A5065226364- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Microbial infections and disease research
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- RNA Interference and Gene Delivery
- interferon and immune responses
- Animal Disease Management and Epidemiology
- Cytomegalovirus and herpesvirus research
- Immune Response and Inflammation
- Aquaculture disease management and microbiota
- Glycosylation and Glycoproteins Research
- Photosynthetic Processes and Mechanisms
- Chromosomal and Genetic Variations
- Animal Virus Infections Studies
- Inflammatory Myopathies and Dermatomyositis
- Genomics and Phylogenetic Studies
- Reproductive System and Pregnancy
- CRISPR and Genetic Engineering
- Hematopoietic Stem Cell Transplantation
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Light effects on plants
Nagoya University
2025
Tokai University
2015-2024
Tokai University Hospital
2024
Universität Hamburg
2024
University Medical Center Hamburg-Eppendorf
2024
Kyoto University
1994-2023
Suzuki (Japan)
2016
Keio University
2016
National Center of Neurology and Psychiatry
2016
Kyoto Prefectural University
2008-2014
Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution the origin vertebrates, we intensively searched for particular genes, gene families, conserved noncoding elements in sequenced genome cephalochordate Branchiostoma floridae, commonly called amphioxus or lancelets. Special attention was given to homeobox opsin genes involved neural crest development, nuclear receptor encoding components...
Induced pluripotent stem cells (iPSCs) provide the potential for autologous transplantation using derived from a patient's own cells. However, immunogenicity of iPSCs or their derivatives has been matter controversy, and up to now there no direct comparison allogeneic in brains humans nonhuman primates. Here, primates, we found that iPSC-derived neurons elicited only minimal immune response brain. In contrast, allografts caused an acquired with activation microglia (IBA-1(+)/MHC class II(+))...
The banking of human leukocyte antigen (HLA)-homozygous-induced pluripotent stem cells (iPSCs) is considered a future clinical strategy for HLA-matched cell transplantation to reduce immunological graft rejection. Here we show the efficacy major histocompatibility complex (MHC)-matched allogeneic neural grafting in brain, which less immune-responsive tissue, using iPSCs derived from an MHC homozygous cynomolgus macaque. Positron emission tomography imaging reveals neuroinflammation...
Abstract The corneal endothelium maintains transparency; consequently, its dysfunction causes severe vision loss. Tissue engineering-based therapy, as an alternative to conventional donor transplantation, is anticipated provide a less invasive and more effective therapeutic modality. We conducted preclinical study for cell-based therapy in primate model demonstrated regeneration of the following injection cultured monkey endothelial cells (MCECs) or human CECs (HCECs), combination with Rho...
Highlights•We established RPE cells from iPSCs in MHC homozygote animals•MHC-mismatching transplantation caused immune attacks of iPS-RPE allografts•MHC-matching appeared to prevent the allografts•T responded allogeneic iPS-RPE, but failed respond RPESummaryThere is an ongoing controversy as whether major histocompatibility complex (MHC) matching a solution for stem cell transplantation. In present study, we retinal pigment epithelial (RPE) induced pluripotent (iPSCs) donors. We observed no...
Abstract Current human leukocyte antigen (HLA) DNA typing methods such as the sequence‐based ( SBT ) and sequence‐specific oligonucleotide SSO generally yield ambiguous results because of probe design limitations or phase ambiguity for HLA allele assignment. Here we describe development application super high‐resolution single‐molecule SS‐SBT loci at 8‐digit level using next generation sequencing NGS ). which can determine an sequence derived from a single molecule is expected to solve...
<h3>Importance</h3> Antisynthetase syndrome, characterized by myositis, interstitial lung disease, skin rash, arthropathy, and Raynaud phenomenon, is a clinical entity based on the presence of aminoacyl transfer RNA synthetase (ARS) antibodies in patients’ serum. However, antisynthetase syndrome not included histological subsets idiopathic inflammatory myopathies. <h3>Objective</h3> To elucidate features myositis patients with syndrome. <h3>Design, Setting, Participants</h3> In this cohort...
The intensely studied MHC has become the paradigm for understanding architectural evolution of vertebrate multigene families. 4-Mb human (also known as HLA complex) encodes genes critically involved in immune response, graft rejection, and disease susceptibility. Here we report continuous 1,796,938-bp genomic sequence class I region, linking between MICB HLA-F . A total 127 or potentially coding sequences were recognized within analyzed sequence, establishing a high gene density one per...
The HLA-Cw6 antigen has been associated with psoriasis vulgaris despite racial and ethnic differences. However, it remains unclear whether is the itself or a closely linked, hitherto unidentified, locus that predisposes to disease. Here, in order map susceptibility for precisely within HLA class I region, 11 polymorphic microsatellite markers distributed throughout 1060 kb segment surrounding HLA-C were subjected association analysis Japanese patients. Statistical analyses of distribution...
We mapped two different quail Mhc haplotypes and sequenced one of them (haplotype A) for comparative genomic analysis with a previously haplotype the chicken Mhc. The A spans 180 kb sequence, encoding total 41 genes compared only 19 within 92-kb Except gene families (B30 tRNA), both species have same basic set family members that were described in "minimal essential" regions similar overall organization but differ markedly has an expanded number duplicated 7 class I, 10 IIB, 4 NK, 6 lectin,...
Abstract MHC haplotypes have a remarkable influence on whether tumors form following infection of chickens with oncogenic Marek’s disease herpesvirus. Although resistance to tumor formation has been mapped subregion the chicken MHC-B region, gene or genes responsible not identified. A full map lacking. We expanded region beyond 92-kb core previously reported for another haplotype revealing presence 46 within 242 kb in Red Jungle Fowl haplotype. Even though is structured differently, many...
We have determined the sequence of a 4-Mb interval on rat chromosome 20p12 that encompasses major histocompatibility complex (MHC). This is first report finished for segment genome and constitutes one largest contiguous sequences thus far rodent genomes in general. The MHC is, next to human MHC, second mammalian sequenced completion. Our analysis has resulted identification at least 220 genes located within interval. Although gene content order are well conserved class II III intervals as...