A5101482460- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Glycosylation and Glycoproteins Research
- Head and Neck Surgical Oncology
- Sleep and Wakefulness Research
- Anatomy and Medical Technology
- Fetal and Pediatric Neurological Disorders
- Cardiac Ischemia and Reperfusion
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Neurobiology of Language and Bilingualism
Jichi Medical University
2016-2025
Jichi Medical University Hospital
2016-2025
Osaka University
2024
The University of Tokyo
2009-2023
NTT Medical Center
2014-2022
SAS Institute (United States)
2019
Environmental Systems Research Institute (United States)
2019
NTT (United States)
2015
University of Tokyo Hospital
1998-2014
Hospital Regional de Alta Especialidad del Bajío
2014
Object To validate the corticospinal tract (CST) illustrated by diffusion tensor imaging, authors used tractography-integrated neuronavigation and direct fiber stimulation with monopolar electric currents. Methods Forty patients brain lesions adjacent to CST were studied. During operation, motor responses (motor evoked potential [MEP]) elicited at hand cortical area continuously monitored, maintaining consistent stimulus intensity (mean 15.1 ± 2.21 mA). lesion resection, was applied elicit...
We hypothesized that expert epileptologists can detect seizures directly by visually analyzing EEG plot images, unlike automated methods analyze spectro-temporal features or complex, non-stationary of signals. If so, seizure detection could benefit from convolutional neural networks because their visual recognition ability is comparable to humans. explored image-based applying long-term included epileptic seizures. After filtering, data were divided into short segments based on a given time...
Abstract Aims . Vagus nerve stimulation (VNS) is an established option of adjunctive treatment for patients with drug‐resistant epilepsy, however, evidence long‐term efficacy still limited. Studies on clinical outcomes VNS in Asia are also We report the overall outcome a national, prospective registry that included all implanted Japan. Methods The ages seizure types who underwent implantation epilepsy first three years after approval 2010. excluded were expected to benefit from resective...
Light microscopic neuronal changes were studied in rats subjected to 10 min of global ischemia produced by compression the major cardiac vessels. Observations cresyl violet-stained sections revealed early involving predominantly GABAergic neurons various locations. In killed 15 after recirculation, characterized appearance a clear peripheral zone with condensation remaining cytoplasm. After 1 h, these zones appeared be compartmentalized into individual pearl-like vacuoles, especially...
The ability of EUS to diagnose small pancreatic cancer is well known. In this study, we present our experience with in the local staging 29 patients carcinoma who underwent surgery. was 79, 83 and 79 % accurate determining anterior (including gastric), duodenal retroperitoneal (vascular) invasion by tumor. Ultrasonography (48, 39 55 %, respectively) CT (38, 33 41 were less reliable. equal angiography diagnosing vascular involvement. more effective detecting splenoportal infiltration...
<h3>Objectives</h3> This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. <h3>Methods</h3> We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) were urgently hospitalized at 621 institutions in Japan between April 2010 March 2015. compared DOAC- warfarin-treated...
It will contribute to the development of sustainable artificial intelligence elucidate mechanism neural modulation by which brain a living organism enable stable information processing in response constantly changing external environments and internal states. As one such cortical modulation, present study focused on effect vagus nerve stimulation (VNS) therapy representation auditory cortex. By quantifying sound using machine learning, we investigated whether VNS alters layer-specific...
Object. The purpose of this study was to present a combinatorial approach used develop subarachnoid hemorrhage (SAH) grading scale based on the patient's preoperative Glasgow Coma Scale (GCS) score. Methods. There are 4094 different combinations that can be compress 13 scores GCS into two 12 grades. Break points, positions in which adjacent connote significantly outcome, obtained by direct comparison and Outcome (GOS). Guided break number considered limited. All possible statistically...
Abstract OBJECTIVE: It has been difficult to obtain anatomic and functional information about the visual pathway during neurosurgical operations. The aim of this study was combine evoked potentials (VEPs) navigation optic radiation by diffusion tensor imaging-based tractography for monitoring pathway. METHODS: subjects were two patients with brain lesions adjacent Diffusion performed selecting appropriate regions interest fractional anisotropy. During surgery, cortical VEPs recorded...
