A5014041012- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Peripheral Nerve Disorders
- Hereditary Neurological Disorders
- Parkinson's Disease and Spinal Disorders
- Nerve Injury and Rehabilitation
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Advanced DC-DC Converters
- Orthopedic Surgery and Rehabilitation
- Muscle activation and electromyography studies
- Neurological disorders and treatments
- Multilevel Inverters and Converters
- Genetic Neurodegenerative Diseases
- Inflammatory Myopathies and Dermatomyositis
- Botulinum Toxin and Related Neurological Disorders
- Induction Heating and Inverter Technology
- Multiple Sclerosis Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Autoimmune Neurological Disorders and Treatments
- Cervical and Thoracic Myelopathy
- Ophthalmology and Eye Disorders
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Neurological and metabolic disorders
Teikyo University
2016-2025
Mitsui Memorial Hospital
2016-2018
Fukushima Medical University
2018
Tokyo Teishin Hospital
2018
National Defense Medical College
2018
Teikyo University Hospital
2013-2017
Toyooka Hospital
2016-2017
The University of Tokyo
2016
Kyoto University
2016
University of Alabama at Birmingham
2005-2012
Interferon-β-1b (IFNβ-1b) has been used to prevent exacerbation of relapsing-remitting multiple sclerosis (RRMS) including optic-spinal (OSMS) in Japan. We encountered 2 patients with OSMS unexpectedly severe soon after the initiation IFNβ-1b therapy. The experience urged us retrospectively review RRMS who had treated identify similar cases.At neurologic departments 9 hospitals, medical records 56 were reviewed those showed therapy.Of RRMS, we identified 7 experienced (exacerbation increased...
Abstract Previous studies suggest that in amyotrophic lateral sclerosis (ALS) the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) are more severely involved than digiti minimi (ADM). To elucidate pattern, frequency, extent, specificity of such dissociated muscle atrophy ALS, compound action potentials recorded from APB, FDI, ADM were analyzed 77 ALS patients, 171 normal controls, 196 disease controls. Compared with patients had a reduced APB/ADM amplitude ratio ( P <...
<h3>Objective:</h3> We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation anti–transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker cancer association. <h3>Methods:</h3> retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 pretreatment biopsy samples available. For classification IIMs, European Neuromuscular Center criteria were applied. Patients CAM (anti-TIF1-γ-Ab[+]...
<h3>Importance</h3> The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin be promising agent. <h3>Objective</h3> To validate the efficacy and safety patients with ALS enrolled within 1 year onset. <h3>Design, Setting, Participants</h3> This was multicenter, placebo-controlled, double-blind, randomized phase 3 clinical trial 12-week observation...
Abstract The purpose of this study was to investigate the clinical and electrophysiological efficacy 3,4‐diaminopyridine (DAP) in patients with Lambert–Eaton myasthenic syndrome (LEMS) a randomized, double‐blind, cross‐over drug trial. diagnosis LEMS made based on combination fluctuating muscle weakness, diminished or absent reflexes, more than 60% increment compound action potential (CMAP) amplitude after brief exercise 50‐H Z stimulation repetitive nerve (RNS) test. Evaluations were done...
Patients with seronegative myasthenia gravis (MG) often harbor antibodies for muscle-specific tyrosine kinase (MuSK).1 Nonresponsiveness or poor tolerability of anticholinesterase therapy has been mentioned in reports this population2,3 but not comprehensively studied. We report nonresponsiveness 14 MuSK-antibody (Ab) positive patients seen at the University Alabama Birmingham (UAB) and Texas Southwestern Medical Center (UTSW), comparing them to MuSK-Ab-negative acetylcholine receptor...
The role of fasciculation potentials (FPs) in the diagnosis amyotrophic lateral sclerosis (ALS) has been underrated. Awaji algorithm restored value FPs. Our aim was to test diagnostic yield algorithm, with consideration FPs.Subjects consisted 139 consecutive ALS patients retrospectively enrolled over 5 years. At presentation we evaluated categories using revised El Escorial Criteria (R-EEC) and algorithm.The percentage classified as confirmed ALS, clinically probable (laboratory-supported),...
