A5060269926- Spinal Dysraphism and Malformations
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Advanced Neuroimaging Techniques and Applications
- Head and Neck Surgical Oncology
- Neuroscience and Neuropharmacology Research
- Teratomas and Epidermoid Cysts
- Stroke Rehabilitation and Recovery
- Spinal Cord Injury Research
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Spinal Hematomas and Complications
- Meningioma and schwannoma management
- Gaze Tracking and Assistive Technology
- Congenital Anomalies and Fetal Surgery
- Pharmacological Effects and Toxicity Studies
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Intracranial Aneurysms: Treatment and Complications
Kyushu University
2016-2025
Aso Iizuka Hospital
2023-2024
Fukuoka University
2021
Clinical Research Institute
2018
Nara Medical University
2018
National Cerebral and Cardiovascular Center
2018
Hyogo Medical University
2018
University of Occupational and Environmental Health Japan
2018
Nagoya Medical Center
2018
National Hospital Organization
2018
<h3>Objectives</h3> This cross-sectional survey explored the characteristics and outcomes of direct oral anticoagulant (DOAC)–associated nontraumatic intracerebral hemorrhages (ICHs) by analyzing a large nationwide Japanese discharge database. <h3>Methods</h3> We analyzed data from 2,245 patients who experienced ICHs while taking anticoagulants (DOAC: 227; warfarin: 2,018) were urgently hospitalized at 621 institutions in Japan between April 2010 March 2015. compared DOAC- warfarin-treated...
Magnetic resonance imaging (MRI), including perfusion MRI with arterial spin labeling (ASL) and diffusion-weighted (DWI), are applied in the periictal detection of circulatory metabolic consequences associated epilepsy. Although previous report revealed that prolonged ictal hyperperfusion on ASL can be firstly detected cortical hyperintensity cytotoxic edema DWI secondarily obtained from an epileptically activated cortex, hemodynamic state has not been fully demonstrated. We retrospectively...
Background: Our recent report showed that 1.5-T pulsed arterial spin labeling (ASL) magnetic resonance (MR) perfusion imaging (1.5-T Pulsed ASL [PASL]), which is widely available in the field of neuroemergency, useful for detecting ictal hyperperfusion. However, visualization intravascular signals, namely, transit artifact (ATA), more remarkable than 3-T pseudocontinuous and easily confused with focal To eliminate ATA enhance detectability (peri) hyperperfusion, we developed subtraction...
Aim: To investigate the discordance in programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors analyze association clinical factors non-small lung cancer (NSCLC) patients. Patients Methods: Twenty-one NSCLC patients who underwent surgery or biopsy for paired lesions at our Institution from 2005 to 2016 were analyzed. Lesions with PD-L1 being ≥5% considered PD-L1-positive. Results: The sites included brain (n=16), adrenal gland (n=3), spleen (n=1) jejunum...
To investigate the association between positivity for programmed cell death-ligand 1 (PD-L1) in brain metastases (BM) and prognosis or clinical factors patients with non-small lung cancer (NSCLC).Thirty-two surgically resected brain-metastatic NSCLC were enrolled. The PD-L1 expression BM was analyzed using antibody against human (clone SP142). defined as on tumor cells of ≥5%.Seven (21.9%) out 32 showed BM. PD-L1-positive group had a significantly shorter brain-specific disease-free survival...
Abstract Objectives To examine the utility of FDG-PET/MRI in patients with epilepsy by comparing diagnostic accuracy PET/MRI and PET/CT epileptogenic zone (EZ) detection. Methods This prospective study included 31 (17 males, 14 females) who underwent surgical resection for EZ. All were first scanned using FDG-PET/CT followed immediately FDG-PET/MRI. Two series PET plus standalone MR images interpreted independently five board-certified radiologists. A 4-point visual score was used to assess...
Magnetic resonance imaging (MRI), including perfusion MRI with three-dimensional pseudocontinuous arterial spin labeling (ASL) and diffusion-weighted (DWI), are applied in the periictal (including ictal postictal) detection of circulatory metabolic consequences associated epilepsy. Our previous report revealed that hyperperfusion can firstly be detected on ASL, cortical hyperintensity cytotoxic edema secondarily obtained DWI from an epileptically activated cortex. Although magnetic...
