A5101685685- Estrogen and related hormone effects
- Pluripotent Stem Cells Research
- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Orthopedic Surgery and Rehabilitation
- Axon Guidance and Neuronal Signaling
- Hormonal Regulation and Hypertension
- CRISPR and Genetic Engineering
- Urinary Bladder and Prostate Research
- Angiogenesis and VEGF in Cancer
- Hormonal and reproductive studies
- Pharmacogenetics and Drug Metabolism
- Glycosylation and Glycoproteins Research
- Olfactory and Sensory Function Studies
- RNA Interference and Gene Delivery
- Nitric Oxide and Endothelin Effects
- Laser Applications in Dentistry and Medicine
- Mast cells and histamine
- Tissue Engineering and Regenerative Medicine
- Mass Spectrometry Techniques and Applications
- Chemical Synthesis and Analysis
- Shoulder Injury and Treatment
- Protein Structure and Dynamics
- Urticaria and Related Conditions
- Inflammatory mediators and NSAID effects
Asahi Kasei (Japan)
2025
Sumitomo Dainippon Pharma (Japan)
2013-2024
Hiroshima Institute of Technology
2022-2024
Tottori University Hospital
2022-2023
Ohu University
2013-2023
Kishiwada City Hospital
2022-2023
Keio University
2011-2022
Kyoto University
2013-2021
Sekisui Medical (Japan)
2018
The University of Tokyo
2015-2018
Abstract Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies Parkinson’s disease (PD). The regulatory criteria the clinical application of these therapies, however, have not been established. Here we show results our pre-clinical study, in which evaluate safety and efficacy progenitors (DAPs) derived from a clinical-grade human iPSC line. We confirm characteristics DAPs by vitro analyses. also verify that DAP population...
To report the distinctive clinical features of cryptogenic new-onset refractory status epilepticus (C-NORSE) and C-NORSE score based on initial assessments.A retrospective study was conducted for 136 patients with clinically suspected autoimmune encephalitis who underwent testing autoantibodies to neuronal surface antigens between January 1, 2007, August 31, 2016. Eleven were identified. Their compared those 32 anti-NMDA receptor (NMDARE).The outcome 11 (median age, 27 years; 7 [64%] women)...
Neural stem cells (NSCs) were directly induced from mouse fibroblasts using four reprogramming factors (Oct4, Sox2, Klf4, and cMyc) without the clonal isolation of pluripotent (iPSCs). These NSCs gave rise to both neurons glial even at early passages, while derived embryonic (ESCs)/iPSCs differentiated mainly into neurons. Epidermal growth factor-dependent neurosphere cultivation efficiently propagated these gliogenic eliminated residual that could form teratomas in vivo. We concluded...
Acotiamide hydrochloride (acotiamide; <i>N</i>-[2-[bis(1-methylethyl) amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl) amino] thiazole-4-carboxamide monohydrochloride trihydrate, Z-338) has been reported to improve meal-related symptoms of functional dyspepsia in clinical studies. Here, we examined the gastroprokinetic effects acotiamide and its antiacetylcholinesterase activity as a possible mechanism action conscious dogs. increased postprandial gastric motor dogs with chronically...
Abstract LAIR1 is an inhibitory receptor broadly expressed on human immune cells, including B cells. has been shown to modulate BCR signaling, however, it still unclear whether its suppressive activity can be a negative regulator for autoreactivity. In this study, we demonstrate the expression profile cells and prove regulatory function relationships cell We show that both frequency level of decreases during differentiation. expressing (LAIR1 + ) switched memory (SWM) have transcriptional...
Objectives. HLA-B51 is strongly associated with Behçet's disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) also implicated BD a Japanese population. To confirm these results, we investigated polymorphisms the TLR4 gene Korean patients BD. Methods. In this study, 119 and 141 healthy controls were enrolled; every participant was Korean. Nine single nucleotide previously detected by direct sequencing analysed for an association Results....
<h3>Objective</h3> To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology shares clinicopathologic characteristics IM induced by immune checkpoint inhibitors (ICIs). <h3>Methods</h3> We analyzed the features of 10 patients MG identified in 970 consecutive biopsy-proven IM. <h3>Results</h3> Seven (70%) had thymoma. were diagnosed more than 5-year time difference 6 thymomatous within 1 year...
