A5069390177- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Pluripotent Stem Cells Research
- Medical Imaging and Pathology Studies
- DNA Repair Mechanisms
- Bioactive Compounds in Plants
- CRISPR and Genetic Engineering
- Microbial Natural Products and Biosynthesis
- Cell death mechanisms and regulation
- Phytochemicals and Antioxidant Activities
- Geriatric Care and Nursing Homes
- Single-cell and spatial transcriptomics
- Mobile Health and mHealth Applications
- Cancer-related Molecular Pathways
- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Marine Sponges and Natural Products
- Law and Political Science
- Venous Thromboembolism Diagnosis and Management
- Identification and Quantification in Food
- Antimicrobial Resistance in Staphylococcus
- Cancer Research and Treatments
- Bioactive natural compounds
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pomegranate: compositions and health benefits
Kyoto University
2016-2025
Kanazawa University
2024-2025
Kyushu University
2024
Sumitomo Dainippon Pharma (Japan)
2024
Juntendo University
2000-2023
Showa University
2021-2022
Hiroshima University
1998-2019
Juntendo University Urayasu Hospital
2019
Chiba Prefectural Institute of Public Health
2015-2018
Moores Cancer Center
2016-2017
Abstract Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies Parkinson’s disease (PD). The regulatory criteria the clinical application of these therapies, however, have not been established. Here we show results our pre-clinical study, in which evaluate safety and efficacy progenitors (DAPs) derived from a clinical-grade human iPSC line. We confirm characteristics DAPs by vitro analyses. also verify that DAP population...
Abstract Purpose: Genomic alterations in blood-derived circulating tumor DNA (ctDNA) from patients with non–small cell lung adenocarcinoma (NSCLC) were ascertained and correlated clinical characteristics therapeutic outcomes. Experimental Design: Comprehensive plasma ctDNA testing was performed 88 consecutive patients; 34 also had tissue next-generation sequencing; 29, other forms of genotyping; 25 (28.4%) no molecular tests because inadequate or biopsy contraindications. Results:...
Abstract Purpose: There is a growing interest in using circulating tumor DNA (ctDNA) testing patients with cancer. Experimental Design: A total of 168 diverse cancers were analyzed. Patients had digital next-generation sequencing (54 cancer-related gene panel including amplifications ERBB2, EGFR, and MET) performed on their plasma. Type genomic alterations, potential actionability, concordance tissue testing, patient outcome examined. Results: Fifty-eight percent (98/168) ≥1 ctDNA...
ABSTRACT We identified a novel type of staphylococcal cassette chromosome mec (SCC ) element carried by methicillin-resistant Staphylococcus aureus (MRSA) strain JCSC6082 isolated in Sweden. The SCC was demarcated characteristic nucleotide sequences at both ends and integrated the 3′ end orfX . combination 5 ccr gene complex class C1 complex. J regions were homologous to those mercury S. 85/2082, with identity greater than 99%. However, from did not carry mer operon nor Tn 554 , suggesting...
Background: Stroke or traumatic brain injury (TBI), due to damage the cerebral motor cortex, often results in significant dysfunction and disabilities. Cell replacement therapy emerges as a prospective alternative treatment, promising restore impaired neural circuits facilitate functional recovery. The current study aimed systemically identify new factors capable of enhancing efficacy cell transplantation with human-induced pluripotent stem cell-derived organoids (hiPSC-COs). Earlier...
<title>Abstract</title> Background <italic>Clostridioides difficile</italic> infection (CDI) is a gastrointestinal condition that arises from the disruption of normal intestinal flora, often caused by antibiotics or antiacids. Fulminant CDI, characterized shock, obstruction, and toxic megacolon, has poor prognosis. Patients with chronic kidney disease (CKD) those on maintenance hemodialysis are at higher risk for developing experiencing severe progression, facing increased mortality. Case...
Nobiletin is a citrus polymethoxyflavonoid that suppresses tumor growth and metastasis, both of which depend on angiogenesis. We recently identified nobiletin as cell differentiation modulator. Because critical event in angiogenesis, it might be possible could exhibit antiangiogenic activity, resulting suppression these malignant properties. To verify this possibility, we examined the effects vitro vivo . had concentration‐dependent inhibitory multiple functions angiogenesis‐related...