Targeting the unique glioma immune microenvironment is a promising approach in developing breakthrough immunotherapy treatments. However, recent advances immunotherapy, including development of checkpoint inhibitors, have not improved outcomes patients with glioma. A way monitoring biological activity cells neural tissues affected by should be developed to address this lack sensitivity immunotherapy. Thus, study, we sought examine feasibility non-invasive glioma-associated...
Arterial spin labeling (ASL) imaging with multiple postlabeling delays (PLD) can demonstrate the hemodynamics of peri-ictal hyperperfusion. Labeling methods include pulsed ASL (PASL) and pseudocontinuous (pCASL). Although PASL is more widely used in daily clinical practice, it has several disadvantages because lower delivery labeled magnetization. We compared pCASL images acquired after a 24-h interval, using 1.5-Tesla machine, 62-year-old man non-convulsive status epilepticus. The during...
The hemodynamics of ictal hyperperfusion in dual pathology was evaluated using arterial spin labeling perfusion images (ASL) with triple postlabeling delays (PLDs). A 62-year-old man epileptogenic right parietal hematoma cavity and bilateral hippocampal atrophy, particularly on the right, underwent ASL examination during subtle non-convulsive status epilepticus immediately after focal-to-bilateral tonic-clonic seizures. at PLD 1.5 s showed increased signals gray matter both hemispheres,...
Craniopharyngioma consists of adamantinomatous and papillary subtypes. Recent genetic analysis has demonstrated that the two subtypes are different, not only in clinicopathological features, but also molecular oncogenesis. Papillary craniopharyngioma (pCP) is characterized by a BRAF mutation, V600E (Val 600 Glu) mutation. Adamantinomatous (aCP) can be distinguished frequent β-catenin gene (CTNNB1) mutations. Although these alterations diagnostic marker, precise frequency mutations clinical...
Recent our reports showed that 3-T pseudocontinuous arterial spin labeling (3-T pCASL) magnetic resonance perfusion imaging with dual post delay (PLD) of 1.5 and 2.5 s clearly demonstrated the hemodynamics ictal hyperperfusion associated non-convulsive status epilepticus (NCSE). We aimed to examine utility 1.5-T pulsed (1.5-T PASL), which is more widely available for daily clinical use, detecting hyperperfusion.We retrospectively analyzed findings PASL PLD 2.0 in six patients compared...
Nonconvulsive status epilepticus (NCSE) is generally defined as a change in behavior and/or mental process from the baseline, which associated with ongoing seizure activity or continuous epileptiform discharges on electroencephalography (EEG) absence of convulsive seizures. The present study investigated NCSE incidence using serial EEG during perioperative periods cerebrovascular surgery at medium-sized, local hospital. A total 54 patients were admitted to our department and underwent...
To investigate the radiological features on computed tomography (CT) of brain metastasis (BM) from epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC).Thirty-four patients with NSCLC BMs who underwent surgical resection at Department Neurosurgery, Kyushu University 2005 to 2016 were enrolled in study. The EGFR statuses 34 investigated. Radiological features, including number, size, and location tumor, delineated by CT.Patients EGFR-mutated had significantly...
<b><i>Background:</i></b> An ependyma-lined canal with surrounding neuroglial tissues can be present in lumbosacral lipomatous malformations; however, the precise embryological significance is still unclear. <b><i>Method:</i></b> Six out of 50 patients malformations had ependymal structures. We retrospectively analyzed clinical, neuroradiological, and histological findings these to demonstrate relationship background retained medullary cord...
Recently, brain–computer interfaces, combined with feedback systems and goal-oriented training, have been investigated for their capacity to promote functional recovery after stroke. Accordingly, we developed a interface-triggered robotic hand orthosis that assists hand-closing hand-opening post-stroke patients without sufficient motor output. In this system, near-infrared spectroscopy is used monitor the affected cortex, linear discriminant analysis-based binary classifier estimates...