A5063044564- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Semiconductor Quantum Structures and Devices
- Semiconductor materials and devices
- Semiconductor Lasers and Optical Devices
- GaN-based semiconductor devices and materials
- Photonic and Optical Devices
- Advancements in Semiconductor Devices and Circuit Design
- Quantum and electron transport phenomena
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Hepatitis Viruses Studies and Epidemiology
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Drug Transport and Resistance Mechanisms
- Thin-Film Transistor Technologies
- Hepatitis C virus research
- Veterinary medicine and infectious diseases
- Viral gastroenteritis research and epidemiology
- Acute Lymphoblastic Leukemia research
- Diabetes Treatment and Management
- Clinical Nutrition and Gastroenterology
- Radio Frequency Integrated Circuit Design
Gifu Municipal Hospital
2014-2024
Keyence (Japan)
2024
Kagawa University
2023
Aichi Medical University
2023
Ogaki Municipal Hospital
2023
Chiba University
1999-2023
J. F. Oberlin University
2021
Tokai University
2014-2020
Kyoto Institute of Technology
1991-2018
Hayashi Eye Hospital
2012-2017
Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs acute inflammatory models. We determined that NETosis is more prevalent aged mice investigated the role PAD4/NETs age-related fibrosis. Reduction was seen hearts lungs PAD4-/- compared with wild-type (WT) mice. An increase left ventricular interstitial collagen...
Metabolic dysfunction-associated steatotic liver disease (MASLD) was recently proposed as an alternative concept to nonalcoholic fatty (NAFLD). We aimed investigate the prognosis of patients with biopsy-confirmed MASLD using data from a multicenter study.
ST Segment Elevation by Class IC Drugs. We evaluated two patients without previous episodes of syncope who showed characteristic ECG changes similar to Brugada syndrome following administration drugs, flecainide and pilsicainide, but not IA drugs. Patient 1 had frequent paroxysmal atrial fibrillation resistant After treatment with flecainide, the a marked elevation in leads V 2 , 3 coved‐type configuration segment lead . A signal‐averaged late potentials that became more prominent after...
The noninvasive tests (NITs) Agile 3+ and 4 effectively identify patients with nonalcoholic fatty liver disease (NAFLD) complicated advanced fibrosis (F3-4) cirrhosis (F4), respectively. Little information is available on associations between scores intra-/extrahepatic events. aim of this study was to determine the predictive performance for events in Asian biopsy-proven NAFLD.We undertook a retrospective multicenter cohort investigate two scores, 4. were obtained by combining clinical...
Summary Aims A multi‐stakeholder consensus has proposed MASLD (metabolic dysfunction‐associated steatotic liver disease). We aimed to investigate the pathological findings related mid‐term mortality of patients with biopsy‐proven in Japan. Methods enrolled 1349 MASLD. The observational period was 8010 person years. evaluated independent factors associated by Cox regression analysis. also investigated profiles using data‐mining Results prevalence MASH and stage 3/4 fibrosis observed 65.6%...
Patients with superficial (mucosal or submucosal) esophageal carcinoma (SEC) have significantly better survival rates than patients advanced carcinoma. Some been reported to test positive for serum p53 antibodies (Abs). Because very few examined, the aim of this study was evaluate clinical significance p53-Abs in squamous cell (SESCC).Thirty-five consecutive SESCC were studied by enzyme-linked immunoabsorbent assay before and after treatment. The clinicopathologic features seropositive...
Radiofrequency ablation (RFA) is a promising, minimally invasive treatment for hepatocellular carcinoma (HCC). However, thermal injury sometimes occurs in the bile duct, potentially leading to critical situation. The aim of present study was investigate whether duct reduced by an intraductal chilled saline perfusion (ICSP) through nasobiliary tube during RFA HCC.The baseline incidence at Gifu Municipal Hospital 3.1% (13 patients) 424 patients with HCC treated percutaneous RFA. In all...
Several studies have reported that insulin resistance raises the risk of primary hepatocellular carcinoma (HCC). We conducted a prospective, case series study to test impact on recurrence after curative radiofrequency ablation (RFA) stage I HCC in HCV-positive patients.From January 2006 December 2007, 226 consecutive patients underwent treatment for at our institutions, including 37 cases. Among them, 33 were HCV-positive, and three, six 24 received surgery, transarterial chemoembolization...