Abstract Aims/hypothesis Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of make distinct contributions to overall control insulin secretion. These include subpopulation highly connected ‘hub’ cells, important for propagation intercellular Ca 2+ waves. Functional subpopulations have also been demonstrated in human beta with an altered subtype distribution apparent type 2 diabetes. At present, molecular mechanisms through which cell...
To better define electrophysiological abnormalities in myasthenia gravis (MG) patients with muscle-specific tyrosine kinase (MuSK) antibodies (Ab), we compared features of 14 MuSK Ab-positive, 73 acetylcholine receptor antibody (AChR Ab)-positive, and 22 AChR Ab-negative (seronegative) generalized disease. Repetitive nerve stimulation (RNS) were observed 86% Ab-positive 82% but only 55% seronegative patients. RNS decrements the orbicularis oculi more common severe than other two groups....
Abstract Needle electromyography (EMG) of the tongue is traditionally used as a key to diagnosis amyotrophic lateral sclerosis (ALS), although relaxation often difficult achieve. Recently, frequent abnormalities in EMGs sternocleidomastoid (SCM) and upper trapezius muscles ALS have been reported. To elucidate diagnostic utility these we performed multicenter prospective study examine (genioglossus), SCM, 104 or suspected patients. We also examined SCM 32 cervical spondylosis (CS) mainly...
We examined whether stair climbing-descending exercise (ST-EX), a convenient method to increase physical activity in daily life, for short period would acutely improve the postprandial blood glucose (BG) response people with type 2 diabetes (T2D).16 T2D (age 65.4±1.1 years) participated separate sessions. After an overnight fast, each participant consumed test meal and then kept resting 180 min, except when performing 3 min bout of ST-EX at 60 120 after (ST-EX session), or (REST session)....
Abstract An incremental response after brief exercise or high‐rate stimulation on the repetitive nerve (RNS) test is a critical diagnostic criterion for Lambert–Eaton myasthenic syndrome (LEMS). This prospective study was performed to determine what duration of shows highest sensitivity LEMS. The compound muscle action potential amplitude in abductor digiti quinti obtained at rest and 5 s, 10 15 20 25 30 s exercise. Incremental responses were compared different durations 24 studies nine LEMS...
<h3>Objective</h3> To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology shares clinicopathologic characteristics IM induced by immune checkpoint inhibitors (ICIs). <h3>Methods</h3> We analyzed the features of 10 patients MG identified in 970 consecutive biopsy-proven IM. <h3>Results</h3> Seven (70%) had thymoma. were diagnosed more than 5-year time difference 6 thymomatous within 1 year...
To document the utility of decremental responses in repetitive nerve stimulation test (RNS) and spontaneous activities needle electromyography (EMG) trapezius muscle for diagnosis amyotrophic lateral sclerosis.
In order to determine whether there is any difference between voltage-gated calcium-channel antibody (VGCC-Ab)-positive and -negative groups in Lambert-Eaton myasthenic syndrome (LEMS), we compared the clinical electrophysiological features 13 patients with VGCC-Ab 6 VGCC-Ab-negative patients. No obvious was observed various or findings on single-fiber electromyography seropositive seronegative cases. cases, compound muscle action potential (CMAP) amplitude lower but increment post-exercise...
Demographic, clinical, and laboratory features were compared in 235 white African-American (AA) patients with myasthenia gravis (MG) at the University of Alabama Birmingham Neuromuscular Disease Clinic from May 2003 to January 2008. Seventy nine percent white. Acetylcholine receptor antibody was positive 71% 59% AA. In seronegative generalized MG, rate muscle-specific tyrosine kinase (MuSK-Ab) significantly higher AA than it whites (50% vs. 17% whites). Ocular MG 75% patients. AA, occurred...
To identify the gene mutation of tubular aggregate myopathy (TAM) and gain mechanistic insight into pathogenesis disorder.We described a family affected by autosomal dominant TAM performed exome Sanger sequencing to mutations. We further analyzed functional significance identified expression studies intracellular Ca(2+) measurements.A 42-year-old man presented with slowly progressive muscle weakness atrophy in all 4 limbs trunk. Muscle biopsy microscopic examination revealed aggregates his...