A5077768581- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- HIV/AIDS drug development and treatment
- Peripheral Neuropathies and Disorders
- HIV Research and Treatment
- T-cell and Retrovirus Studies
- Hereditary Neurological Disorders
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Heat shock proteins research
- Neurological diseases and metabolism
- BRCA gene mutations in cancer
- Long-Term Effects of COVID-19
- Vitamin K Research Studies
- PARP inhibition in cancer therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Childhood Cancer Survivors' Quality of Life
- Autoimmune Bullous Skin Diseases
- Parvovirus B19 Infection Studies
- Glycogen Storage Diseases and Myoclonus
- Multiple Myeloma Research and Treatments
The University of Tokyo
2023-2025
Tokyo Teishin Hospital
2023-2024
Kyorin University
2024
AbbVie (Japan)
2020
ABB (Japan)
2020
Toranomon Hospital
2019
National Cancer Center Hospital East
2018
Osaka Medical and Pharmaceutical University
1994
Kansai Medical University
1990
A patient with chronic idiopathic thrombocytopenic purpura (ITP), a 28‐year‐old group A, Rh‐positive woman, also had hemolytic anemia. At that time, her red cells typed as but the serum O. This typing followed intravenous high‐dose immune globulin therapy, (400 mg/kg for 5 successive days) and was attributable to antibody of IgG type, composed IgG1, IgG2, IgG3, IgG4, in preparation, which been given treatment ITP. All lots commercial human plasma preparation products (heat‐treated protein,...
Abstract Background Dropped head syndrome (DHS) is a group of disorders that result in anterior neck flexion. Myasthenia gravis (MG) common cause DHS. Previous reports have suggested concurrent myopathy involving the paraspinal musculature may underlie DHS patients with anti‐acetylcholine receptor antibody‐positive or thymoma‐associated MG. Case Presentation A 64‐year‐old woman presented 3‐month history drop and lordosis. Neurological examination revealed bilateral ptosis weakness posterior...
Longitudinally extensive myelitis with 15 or more vertebrae in length is extremely rare, limited evidence regarding clinical features and therapeutic response. We report a case of 29-year-old male patient longitudinally ultimately diagnosed as myelin oligodendrocyte glycoprotein-associated disease (MOGAD). The presented an acute onset meningismus, limb weakness, sensory disturbance below the C5 level, ataxia, urinary retention. T2-weighted imaging on MRI showed spinal cord lesion ranging...
Congenital hemoglobin disorders typically present as hemolytic anemia, but there are also numerous reports of thrombotic complications in these diseases, suggesting an associated hypercoagulative state. In Köln, the most common type unstable hemoglobinopathy worldwide, have not been many such phenomena. We herein describe case a patient with Köln demonstrating acute cerebral infarction. His father, who had presumably history This suggests that among other congenital disorders, may be...
We tested whether human immunodeficiency virus type 1 (HIV-1) could be differentiated from HIV-2 by a reverse transcriptase (RT)-typing assay that measured the reduction of enzyme activity owing to specific antibody. RT-inhibiting antibody was examined for HIV specificity new nonradioisotopic RT assay. Antibodies four rabbits immunized with recombinant HIV-1 and 23 HIV-1-seropositive individuals all specifically inhibited activities two strains (LAV-1 GH-3), three zidovudine-resistant...
Abstract Introduction Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of the motor system. Pathogenic variants in SPTLC1 , encoding subunit serine palmitoyltransferase, cause hereditary sensory and autonomic neuropathy type 1 (HSAN1), have recently been associated with juvenile ALS. ALS elevated levels sphinganines ceramides. Reports on remain limited. This study aimed to investigate frequency relevant clinical characteristics. Methods We analyzed whole-exome...
Abstract Background Guillain–Barré syndrome (GBS) is an immune‐mediated polyneuropathy most commonly associated with antecedent infections, such as Campylobacter jejuni or viral but vaccination also known event. In recent years, due to the worldwide pandemic, against coronavirus disease 2019 (COVID‐19) has widely spread throughout world. Although surveillance of vaccination‐associated adverse effects still ongoing, multiple cases GBS after COVID‐19 have been reported. However, exact...
Anti-GM1 antibodies are associated with Guillain-Barré syndrome (GBS), primarily peripheral neuropathy. However, there cases of anti-GM1 IgG antibody-positive GBS upper motor neuron (UMN) signs. We herein report a case gastrointestinal infection followed by subacute gait disturbance predominant signs UMN on neurological examination. The serum and cerebrospinal fluid tests were positive for anti-asialo-GM1 antibodies. An electrophysiological evaluation revealed normal nerve conduction...
We investigated 18 anti-HIV seropositive subjects with respect to the isolation of HIV from peripheral blood mononuclear cells (PBMC) and cellular serologic markers for progression AIDS. The included homosexuals recipients products. Three had AIDS, an asymptomatic subject developed AIDS during study 14 remaining have remained asymptomatic.HIV was isolated all patients 7 subjects. Moreover detected significantly sooner in symptomatic than reductions CD4 lymphocytes number CD4/CD8 ratio, as...
Summary. A 24‐year‐old male was admitted to Kansai Medical University Hospital, complaining of fever, skin exanthema, jaundice, brown urine and lymphadenopathy. The patient diagnosed as having haemolytic anaemia caused by a cold agglutinin following rubella infection. the reacted strongly with group OI red blood cells (RBC), Oi cord RBC, adult RBC neuraminidase‐treated much weaker protease (papain, ficin, bromelin)‐treated RBC; it identified anti‐Pr . Cold agglutinins specificity infection...
Abstract Background Pancreatic exocrine insufficiency (PEI) is known to occur after total gastrectomy. We experienced a case of PEI occurring 18 years surgery, leading potentially fatal condition capillary leak syndrome (CLS). Case presentation The 58-year-old man on healthy diet who underwent gastrectomy before. He was admitted for 3-month history anasarca, steatorrhea, and hypoalbuminemia. An episode fever occurred during workup, followed by pulmonary edema shock. patient transferred the...
Pathogenic variants of HSPB1, the gene encoding small heat shock protein 27, have been reported to cause autosomal dominant distal hereditary motor neuropathy (dHMN) type II and Charcot-Marie-Tooth (CMT) disease with minimal sensory involvement (CMT2F). This study aimed describe clinical features patients in a family late-onset dHMN carrying Pro39Leu variant HSPB1.Whole-exome sequence analysis identified heterozygous pathogenic (Pro39Leu) HSPB1 proband. The presence two affected individuals...
Human immunodeficiency virus (HIV)-associated neuropathy is a common complication of HIV infection and has several clinical subtypes. HIV-associated chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) whose features are known to differ from those CIDP in the HIV-uninfected population. We herein report case an HIV-infected patient who was finally diagnosed with anti-neurofascin 155 (NF155) antibody-positive neuropathy. The features, including findings therapeutic responses, were...
We have reported on the investigation of 54 HIV-1 patients concerning isolation and clinical marker in preceding paper. attempted analysis V3 RT genes. from a patient who had rapidly taken turn for worse basic amino acid at position 11 (Arg) lost an acidic 25 (Gin) V3. This sequence pattern was distinguished feature virus with rapid-high, syncytium inducing (SI) T-cell-line tropic phenotype. In contrast, no or mild symptoms sequences characterized as slow-low, non-synsytium (NSI) macrophage...