A5087070892- Long-Term Effects of COVID-19
- Acute Ischemic Stroke Management
- Atrial Fibrillation Management and Outcomes
- Peripheral Neuropathies and Disorders
- Cardiac Arrhythmias and Treatments
- Myasthenia Gravis and Thymoma
- Autoimmune Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- RNA regulation and disease
- Clinical practice guidelines implementation
- Psychosomatic Disorders and Their Treatments
- Neurological disorders and treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Infectious Encephalopathies and Encephalitis
- Dental Erosion and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac pacing and defibrillation studies
- Stroke Rehabilitation and Recovery
- Viral Infections and Vectors
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Medical Malpractice and Liability Issues
- Hereditary Neurological Disorders
- Vector-borne infectious diseases
- CRISPR and Genetic Engineering
National Center of Neurology and Psychiatry
2022-2025
Hamari Chemicals (Japan)
2022-2025
Hamamatsu University School of Medicine
2024
Tokyo National Hospital
2023
Osaka University of Human Sciences
2022
Saitama Medical University
2016-2020
Saitama International Medical Center
2019-2020
Nagasaki Institute of Applied Science
2020
Mito Red Cross Hospital
2012-2014
University of Alabama at Birmingham
2011-2012
Clinical manifestations of Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), include erythema migrans, neuroborreliosis (LNB), carditis, and arthritis. LB is a notifiable disease in Japan with <30 surveillance-reported cases annually, predominately from Hokkaido Prefecture. However, LB, including LNB, may be under-diagnosed since diagnostic tests are not readily available. We sought to determine if LNB could cause previously undiagnosed encephalitis or meningitis...
The association between psychiatric symptoms in Lewy body disease (LBD) and the noradrenergic serotonergic systems is still controversial. This study investigated quantitative relationships of depression delusion with these systems.We studied 24 postmortem tissues from individuals a pathological diagnosis LBD sufficient clinical history. numbers neurons bodies (LBs) locus coeruleus (LC) dorsal raphe nucleus (DRN) were counted, density DRN was analyzed. In addition, densities tryptophan...
CLCN2-related leukoencephalopathy (CC2L) is a rare autosomal recessive disorder caused by biallelic variants of CLCN2, which encodes chloride channel 2. Although CC2L associated with distinct radiological features, it presents wide range clinical features. A 34-year-old woman presented to our hospital sudden onset vertigo headache. The patient reported intermittent headaches and tingling in both arms since the age 31 years. On first visit, was alert neurologically intact, except for slight...
We analyzed 82 single-fiber EMG (SFEMG) tests in the extensor digitorum communis muscle 30 Lambert-Eaton myasthenic syndrome (LEMS) patients to study relationship between electrodiagnostic findings and clinical severity.The repetitive nerve stimulation test was performed abductor digiti quinti flexor carpi ulnaris muscles. SFEMG using conventional method.Fiber density normal all patients. Jitter abnormal at first evaluation regardless of severity. The jitter increasingly with worsening...
In this investigation we report on the clinical utility of sensory nerve conduction studies medial femoral cutaneous (MFC) nerve.Sensory MFC was assessed in 22 patients for whom test considered clinically necessary.MFC abnormal 4 cases neuropathy. The most common cause iatrogenic 14 neuropathy cases. showed absent or low-amplitude action potential (SNAP) 13 cases, with motor 5 2 acute lumbar plexopathy, SNAP unilaterally. normal 1 case diabetic radiculopathy and another postpolio...
The clinical course, comorbidity, and management of symptoms after the acute phase coronavirus disease 2019 (COVID-19) remain controversial. This was a descriptive case series study, examining characteristics patients with longstanding related to COVID-19 who visited our outpatient clinic between 1 June 31 December 2021. We analyzed patients' background, chief complaints, course onset, examination results. A total 90 mean age 39.8 years were confirmed as having long COVID. median time...
Tick-borne encephalitis (TBE) is an infection of the central nervous system caused by tick-borne virus (TBEV). TBE endemic in parts Europe and Asia. TBEV transmitted to humans primarily Ixodes ticks. There have been 5 cases identified Japan, all on northern island Hokkaido. Rodents with antibodies ticks throughout indicating that might be undiagnosed Japan. Residual serum cerebrospinal fluid (CSF) collected 2010-2021 from 520 patients ≥1 year-of-age previously hospitalized or meningitis...