OBJECTIVE It is known that functional magnetic resonance imaging (fMRI) and magnetoencephalography (MEG) are sensitive to the frontal temporal language function, respectively. Therefore, we established combined use of fMRI MEG make reliable identification global dominance in pathological brain conditions. METHODS We investigated 117 patients with lesions whose was successfully confirmed by Wada test. All were asked generate verbs related acoustically presented nouns (verb generation) for...
Objectives To develop an in vitro model for studying the biological effect of complex-flow stress on endothelial cells three-dimensional (3D) patient-specific vascular geometry. Materials and methods A vessel replica was fabricated with polydimethylsiloxanes using 3D printing technology from image data acquired by rotational angiography. The coated fibronectin immersed a tube filled cell suspension endothelium, then cultured while being slowly rotated three dimensions. Culture medium...
Abstract Patient-specific vascular replicas are essential to the simulation of endovascular treatment or for research. The inside silicone replica is required be smooth manipulating interventional devices without resistance. In this report, we demonstrate fabrication patient-specific vessels with a low-cost desktop 3D printer. We show that surface an acrylonitrile butadiene styrene (ABS) model printed by printer can smoothed single dipping in ABS solvent time-dependent manner, where short...
Abstract Gamma oscillations are physiological phenomena that reflect perception and cognition, involve parvalbumin-positive γ-aminobutyric acid-ergic interneuron function. The auditory steady-state response (ASSR) is the most robust index for gamma oscillations, it impaired in patients with neuropsychiatric disorders such as schizophrenia autism. Although ASSR reduction known to vary terms of frequency time, neural mechanisms poorly understood. We obtained high-density electrocorticography...
Intraoperative monitoring of visual evoked potentials (VEPs) has been regarded as having limited significance for the preservation function during neurosurgical procedures, mainly due to its poor spatial resolution and signal-to-noise ratio. The authors evaluated usefulness cortically recorded VEPs, instead usual scalp intraoperative focusing on posterior pathway.In 17 consecutive patients who underwent microsurgical procedures lesions near pathway, cortical responses were using 1-Hz...
Electrocorticography (ECoG), multichannel brain-surface recording and stimulation with probe electrode arrays, has become a potent methodology not only for clinical neurosurgery but also basic neuroscience using animal models. The highly evolved primate's brain deep cerebral sulci, both gyral intrasulcal cortical regions have been implicated in important functional processes. However, direct experimental access is typically limited to regions, since placing probes into sulci difficult...
Background and Purpose: We analyzed the ability of a machine learning approach that uses diffusion tensor imaging (DTI) structural connectomes to determine lateralization epileptogenicity in temporal lobe epilepsy (TLE).Materials Methods: 3-dimensional (3D) T1-weighted images 44 patients with TLE (right, 15, left, 29; mean age, 33.0 ± 11.6 years) 14 age-matched controls. constructed whole brain connectome for each subject, calculated graph theoretical network measures, used support vector...
Abstract Auditory contextual processing has been assumed to be based on a hierarchical structure consisting of the primary auditory cortex, superior temporal gyrus (STG), and frontal lobe. Recent invasive studies mismatch negativity (MMN) have revealed functional segregation for such as neural adaptation in cortex prediction However, role STG remains unclear. We obtained induced activity high gamma band response (MMR), an electrocorticographic (ECoG) counterpart scalp MMN, components MMR by...
Abstract: Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation. The present study compared quinolinate responses to systemic and activation gerbils rats. Global cerebral ischemia gerbils, but not rats, increased hippocampus indoleamine‐2,3‐dioxygenase activity levels 4 days postinjury. In a rat focal model, small concentrations occurred infarcted regions on 1, 3, 7, although remained below serum values....
BACKGROUND: Functional magnetic resonance imaging (fMRI) is a less invasive way of mapping brain functions. The reliability fMRI for localizing language-related function yet to be determined. OBJECTIVE: We performed detailed analysis language by comparing the results 3-T with maps determined extraoperative electrocortical stimulation (ECS). METHODS: This study was on 8 epileptic patients who underwent subdural electrode placement. tasks during included verb generation, abstract/concrete...
Stereotactic neurosurgery is an established technique, but it has several limitations. In frame-based stereotaxy using a stereotactic frame, frame setting errors may decrease the accuracy of procedure. Frameless neuronavigation requires surgeons to shift their view from surgical field navigation display and advance needle while assuming physically uncomfortable position. To overcome these limitations, researchers have applied augmented reality in neurosurgery. Augmented enables visualize...