The relationship between baseline serum albumin level and long-term prognosis of patients with nonalcoholic fatty liver disease (NAFLD) remains unknown. This is a sub-analysis the CLIONE (Clinical Outcome Nonalcoholic Fatty Liver Disease) study. main outcomes were: death or orthotopic transplantation (OLT), liver-related death, events (hepatocellular carcinoma [HCC], decompensated cirrhosis, gastroesophageal varices/bleeding). 1383 Japanese biopsy-confirmed NAFLD were analyzed. They divided...
Background/Aim: Peripheral blood inflammatory and nutritional indices are independent prognostic factors for various cancers. However, as society's longevity the demand surgery in elderly increase, it remains unclear whether these valuable patients aged ≥80 years. This study aimed to assess utility of peripheral markers with gastric cancer (GC). Patients Methods: included 103 (aged years) who underwent radical gastrectomy at our hospital between 2008 2020. Preoperative systemic indices,...
Aim Radiofrequency ablation ( RFA ) is a promising alternative to hepatic resection for the treatment of hepatocellular carcinoma HCC located in caudate lobe. We evaluated therapeutic efficacy and safety lobe compared with elsewhere liver. Methods Overall, 555 consecutive patients treated by single tumor less than 3 cm diameter, were enrolled this study, including 20 Among these patients, was S piegel eight paracaval portion another 10 process two. differences local recurrence rate incidence...
Accurate assessment of the coagulated area is imperative to achieve an excellent outcome from percutaneous radiofrequency ablation (PRFA) for treatment hepatocellular carcinoma (HCC). We evaluated efficacy contrast-enhanced ultrasonography (CEUS) with contrast-enhancing agent Sonazoid precisely assessing therapeutic effect PRFA HCC.We enrolled 87 consecutive patients solitary naïve HCC less than 3 cm in diameter. was performed a 17-G cool-tip needle, and CEUS assess ablative margin h after...
Obesity-related metabolic abnormalities, including adipokine imbalance and chronic inflammation, are involved in liver carcinogenesis. Chemerin, a novel adipokine, plays critical role adipogenesis, energy metabolism, inflammation. We evaluated the impact of serum chemerin levels on functional reserves hepatocellular carcinoma (HCC) patients recurrence prognosis HCC. This study included 44 with any stage HCC who underwent curative treatment at Gifu Municipal Hospital (Gifu, Japan) between...
The thermally stable Pd/Ge ohmic contacts to n-type GaAs are obtained by a rapid thermal annealing method. Compared the conventional AuGe based metals, surface morphology is smooth with high uniformity of constituent. A small deterioration from 1.01.0× 10−5 Ω cm2 1.2 × observed at 300 °C for 103 h. activation energy was 1.9 eV and lifetime this contact, defined as time 10% deterioration, expected be over 109 years 70 °C. mechanism also discussed, utilizing Auger electron spectroscopy x-ray...
Sequences of long-interspersed elements (LINE-1, L1) make up ∼17% the human genome. De novo insertions retrotransposition-active L1s can result in genetic diseases. It has been recently shown that homozygous inactivation two adjacent genes SLCO1B1 and SLCO1B3 encoding organic anion transporting polypeptides OATP1B1 OATP1B3 causes a benign recessive disease presenting with conjugated hyperbilirubinemia, Rotor syndrome. Here, we examined six Japanese diagnosed syndrome on basis laboratory data...
The enhanced liver fibrosis (ELF) test is a noninvasive method for diagnosing hepatic in patients with nonalcoholic fatty disease (NAFLD). This multicenter cohort study aimed to evaluate the accuracy of ELF and compare it other tests Japan.We analyzed 371 Japanese biopsy-proven NAFLD. We constructed area under receiver operator characteristic curves (AUROC) determine diagnostic accuracies test, Mac-2-binding protein glycosylation isomer (M2BPGi), Fibrosis-4 (FIB-4) index, combinations these...
Agile 3+ and 4 scores, based on liver stiffness measurement (LSM) by transient elastography clinical parameters, were recently reported to be effective in identifying advanced fibrosis cirrhosis nonalcoholic fatty disease (NAFLD). This study aimed validate the utility of these scores Japanese patients with NAFLD.Six hundred forty-one biopsy-proven NAFLD analyzed. The severity was pathologically evaluated one expert pathologist. LSM, age, sex, diabetes status, platelet count, aspartate...
It is widely supposed that there has been no evidence of increased survival in patients with advanced dementia receiving enteral tube feeding. However, more than a few studies have reported harmful outcome from feeding compared to without dementia.This was retrospective study. Nine psychiatric hospitals Okayama Prefecture participated this survey. All inpatients fulfilling the entry criteria were evaluated. subjects suffered difficulty oral intake. Attending physicians thought could not live...