A5040734366- Muscle Physiology and Disorders
- Inflammatory Myopathies and Dermatomyositis
- Parkinson's Disease and Spinal Disorders
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Prosthetics and Rehabilitation Robotics
- Gaze Tracking and Assistive Technology
- Amyotrophic Lateral Sclerosis Research
- Hereditary Neurological Disorders
- Cardiovascular Function and Risk Factors
- Infrared Thermography in Medicine
- Glycogen Storage Diseases and Myoclonus
- Pancreatic function and diabetes
- GDF15 and Related Biomarkers
- Soft tissue tumor case studies
- Mast cells and histamine
- Infectious Diseases and Tuberculosis
- Cervical and Thoracic Myelopathy
- Advanced Sensor and Energy Harvesting Materials
- Galician and Iberian cultural studies
- Muscle activation and electromyography studies
- Cardiovascular Effects of Exercise
National Hospital Organization
2011-2025
Shizuoka City Shimizu Hospital
2010-2024
<h3>Objective:</h3> We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation anti–transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker cancer association. <h3>Methods:</h3> retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 pretreatment biopsy samples available. For classification IIMs, European Neuromuscular Center criteria were applied. Patients CAM (anti-TIF1-γ-Ab[+]...
To document the utility of decremental responses in repetitive nerve stimulation test (RNS) and spontaneous activities needle electromyography (EMG) trapezius muscle for diagnosis amyotrophic lateral sclerosis.
Abstract Objectives The clinicopathological features of immune-mediated necrotizing myopathy (IMNM) sometimes mimic muscular dystrophy, complicating accurate diagnosis. European League Against Rheumatism (EULAR)/American College Rheumatology (ACR) classification criteria idiopathic inflammatory myopathies (IIMs) are superior in terms sensitivity and specificity; however, the is reported to be relatively low IMNM. We examined characteristics prognoses anti-3-hydroxy-3-methylglutaryl-CoA...
In addition to the pivotal roles of mast cells in allergic diseases, recent data suggest that play crucial a variety autoimmune responses. However, their pathogenesis skeletal muscle diseases have not been clarified despite distribution muscle. Therefore, objective this study is determine development diseases.The number affected was examined patients with dermatomyositis (DM) or polymyositis (PM). The susceptibility cell-deficient WBB6F1-Kit(W)/Kit(Wv) mice (W/W(v) mice) murine model...
Persons with severe Duchenne muscular dystrophy (DMD) cannot operate electric wheelchairs through standard joysticks because they lack power and are affected by deformation of the hands. To address this difficulty, first authors determin
We report on two patients with amyotrophic lateral sclerosis (ALS) complaining of sudden-onset difficulty in finger elevation. A 65-year-old man (the first patient) and a 66-year-old second suddenly became aware elevation one hand. They were not any other symptoms prior to the onset. In patient, cerebral infarction at precentral gyrus was initially suspected. cervical spondylosis suspected, spine surgery planned. However, needle EMG revealed widespread neurogenic changes abundant...
Persons with Duchenne Muscular Dystrophy (DMD) usually have difficult in operating electric wheelchairs (EWs) using standard input device due to the lack of muscular power and deformation their hands. To solve this problem, various kinds devices are developed considering physical limits. However, as disease progresses, persons severe DMD will gradually lose ability operate devices. In study, we first made an investigation functions for found that upper limb, especially fingers, tended remain...
Pathogenic variants of HSPB1, the gene encoding small heat shock protein 27, have been reported to cause autosomal dominant distal hereditary motor neuropathy (dHMN) type II and Charcot-Marie-Tooth (CMT) disease with minimal sensory involvement (CMT2F). This study aimed describe clinical features patients in a family late-onset dHMN carrying Pro39Leu variant HSPB1.Whole-exome sequence analysis identified heterozygous pathogenic (Pro39Leu) HSPB1 proband. The presence two affected individuals...
Human induced pluripotent stem (iPS) cells initiate hepatocyte differentiation in a medium without glucose and supplemented with galactose, oncostatin M small molecules [hepatocyte inducer (HDI)]. To clarify the metabolic differences between iPS HDI ReproFF (undifferentiated state), metabolome analysis was performed. were cultured as well 1 mM of calcium lactate, sodium lactate or lactic acid. After 7 days culture, subjected to reverse transcription‑quantitative PCR analysis. The...