A5015338865- T-cell and Retrovirus Studies
- Lymphoma Diagnosis and Treatment
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Hepatitis B Virus Studies
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Acute Myeloid Leukemia Research
- Vector-Borne Animal Diseases
- CAR-T cell therapy research
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- T-cell and B-cell Immunology
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Animal Disease Management and Epidemiology
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Magnetic Field Sensors Techniques
- Cutaneous lymphoproliferative disorders research
- RNA modifications and cancer
Nagoya University
2008-2025
The University of Tokyo
1995-2025
Kanazawa University
2025
Frontier Aerospace Corporation (United States)
2025
Aichi Medical University
2015-2024
Nagoya Institute of Technology
2024
Pharmaceuticals and Medical Devices Agency
2018
Nagoya City University
2005-2014
Aichi Cancer Center
1993-2014
Kyowa Kirin (Japan)
2010-2014
Adult T-cell leukemia-lymphoma (ATL) is usually resistant to conventional chemotherapies, and there are few other treatment options. Because CC chemokine receptor 4 (CCR4) expressed on tumor cells from most patients with ATL, KW-0761, a humanized anti-CCR4 monoclonal antibody, which markedly enhances antibody-dependent cellular cytotoxicity, was evaluated in the of relapsed ATL.A multicenter phase II study KW-0761 for relapsed, aggressive CCR4-positive ATL conducted evaluate efficacy,...
Our previous phase II trial for treating human T-lymphotropic virus type I-associated adult T-cell leukemia-lymphoma (ATLL) with vincristine, cyclophosphamide, doxorubicin, and prednisone (VCAP), ranimustine, (AMP), vindesine, etoposide, carboplatin, (VECP) showed promising results. To test the superiority of VCAP-AMP-VECP over biweekly (CHOP), we conducted a randomized controlled exclusively ATLL.Previously untreated patients aggressive ATLL were assigned to receive either six courses every...
KW-0761, a defucosylated humanized anti-CC chemokine receptor 4 (CCR4) antibody, exerts strong antibody-dependent cellular cytotoxic effect. This phase I study assessed the safety, pharmacokinetics, recommended II dose and efficacy of KW-0761 in patients with relapsed CCR4-positive adult T-cell leukemia-lymphoma (ATL) or peripheral lymphoma (PTCL).Sixteen received once week for weeks by intravenous infusion. Doses were escalated, starting at 0.01, 0.1, 0.5, finally 1.0 mg/kg 3 +...
CC chemokine receptor 4 (CCR4) is expressed by peripheral T-cell lymphomas (PTCLs) and associated with poor outcomes. Mogamulizumab (KW-0761) a defucosylated humanized anti-CCR4 antibody engineered to exert potent antibody-dependent cellular cytotoxicity. This multicenter phase II study evaluated the efficacy safety of mogamulizumab in patients relapsed PTCL cutaneous lymphoma (CTCL).Mogamulizumab (1.0 mg/kg) was administered intravenously once per week for 8 weeks CCR4-positive or CTCL. The...
Summary This multicentre, randomized, phase II study was conducted to examine whether the addition of mogamulizumab, a humanized anti‐ CC chemokine receptor 4 antibody, mLSG 15, dose‐intensified chemotherapy, further increases efficacy without compromising safety patients with newly diagnosed aggressive adult T‐cell leukaemia‐lymphoma ( ATL ). Patients were assigned 1:1 receive 15 plus mogamulizumab or alone. The primary endpoint complete response rate (% CR ); secondary endpoints included...
Abstract Purpose: FoxP3+ Tregs inhibit immune responses against tumors. KW-0761 is a humanized anti-human CCR4 monoclonal antibody (mAb) that has antibody-dependent cellular cytotoxicity activity. Depletion of CCR4-expressing CD4 by infusion was investigated in solid cancer patients. Experimental Design: We conducted phase Ia clinical trial 7 lung and 3 esophageal Toxicity, efficacy, changes lymphocyte subpopulations, including Tregs, induction were analyzed. Results: The results showed dose...
Human IgG1 antibodies with low fucose contents in their asparagine-linked oligosaccharides have been shown recently to exhibit potent antibody-dependent cellular cytotoxicity (ADCC) vitro. To additionally investigate the efficacy of human enhanced ADCC, we generated defucosylated chimeric anti-CC chemokine receptor 4 (CCR4) antibody KM2760. KM2760 exhibited much higher ADCC using peripheral blood mononuclear cells (PBMCs) as effector compared highly fucosylated, but otherwise identical IgG1,...
The entire nucleotide sequences of 70 hepatitis B virus (HBV) isolates genotype (HBV/B), including 38 newly determined and 32 retrieved from the international DNA database (DDBJ/EMBL/GenBank), were compared phylogenetically. Two subgroups HBV/B identified based on sequence divergence in precore region plus core gene, one with recombination C other without it. analysis over genome by SimPlot program located gene spanning positions 1740 to 1838 2443 2485. Within this genomic area, strains had...
Abstract Hodgkin lymphoma (HL) is characterized by the presence of a small number tumor cells in rich background inflammatory cells, but contribution abundant nontumor to HL pathogenesis poorly understood. We showed that migratory CD4+ induced were hyporesponsive T-cell receptor stimulation and suppressed activation/proliferation effector T an autologous setting. further affected lymph nodes surrounded large lymphocytes expressing both CC chemokine 4 (CCR4) FOXP3. These findings indicate...
A study was conducted to examine the significance of genetic instability and aberrant DNA methylation during hepatocarcinogenesis. Genomic extracted from 196 microdissected specimens noncancerous liver tissue that showed no marked histologic findings or compatible with chronic hepatitis cirrhosis, 80 corresponding hepatocellular carcinoma (HCC) 40 patients. Loss heterozygosity (LOH) microsatellite (MSI) were examined by polymerase chain reaction (PCR) using 39 markers, status on 8 CpG...
Abstract Purpose: Adult T-cell leukemia/lymphoma (ATLL) has a very poor prognosis. We have developed the humanized defucosylated anti–CC chemokine receptor 4 (CCR4) monoclonal antibody KW-0761 as next generation immunotherapeutic agent. The first aim of present study was to evaluate whether antitumor activity would likely be sufficient for therapeutic clinical application against ATLL. second fully elucidate mechanism antibody-dependent cellular cytotoxicity (ADCC) mediated by this antibody....
The outcome of acute hepatitis B virus (HBV) infection is variable, influenced by host and viral factors. From 1982 through 2004, 301 patients with HBV entered a multi-center cross-sectional study in Japan. Patients fulminant (n = 40) were older (44.7 ± 16.3 vs. 36.0 14.3 years, P < .0017), less predominantly male (43% 71%, .0005), positive for e antigen (HBeAg) (23% 60%, .0001), infected subgenotype Ae (0% 13%, .05), more frequently Bj (30% 4%, .0001) than those self-limited 261)....
Cobalt and Co‐Ni alloy were electrodeposited into the micropores of various kinds anodic oxide films on aluminum. Fine granular metals precipitated barrier layer formed columnar structures. Although cobalt or nickel showed remarkable magnetic anisotropies perpendicular to surface, which consisted approximately 50% a strong anisotropy along horizontal direction. Coercive forces ranged from about 500 1100 oe density residual magnetization rose above 1000 gauss. The may have applications in...