In 2024, the sequalae of acute phase coronavirus disease-19 (COVID-19) infection, which include neurological symptoms and are commonly referred to as long COVID or post-acute sequelae severe respiratory syndrome 2 (SARS-CoV-2) (PASC), continue be a substantial health concern; however, similar observed in individuals with no previous COVID-19 infection.
Interferon (IFN), which is an established maintaining therapy for multiple sclerosis (MS), has been reported various adverse effects. This paper describes a case of IFN-associated retinopathy, representing overlooked effect in MS. A 46-year-old woman with diabetes mellitus was diagnosed MS and treated IFNβ-1b three years. She displayed sudden defect the visual field ocular fundi showed retinal cotton wool spots indicating IFN-retinopathy, resolved rapidly after IFN discontinued. To evaluate...
BackgroundzzLambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic of small cell lung carcinoma (SCLC).Three cases seronegative myasthenia gravis (MG) and SCLC were previously reported.Case ReportzzA 65-year-old man developed severe progressive respiratory failure with clinical features MG.Tests showed decremental response in the repetitive nerve stimulation test, abnormal single-fiber electromyography, positive acetylcholine receptor antibody.SCLC was confirmed by...
Dolichoectasia of the cerebral artery, a rare disorder arterial elongation, dilatation, and tortuosity, usually involves vertebrobasilar system in elderly patients with hypertension is associated development atherosclerosis aging process. We present very case 17-year-old girl multiple sclerosis dolichoectasia supraclinoid segment internal carotid artery that was found incidentally on magnetic resonance angiography seems to represent congenital malformation.
Abstract Introduction: Methods: We compared the problems or complications associated with electrodiagnostic testing in 77 patients implanted cardiac devices. Thirty tests were performed after magnet placement, and 47 without application. Results: All safely all any serious effect on devices placement. A significantly higher number of patient symptoms procedure changes reported group ( P < 0.013). No statistical difference was found difficulty ECG changes. Conclusion: The had an...
A continuous-flow quaternization–substitution reaction of gramines with a chiral nucleophilic glycine equivalent has successfully been developed to achieve rapid and efficient syntheses tryptophan derivatives.
Superficial siderosis (SS) is a rare, neurodegenerative disease that results from toxic accumulation of hemosiderin on the surface brain and spinal cord. The Japanese guidelines for diagnosis classification SS have been classified into three categories, according to distribution iron deposition clinical symptoms, as follows: "classical" type, "localized" type "atypical" type. In SS, patients typically present with slowly progressive irreversible cerebellar ataxia, sensorineural hearing loss,...
Objective Decompressive craniectomy (DC) in patients with malignant middle cerebral artery (MCA) infarction is known to decrease the mortality rate. However, functional outcomes (communication and oral intake) of this procedure remain unclear. Most MCA exhibit a loss consciousness, which may be principally governed by thalamus. We herein investigated DC at 90 days after onset their association preoperative thalamus deformation, can occur due pressure edema. Methods Twelve 2,692 acute were...
<title>Abstract</title> Background <italic>CLCN2</italic>-related leukoencephalopathy (CC2L) is a rare autosomal recessive disorder caused by biallelic variants of <italic>CLCN2</italic> encoding chloride channel 2 (ClC-2) which one the nine chloride-transporting proteins in ClC family. Although CC2L associated with distinct radiological features, it presents wide range clinical features. Case presentation A 34-year-old woman presented to our hospital sudden onset vertigo headache. The...
要旨：近年，脳卒中に関連する診療ガイドラインが公開され，医療現場において利用されている．「脳卒中治療診療ガイドライン」が判決文中引用されている裁判例のうち判決文全文が入手可能で脳卒中の診療が争点となった裁判例について検討した．対象は7 事例（8 裁判例）あり，判決の理由中ガイドラインが過失判断において引用された場合，おおむねガイドライン通りの認定がなされていた．特にガイドライン中，エビデンスレベルが引用されている判決が目立った．民事訴訟はその制度的特性から必ずしも客観的な医学的妥当性は担保されていないものの，民事訴訟での医学的妥当性を必要最低限担保するためにガイドラインが寄与しうる余地がある．