the threshold to define hypertension, thus increasing its prevalence. impact on populations and health systems is poorly understood. We included data from 990 subjects aged 20 64 years SALMEX cohort (Salt in Mexico; Mexico City) determined prevalence hypertension requirement for pharmacological treatment according both Joint National Committee Prevention, Detection, Treatment High Blood...
Healthcare systems worldwide were challenged during the COVID-19 pandemic. In Mexico, public hospitals that perform most transplants adapted to provide care for patients. Using a nationwide database, we describe first report of impact and related transplantation healthcare policies in middle-income country by comparing statistics before pandemic (pre-COVID: March 2019-February 2020 vs. COVID era: 2020-February 2021) type institution (public private). The global reduction was higher...
Metabolic-associated fatty liver disease (MAFLD) is a leading cause of chronic disease. Nowadays, the prevalence MAFLD in Mexico unknown with no screening point-of-care tools. We aimed to estimate and develop score for screening.
The true sensitivity of a cancer screening test, defined as the frequency with which test returns positive result if is present, key indicator diagnostic performance. Given challenges directly assessing in prospective program, proxy measures for are frequently reported. We call one such empirical sensitivity, it given by observed ratio screen-detected cancers to sum and interval cancers. In setting canonical three-state Markov model progression from preclinical onset clinical diagnosis, we...
Background and aims COVID-19 vaccination has proved to be effective prevent symptomatic infection severe disease even in immunocompromised patients including liver transplant patients. We aim assess the impact of on mortality development critical our center. Methods A retrospective cohort study LT a reference center between March 2020 February 2022. Demographic data, cirrhosis etiology, time transplantation, immunosuppressive therapies, status were recorded at diagnosis. Primary outcome was...
Thrombotic events are well documented in primary erythrocytosis, but it is uncertain if secondary etiologies increase the risk of thrombosis. This study aimed to determine causes erythrocytosis and identify its impact as a factor for thrombosis.Data were obtained from patients with between 2000 2017 at referral hospital Mexico City. Erythrocytosis was defined according 2016 WHO classification. Time thrombosis, major bleeding, or death compared among groups by etiology using Cox regression...
Early post-liver transplant (LT) acute kidney injury (AKI) has been associated with worse short-term and long-term outcomes, but the incidence risk factors in our population are unknown.We designed a prospective, singlecenter, longitudinal cohort study to determine of AKI during immediate postoperative period LT, identify after LT. Pre-operative intraoperative variables were analyzed if there was any correlation development post-operative AKI.Eighty-six patients included final analysis; from...
Abstract Aims To investigate the association of cardiac resynchronization therapy (CRT) on outcomes among participants with and without a history atrial fibrillation (AF). Methods Individual‐patient‐data from four randomized trials investigating CRT‐Defibrillators (COMPANION, MADIT‐CRT, REVERSE) or CRT‐Pacemakers MIRACLE) were analyzed. Outcomes time to composite heart failure hospitalization all‐cause mortality alone. The CRT for patients AF was assessed using Bayesian‐Weibull survival...