A long noncoding RNA, nuclear paraspeckle assembly transcript 1 (NEAT1) variant (NEAT1v1), confers radioresistance to hepatocellular carcinoma (HCC) cells by inducing autophagy via γ-aminobutyric acid receptor-associated protein (GABARAP). Radiation induces oxidative stress damage cellular components and organelles, but it remains unclear how NEAT1v1 protects HCC from radiation-induced autophagy. To address this, we precisely investigated NEAT1v1-induced in irradiated cell lines. X-ray...
Background Peripheral nerve damage of the cornea is a complication following surgery or infection which may lead to decreased visual function. We examined efficacy semaphorin 3A inhibitor, SM-345431, in promoting regeneration peripheral nerves mouse corneal transplantation model. Methodology/Principal Findings P0-Cre/Floxed-EGFP mice express EGFP cells were used as recipients with syngeneic wild-type donors. SM-345431 was administered subconjunctivally every 2 days while control received...
Fever is a common response to inflammation and infection. The mechanism involves prostaglandin E2 (PGE2)-EP3 receptor signaling in the hypothalamus, which raises set point of hypothalamic thermostat for body temperature, but lipid metabolic pathway pyretic PGE2 production remains unknown. To reveal molecular basis fever initiation, we examined lipopolysaccharides (LPS)-induced model monoacylglycerol lipase (MGL)-deficient (Mgll−/−) mice, CB1 receptor-MGL compound-deficient (Cnr1−/−Mgll−/−)...
Excess energy intake causes obesity, which leads to insulin resistance and various other complications of metabolic syndrome, including diabetes, atherosclerosis, dyslipidemia, nonalcoholic fatty liver disease. Although recent studies have depicted altered lipid metabolism as an underlying feature, the detailed mechanisms are still unclear. Here we describe a possible role in high-fat diet (HFD)-induced obesity for monoacylglycerol lipase (MGL), enzyme that is also known hydrolyze...
Globular proteins are composed of several modules that contiguous polypeptide segments compact conformation. Module boundaries closely correlated with the intron positions genes encode proteins. The may thus have a one-to-one correspondence exons in primordial genes. They also be vestiges initially appeared as prebiological evolution. Clarification to whether disconnected from one another functional potentiality validate these possibilities. Thus, this study, each module protein was...
A compact cavity ring-down spectrometer aimed at the detection of trace amounts radiocarbon (14C) in biomedical samples is demonstrated. Rapid sampling, as required for large scale studies, made possible by modifications to a CHNS elemental analyzer. After conversion carbon content sample into CO2, spectral analysis using high-finesse conjunction with quantum cascade laser system reveals ratio 14CO2 relation stable isotopologues 12C and 13C. Cooling temperature stabilization achieved...
Pluripotent stem cell (PSC)-derived dopaminergic (DA) neurons are an expected source of therapy for Parkinson's disease. The transplantation aggregates or neurospheres, instead a single suspension has several advantages, such as keeping the 3D structure donor cells and ease handling. For this PSC-based to become widely available treatment, cryopreservation final product is critical in manufacturing process. However, cryopreserving more complicated than suspensions. Previous studies showed...
Interethnic differences in genetic polymorphism genes encoding drug-metabolizing enzymes and transporters are one of the major factors that cause ethnic drug response. This study aimed to investigate polymorphisms involved metabolism, transport, excretion among Korean, Japanese, Chinese populations, three East Asian groups.The frequencies 1936 variants representing 225 were determined from 786 healthy participants (448 208 130 Chinese) using Affymetrix Drug-Metabolizing Enzymes Transporters...
Semaphorin family members have been identified as axonal guidance molecules that mediate the directional determination for elongation during neuronal development. Several semaphorins shown to play crucial roles various immune response phases. In a previous study using knockout mice, we suggested Plexin-A1, 3A (Sema3A) receptor, is involved in increased production of inflammatory factors such interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) murine microglial lipopolysaccharide...
Recent investigations have suggested that semaphorins, which are known repulsive axon guidance molecules, may play a crucial role in maintaining brain homeostasis by regulating microglial activity. Sema3A, secreted higher amounts from injured neurons, is considered to suppress excessive inflammatory responses inducing apoptosis through its binding Plexin-A1 receptors on activated microglia. To clarify the vivo of Plexin-A1-mediated signaling lipopolysaccharide (LPS)-induced injury mouse...