A5057635419- Peripheral Nerve Disorders
- Peripheral Neuropathies and Disorders
- Muscle activation and electromyography studies
- Neurogenetic and Muscular Disorders Research
- Myasthenia Gravis and Thymoma
- Hereditary Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Neurological disorders and treatments
- Nerve Injury and Rehabilitation
- Botulinum Toxin and Related Neurological Disorders
- Orthopedic Surgery and Rehabilitation
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Parkinson's Disease and Spinal Disorders
- Pain Mechanisms and Treatments
- Inflammatory Myopathies and Dermatomyositis
- Transcranial Magnetic Stimulation Studies
- Cervical and Thoracic Myelopathy
- Muscle Physiology and Disorders
- EEG and Brain-Computer Interfaces
- Neurology and Historical Studies
- Motor Control and Adaptation
- Spine and Intervertebral Disc Pathology
- Ophthalmology and Eye Disorders
Teikyo University
2016-2025
Deleted Institution
2023
Teikyo University Hospital
2009-2020
Mitsui Memorial Hospital
2016-2017
Ministry of Health Labour and Welfare
2016
Toranomon Hospital
2016
National Center of Neurology and Psychiatry
2016
National Defense Medical College
2008-2016
Showa University
2016
Dokkyo Medical University
2016
Abstract Previous studies suggest that in amyotrophic lateral sclerosis (ALS) the abductor pollicis brevis (APB) and first dorsal interosseous (FDI) are more severely involved than digiti minimi (ADM). To elucidate pattern, frequency, extent, specificity of such dissociated muscle atrophy ALS, compound action potentials recorded from APB, FDI, ADM were analyzed 77 ALS patients, 171 normal controls, 196 disease controls. Compared with patients had a reduced APB/ADM amplitude ratio ( P <...
<h3>Objective:</h3> We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation anti–transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker cancer association. <h3>Methods:</h3> retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 pretreatment biopsy samples available. For classification IIMs, European Neuromuscular Center criteria were applied. Patients CAM (anti-TIF1-γ-Ab[+]...
<h3>Objective:</h3> To show cancer association is a risk factor other than statin exposure for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase autoantibody-positive (anti-HMGCR Ab+) myopathy. <h3>Methods:</h3> We analyzed the clinical features and courses of 33 patients (23 female 10 male) with anti-HMGCR Ab+ myopathy among 621 consecutive idiopathic inflammatory myopathies. <h3>Results:</h3> Among patients, 7 (21%) were statin-exposed 26 statin-naive. In relation cancer, there 12...
<h3>Importance</h3> The effectiveness of currently approved drugs for amyotrophic lateral sclerosis (ALS) is restricted; there a need to develop further treatments. Initial studies have shown ultrahigh-dose methylcobalamin be promising agent. <h3>Objective</h3> To validate the efficacy and safety patients with ALS enrolled within 1 year onset. <h3>Design, Setting, Participants</h3> This was multicenter, placebo-controlled, double-blind, randomized phase 3 clinical trial 12-week observation...
The role of fasciculation potentials (FPs) in the diagnosis amyotrophic lateral sclerosis (ALS) has been underrated. Awaji algorithm restored value FPs. Our aim was to test diagnostic yield algorithm, with consideration FPs.Subjects consisted 139 consecutive ALS patients retrospectively enrolled over 5 years. At presentation we evaluated categories using revised El Escorial Criteria (R-EEC) and algorithm.The percentage classified as confirmed ALS, clinically probable (laboratory-supported),...
Guillain-Barré syndrome (GBS) is an acute monophasic neuropathy. Prognostic tools include the modified Erasmus GBS outcome score (mEGOS), respiratory insufficiency (EGRIS), and increase in serum IgG levels (ΔIgG) 2 weeks after intravenous immunoglobulin (IVIg) treatment. Given that proportions of subtypes differ between Western countries Japan, usefulness these Japan or other remains unknown. We enrolled 177 Japanese patients with from 15 university hospitals retrospectively obtained mEGOS...
Abstract Needle electromyography (EMG) of the tongue is traditionally used as a key to diagnosis amyotrophic lateral sclerosis (ALS), although relaxation often difficult achieve. Recently, frequent abnormalities in EMGs sternocleidomastoid (SCM) and upper trapezius muscles ALS have been reported. To elucidate diagnostic utility these we performed multicenter prospective study examine (genioglossus), SCM, 104 or suspected patients. We also examined SCM 32 cervical spondylosis (CS) mainly...
Background: GM1 and GalNAc-GD1a are located on the axolemma of motor nerves believed to be antigens associated with pure Guillain-Barré syndrome (GBS). Furthermore, may exist nearby colocalize axolemma. Ganglioside complex (GSC) or can target in GBS. We investigated GBS sera for antibodies a GSC consisting (GM1/GalNAc-GD1a) analyzed clinical electrophysiologic findings patients GM1/GalNAc-GD1a.
<h3>Objective</h3> Guillain–Barré Syndrome (GBS) is classified into the two major subtypes; acute inflammatory demyelinating polyneuropathy (AIDP) and motor axonal neuropathy (AMAN). Previous studies have suggested that AIDP predominant AMAN rare in Western countries, whereas not always uncommon East Asia. We aimed to clarify incidence of subtypes GBS Japan. <h3>Methods</h3> performed a prospective multicentre survey over 3 years (2007–2010). Clinical electrophysiological findings were...
ABSTRACT Introduction Extrapolated reference values (E‐Ref) procedure is a new method for determining the cutoff value without collecting control data. We tried to apply this determine distal motor latency of median nerve (median DML). During process, we found two pitfalls E‐Ref method. First, did not correctly work when DML measured with 0.1 ms accuracy frequently took on tie values. Second, result was influenced by proportion abnormal This study investigated these issues. Methods Data were...
The patient was a 78-year-old woman. She underwent foramen magnum decompression for syringomyelia associated with Chiari type I malformation, which had developed difficulty in raising the left upper limb and muscle weakness both limbs. One year after surgery, weight loss of 20 kg, progressive atrophy extremities, paralytic dysarthria, fasciculation bilateral anterior thighs were observed, needle electromyography showed acute denervation chronic medial vastus muscle. rapid postoperative...