A5002103423- Inflammatory Myopathies and Dermatomyositis
- Peripheral Neuropathies and Disorders
- Chronic Lymphocytic Leukemia Research
- Hereditary Neurological Disorders
- Skin Diseases and Diabetes
- Myasthenia Gravis and Thymoma
- Peripheral Nerve Disorders
- Autoimmune Neurological Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
- Botulinum Toxin and Related Neurological Disorders
- Muscle Physiology and Disorders
- Herpesvirus Infections and Treatments
- Autoimmune and Inflammatory Disorders Research
- Cancer Diagnosis and Treatment
- Soft tissue tumor case studies
- Genetics and Neurodevelopmental Disorders
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Long-Term Effects of COVID-19
- Neuroscience and Neuropharmacology Research
- Parvovirus B19 Infection Studies
- Autoimmune Bullous Skin Diseases
- Polyomavirus and related diseases
- Thermoregulation and physiological responses
- Full-Duplex Wireless Communications
National Hospital Organization
2017-2025
Self-Defense Forces Central Hospital
2022-2023
National Defense Medical College
2014-2021
Tokyo Teishin Hospital
2016-2018
Mitsui Memorial Hospital
2016-2018
The University of Tokyo
2006-2018
Fukushima Medical University
2018
Teikyo University
2018
Toranomon Hospital
2016-2017
National Center for Global Health and Medicine
2017
<h3>Objective</h3> To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly focusing on fine structures paranodes. <h3>Methods</h3> We assessed sural nerve biopsy specimens obtained from 9 patients CIDP anti-neurofascin-155 antibodies and 1 patient anti-contactin-1 antibodies. 13 without these were also examined to compare pathological findings. <h3>Results</h3>...
<h3>Objective:</h3> We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation anti–transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker cancer association. <h3>Methods:</h3> retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 pretreatment biopsy samples available. For classification IIMs, European Neuromuscular Center criteria were applied. Patients CAM (anti-TIF1-γ-Ab[+]...
<h3>Objective:</h3> To show cancer association is a risk factor other than statin exposure for anti-3-hydroxy-3-methylglutaryl coenzyme A reductase autoantibody-positive (anti-HMGCR Ab+) myopathy. <h3>Methods:</h3> We analyzed the clinical features and courses of 33 patients (23 female 10 male) with anti-HMGCR Ab+ myopathy among 621 consecutive idiopathic inflammatory myopathies. <h3>Results:</h3> Among patients, 7 (21%) were statin-exposed 26 statin-naive. In relation cancer, there 12...
<h3>Objective:</h3> To determine the clinical features of myositis patients with histopathologic finding CD8-positive T cells invading non-necrotic muscle fibers expressing major histocompatibility complex class 1 (CD8-MHC-1 complex), which is shared by polymyositis (PM) and inclusion body (IBM), in relation to p62 immunostaining pattern fibers. <h3>Methods:</h3> All 93 CD8-MHC-1 who were referred our hospital from 1993 2015 classified on basis European Neuromuscular Center (ENMC) diagnostic...
<h3>Objective</h3> To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology shares clinicopathologic characteristics IM induced by immune checkpoint inhibitors (ICIs). <h3>Methods</h3> We analyzed the features of 10 patients MG identified in 970 consecutive biopsy-proven IM. <h3>Results</h3> Seven (70%) had thymoma. were diagnosed more than 5-year time difference 6 thymomatous within 1 year...
We herein describe the case of a 48-year-old woman who presented with nonconvulsive status epilepticus refractory to antiepileptic drugs caused by anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis without any tumors. She developed nausea and psychiatric symptoms, followed fever an acute progressive disturbance consciousness. On admission our hospital, she involuntary orofacial movements central hypoventilation, electroencephalogram showed generalized slow activity consistent...
Abstract Objectives The clinicopathological features of immune-mediated necrotizing myopathy (IMNM) sometimes mimic muscular dystrophy, complicating accurate diagnosis. European League Against Rheumatism (EULAR)/American College Rheumatology (ACR) classification criteria idiopathic inflammatory myopathies (IIMs) are superior in terms sensitivity and specificity; however, the is reported to be relatively low IMNM. We examined characteristics prognoses anti-3-hydroxy-3-methylglutaryl-CoA...
With the expanding use of immune checkpoint blockers typified by anti–programmed death-1 (PD-1) and anti–cytotoxic T-lymphocyte-associated protein 4 monoclonal antibodies (Abs) for antitumor therapy, number patients showing immune-related adverse events (irAEs) is increasing. Skeletal muscle one target tissues irAEs several features myopathy as have been reported: myasthenia gravis (MG) overlap, cardiac involvement, necrotizing myopathy, inflammatory with T-cell B-cell infiltration.1–4...
We describe the case of a 46-year-old man with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis prominent parkinsonism. The patient presented psychiatric symptoms followed by epileptic seizure and parkinsonism including micrographia. Magnetic resonance imaging (MRI) revealed lesions in bilateral medial temporal lobes basal ganglia on fluid-attenuated inversion recovery images. His MRI findings were ameliorated immunotherapy but then relapsed. After retreatment, his gradually improved...