Organoids, self-organized cell aggregates, contribute significantly to developing disease models and cell-based therapies. Organoid-to-organoid variations, however, are inevitable despite the use of latest differentiation protocols. Here, we focused on morphology organoids formed in a cerebral organoid culture assessed their cellular compositions by single-cell RNA sequencing analysis. The data revealed that primarily composed non-neuronal cells, such as those from neural crest choroid...
Jomthonic acid A (1), a new modified amino acid, was isolated from the culture broth of soil-derived actinomycete genus Streptomyces. The structure and absolute configuration 1 were determined by spectroscopic analyses chemical conversion. (1) induced differentiation preadipocytes into mature adipocytes at 2–50 μM.
An acid phosphatase has been purified from the culture broth of Penicillium funiculosum by procedures including SP-Sephadex column chromatography and Sephacryl S-200 gel filtration. The appears to be a 76 kDa heterodimer composed 51 26 subunits on sodium dodecyl sulfate-polyacrylamide electrophoresis. enzyme hydrolyzes both phosphodiesters phosphomonoesters, but only those with aryl leaving groups. At early phase degradation bis-p-nitrophenyl phosphate enzyme, inorganic intermediary product,...
Adiponectin, an adipose-derived protein, shows insulin-sensitizing, anti-diabetic and anti-atherogenic activities, which implies that the protein represents a potential target to improve lifestyle-related diseases like type 2 diabetes. Based on our hypothesis agents cause adipocyte differentiation could also act as adiponectin secretion enhancers, we screened butanol extracts of 96 fungus culture for their differentiation-inducing activity in ST-13 preadipocytes. We found extract P16...
Abstract Tumor development in the skin may be a multistep process where multiple genetic alterations occur successively. The p53 gene is involved genome stability and thus referred to as “the guardian of genome.” To better understand antigenotoxic effects ultraviolet light B (UVB)‐induced mutagenesis, mutations were measured epidermis UVB‐irradiated +/+ −/− gpt delta mice. In mouse model, point deletions are separately identified by Spi − assays, respectively. mice exposed UVB at single...
One major concern over the clinical application of embryonic stem cell (ESC)-derived cells is potentiation latent tumorigenicity by residual undifferentiated cells. Despite use intensive methodological approaches to eliminate cells, properties these remain elusive. Here, we show that under a serum-free neural differentiation condition, markedly delay progression their cycle without compromising pluripotency. This dormant pluripotency was maintained during reculture whereas upon serum...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, structure, and acetolysis of some fused cyclobutane derivativesR. L. Petty, M. Ikeda, G. E. Samuelson, C. J. Boriack, K. D. Onan, A. T. McPhail, MeinwaldCite this: Am. Chem. Soc. 1978, 100, 8, 2464–2474Publication Date (Print):April 1, 1978Publication History Published online1 May 2002Published inissue 1 April 1978https://pubs.acs.org/doi/10.1021/ja00476a033https://doi.org/10.1021/ja00476a033research-articleACS PublicationsRequest reuse...
According to a good correlation between in situ hybridization-based metalloproteinase-2/9:E-cadherin ratio (MER) and the pathological stage of prostate cancer, we set cutoff line MER at 6.0 (MER<sup>></sup><sup>6</sup>) distinguish organ-confined (pT2) advanced diseases (pT3a-b/N1). In this study, looked factors affecting leading misprediction stage. We examined 39 paired specimens core needle biopsy prostatectomy from same patient compared these MERs. 34 (87%)...
The potential of interactive health application software (app) for the management chronic illness is becoming recognized. We developed iPad (Apple) app that conducts COPD-specific self-management education in 2014 (Am J Respir Crit Care Med 191; 2015:A1112). To assess efficacy iPad-based intervention improving status patients with moderate to very severe COPD compared usual care, a single-center RCT was started from June 2014. In addition 40 educational contents, by default program...