A5101601239- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- Glutathione Transferases and Polymorphisms
- Effects and risks of endocrine disrupting chemicals
- Cardiac Imaging and Diagnostics
- Antioxidant Activity and Oxidative Stress
- Microbial infections and disease research
- Peroxisome Proliferator-Activated Receptors
- Herpesvirus Infections and Treatments
- Toxic Organic Pollutants Impact
- Drug Transport and Resistance Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Pharmacogenetics and Drug Metabolism
- Folate and B Vitamins Research
- Acute Myocardial Infarction Research
- Trace Elements in Health
- Veterinary Oncology Research
- Heavy Metal Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Animal Virus Infections Studies
- Sulfur Compounds in Biology
- Virus-based gene therapy research
- Mycotoxins in Agriculture and Food
- Potato Plant Research
Yamazaki College of Animal Health Technology
2018-2025
National Institute of Health Sciences
2015-2024
Mongolian University of Life Sciences
2017-2020
Japan International Cooperation Agency
2020
National Institute of Health Sciences
2005-2018
Yamazaki University of Animal Health Technology
2017-2018
Hiroshima University
2005-2017
Gifu University
2014
Hokkaido University
2003-2012
University Hospital Bonn
2011
The purpose of this study was to evaluate endothelial function in patients with periodontitis. We evaluated forearm blood flow responses acetylcholine and sodium nitroprusside periodontitis who had no other cardiovascular risk factors (32 men; 25+/-3 years age), a normal control group (20 26+/-3 hypertensive (28 men 10 women; 56+/-12 age) without (control group; 18 6 54+/-13 age). Forearm measured using strain-gauge plethysmography. Circulating levels C-reactive protein interleukin-6 were...
Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number circulating EPCs might reflect pathogenesis atherosclerosis and progression cardiovascular diseases (CVDs). purpose this study was to evaluate relationship between risk factors.Flow cytometry analysis used quantify (CD34(+)AC133(+)CD45(low)) in 135 consecutive hospitalized patients with CVD 25 healthy subjects.The less than subjects (1,047.4 +/- 521.1 vs. 612.8 461.6/ml, P <...
8-Hydroxydeoxyguanosine (8-OH-dG) levels were examined in liver and kidney DNA after di(2-ethylhexyl)phthalate (DEHP), di(2-ethylhexyl)adipate (DEHA) phthalic anhydride administration to male 6-week-old F-344 rats the diet at concentrations of 1.2, 2.5 1.5%, respectively. Significant increases 8-OH-dG observed only (target organ DEHP DEHA carcinogenesis) 1 2 weeks treatment with DEHA, The results suggest involvement oxidative damage hepatocarcinogenesis by peroxisome proliferators.
Summary A condition showing anaemia with asplasia of the bone manrow and atrophy lymphoid organs occurred in young layer chickens on a poultry farm. An agent (tentatively designated TK‐5803 strain) was isolated specific‐pathogen‐free (SPF) chicks from livers field cases. The severely pathogenic when inoculated into 1‐day‐old SPF chicks, but developed age resistance to agent. produced no cytopathic effect nor alterations chick embryo fibroblasts kidney cells. Antisera had neutralising...
Ochratoxin A (OTA) can induce renal tumors that originate from the S3 segment of proximal tubules in rodents, but results conventional mutagenicity tests have caused controversy regarding role genotoxic mechanisms carcinogenesis. Human exposure to OTA various foods is unavoidable. Therefore, an understanding OTA-induced carcinogenesis necessary for accurate estimates human risk hazard. In present study, a 13-week gpt delta rats at carcinogenic dose induced karyomegaly and apoptosis outer...
The roles of glutathione (GSH), cysteine, vitamin C., liposome‐encapsulated superoxide dismutase (L‐SOD) and E in preventing oxidative DNA damage cytotoxicity the rat kidney after administration potassium bromate (KBrO 3 ) to male F344 rats were investigated by measuring 8‐hydroxydeoxyguanosine (8‐OH‐dG), an product, lipid peroxidation (LPO) levels relative weight (RKW). Combined pre‐ posttreatment animals with 2 × 800 mg/kg GSH i.p. inhibited increase 8‐OH‐dG, LPO RKW caused 80 KBrO...
Our goal was to elucidate roles of Nrf2 in vivo defense against pentachlorophenol (PCP), an environmental pollutant and hepatocarcinogen mice. We examined oxidative stress cell proliferation, along with other hepatotoxicological parameters, the livers nrf2-deficient (wild:+/+, heterozygous:+/−, homozygous:−/−) animals fed PCP their diet at doses 0, 150, 300, 600, or 1200 ppm for 4 weeks. For measurement methoxyresorufin-O-demethylase (CYP 1A2), NAD(P):quinone oxidoreductase 1 (NQO1),...
Changes in kidney levels of 8‐hydroxydeoxyguanosine (8‐OH‐dG), lipid peroxidation (LPO), glutathione (GSH) and relative organ weight were examined 6, 24, 48, 72 96 h after a single i.p. administration potassium bromate (KBrO 3 ) at dose 70 mg/kg to male F344 rats. The 8‐OH‐dG level was significantly increased 24 the treatment this thereafter gradually decreased. On other hand, significant elevation LPO observed from 6 with continuous increase up plateau 48 no subsequent drop. GSH raised h,...
One-day-old chicks, inoculated intramuscularly with the MSB1-TK5803 strain of chicken anaemia agent (CAA), showed a decrease haematocrit value and inhibition body weight gain, particularly between days 12 20 post inoculation (pi). Macroscopically, yellowish bone marrow, atrophy thymus bursa Fabricius, enlargement discoloration liver were observed in most chicks at peak infection. Histologically, lesions appeared first marrow on day 6 pi, then bursa, spleen liver. Swelling intranuclear...
To elucidate the roles of transcription factor NF‐E2‐related (Nrf2) in hepatocarcinogenesis induced by 2‐amino‐3‐methylimidazo[4,5‐ f ]quinoline (IQ), a mutagenic and carcinogenic heterocyclic amine, Nrf2‐deficient mice were treated with 300 p.p.m. IQ their diet for 1, 4 or 52 weeks. In long‐term experiment, multiplicity incidence liver tumors male female IQ‐treated Nrf2 deficient (–/–) significantly higher than those counterpart wild‐type (+/+) exposed to IQ. short‐term although exposure...
The TK-5803 strain of an agent which induces chicken anaemia was propagated and titrated in cultures the MDCC-MSB1 cell line. When isolates (tentatively designated MSBI-TK-5803 strain) from original material were inoculated into 1-day-old susceptible chicks, they showed a severe pathogenicity, inducing with aplasia bone marrow atrophy lymphoid organs. On density gradient separation, peak their infectivity titre appeared at 1.35 to 1.36 g/cm(3) numerous virus particles demonstrated same...
Ochratoxin A (OTA) is a renal carcinogen primarily affecting the S3 segment of proximal tubules in rodents. In our previous study, we reported that OTA induces reporter gene mutations, deletion outer medulla (OM), specifically segment. present to identify genes involved OTA-induced genotoxicity, conducted comparative analysis global expression cortex (COR) and OM kidneys from gpt delta rats administered at carcinogenic dose for 4 weeks. Genes associated with DNA damage repair, cell cycle...