The potential of ozonated water was investigated as an alternative to soil disinfectants in reducing the population densities Fusarium oxysporum f. sp. lycopersici artificially infested quartz sand and Kuroboku columns. Significant reductions density were observed with dissolved ozone concentrations (DOCs) 6 12 mg L−1 but not soil. results indicate that repetitive application higher DOCs should be required for F. soils high content organic substances large surface area.
An 89-year-old woman with type 2 diabetes mellitus presented occasional drowsiness. She had lost >5 kg within 1 week, and her family informed that she become increasingly less responsive. was not engaging in excessive soft drink consumption or taking laxative medication. However, started prednisone 10 mg/day for pruritus week prior to presentation. At the initial assessment, fully conscious without any abnormal vital signs. a glucometer showed >600 mg/dL. A subsequent blood test revealed...
A 5-year-old male Siberian husky bred outdoor in Tokyo had a swollen paw with interdigital granulomatous lesions the left hindlimb. The dog no apparent pulmonary or gastrointestinal involvement. Histopathological analysis of skin demonstrated yeast-like organisms predominantly within macrophages. Sequence fungal ribosome RNA gene isolated from paraffin sample revealed 100% homology teleomorph Histoplasma capsulatum. present case may support concept primary cutaneous canine histoplasmosis as...
Amyloid-like immunoglobulin M (IgM) deposition neuropathy associated with Waldenström macroglobulinemia is a rare phenotype of IgM-related neuropathy. The prominent clinical features are painful sensory-dominant followed by distal motor weakness and atrophy over long course1–4 that refractory to immunosuppressive treatment in many patients.1–6 Herein, we report case amyloid-like IgM was successfully treated rituximab (RTX).
症例は85歳男性である．第1病日，突然物が二重にみえ右眼が外側に偏倚した．歩行時ふらつきと上口唇周囲のピリピリ感もみとめた．症状が持続し第10病日入院．右優位の両眼開散位，交代性外斜視をともなう両側核間性外眼筋麻痺（wall-eyed bilateral internuclear ophthalmoplegia; WEBINO），左上下肢失調，口唇の右上方の異常感覚をみとめた．頭部MRIで橋被蓋傍正中部に限局する脳梗塞あり．発症4ヵ月で小脳失調と顔面感覚障害は軽快したが眼球運動障害は持続した．神経症候から推定される障害範囲は両側内側縦束，左上小脳脚，三叉神経視床路をふくみ，MRI上の梗塞域より広範だった．
We herein report a case of recurrent multifocal, distal-dominant-sensorimotor neuropathy with ophthalmoplegia, IgM anti-GM1 antibody, and pyrexia-associated relapse. The patient developed sensory disturbance in her limbs after febrile disease at 50 years old. She had experienced several similar episodes was admitted to the hospital 56 Based on pathological study electrophysiological findings consistent chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), maintenance IVIg therapy...
A 19-year-old woman developed high fever, headache, and nausea after taking Loxoprofen for pharyngitis, followed by disturbed consciousness nuchal stiffness. The patient her mother had a history of Raynaud's phenomenon. Cerebrospinal fluid (CSF) examination indicated diagnosis aseptic meningitis revealed levels Q albumin IgG index. Anti-RNP antibodies were positive in serum CSF. Her symptoms disappeared immediately cessation drug lymphocyte stimulation test was negative, confirming...
The effect of a non-uniform thermal environment on subjects is studied using an air-conditioned chamber with underfloor air supply and radiator panels. mean equivalent temperature T eq around sitting intentionally varied, boards placed at waist level allow various combinations upper lower to be realised. Thermal sensation comfort votes are analysed for the whole body, body body. In winter, female tolerated cold over summer, experiment, generally felt comfortable whenever was 26°C difference...
症例は小学校の入学時検診で右感音性難聴を指摘され，原因不明の感音性難聴の診断で経過観察されていた15歳女子である．15歳時に聴覚器精査のため施行した頭部MRIで側脳室周囲深部白質に高信号病変を認めた．血液，脳脊髄液，全脊髄MRIに異常はなく，ウェクスラー成人知能検査では言語性IQ，動作性IQともに正常であったが，難聴，大脳深部白質病変の存在から先天性サイトメガロウイルス（cytomegalovirus; CMV）感染を疑い，保存臍帯を用いたPCR法でCMV-DNAが検出され診断が確定した．知能正常の先天性CMV感染は見逃されている可能性があり，難聴や深部白質病変が診断の契機となりうる．
A 55-year-old woman was admitted to our hospital because of gait disturbance and urinary retention that acutely emerged 1 week after severe acute respiratory syndrome coronavirus 2 infection. Acute inflammatory myelopathy clinically suspected, based on bilateral lower-limb weakness with an extensor plantar response elevated immunoglobulin G level in the cerebrospinal fluid. Whole-spine magnetic resonance imaging findings were normal. The central conduction time extended, somatosensory evoked...