A5046783529- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Barrier Structure and Function Studies
- Genetic factors in colorectal cancer
- Digestive system and related health
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Pancreatic and Hepatic Oncology Research
- Prostate Cancer Treatment and Research
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Telomeres, Telomerase, and Senescence
- Fatty Acid Research and Health
- Cancer Cells and Metastasis
- Peroxisome Proliferator-Activated Receptors
- Bladder and Urothelial Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Neurological Disease Mechanisms and Treatments
- Helicobacter pylori-related gastroenterology studies
Nara Medical University
2016-2025
Nara Medical University Hospital
2005-2019
Fukuoka University
2013-2015
National Institute of Infectious Diseases
2014
National Institute of Health Sciences
2014
National Institutes of Health
2014
Osaka University
2014
Ajinomoto (Japan)
2013
Suzuki (Japan)
2013
Ajinomoto (United States)
2013
Background: By the time patients are diagnosed with ovarian carcinoma, peritoneal dissemination of tumor often has occurred. The progressive growth and spread carcinoma depend, in part, on formation an adequate blood supply. We determined whether expression genes that regulate distinct steps angiogenesis (i.e., new vessels) was associated pattern human carcinomas implanted cavity nude mice. Methods: Five different were injected individually into female NCr-nu/nu basic fibroblast factor,...
We determined whether the implantation of human pancreatic cancer cells into pancreas nude mice can be used to select variants with increasing metastatic potential. COLO 357 line fast-growing were injected spleen or mice. Hepatic metastases harvested, and tumor reinjected pancreas. This cycle was repeated several times yield cell lines L3.6sl (spleen liver) L3.6pl (pancreas liver). The variant produced significantly higher incidence number lymph node liver than parental cells. Their...
The receptor for advanced glycation end-products (RAGE) is a newly recognized factor regulating cancer cell invasion and metastasis. This study investigated the expression of RAGE in gastric carcinomas its association with Of eight lines examined, seven constitutively expressed messenger ribonucleic acid (mRNA), MKN45 being exception. protein MKN28 cells treated antisense S-oligodeoxynucleotide was nine times less than that sense S-oligodeoxynucleotide-treated cells. Growth under treatment...
MicroRNA (miRNA)-126 (miR-126) is an endothelial-specific miRNA located within intron 7 of epidermal growth factor-like domain (EGFL7). However, the role miR-126 in cancer controversial.We examined function oral squamous cell carcinoma (OSCC) cells. Furthermore, a series 118 cases with OSCC were evaluated for expression levels miR-126.MicroRNA-126 was associated and regulation vascular endothelial factor-A activity, demethylation treatment increased EGFL7 A significant association found...
Abstract Cancer cells produce energy through aerobic glycolysis, but contributions of host tissues to cancer metabolism are unclear. In this study, we aimed elucidate the cancer–host production relationship, in particular, between and muscle. During development progression colorectal cancer, expression secreted autophagy-inducing stress protein HMGB1 increased muscle tumor-bearing animals. This effect was associated with decreased pyruvate kinase PKM1 activity via receptor for advanced...
Anticancer agents are playing an increasing role in the treatment of gastric cancer (GC); however, novel anticancer have not been fully developed. Therefore, it is important to investigate compounds that improve sensitivity existing drugs. We reported pterostilbene (PTE), a plant stilbene, enhances antitumor effect low doses sunitinib cells accumulating mitochondrial iron (II) (mtFe) at doses. In this study, we investigated relationship between mtFe deposition and synergistic PTE different...
While 5-fluorouracil (5FU) plays a central role in chemotherapy for colorectal cancer (CRC), resistance to 5FU remains major challenge CRC treatment, and its underlying mechanisms remain unclear. In this study, we investigated the relationship between acquisition, stemness, energy metabolism. Among two cell lines, HT29 cells exhibited glycolytic quiescent properties, while CT26 relied on oxidative phosphorylation (OXPHOS) energy. contrast, 5FU-resistant sublines (HT29R CT26R), developed...
We searched for genetic alterations of the cyclin D1 and E genes in 45 human gastric carcinoma tissues. Expression mRNA protein was also analyzed eight them by Northern Western blots immunohistochemical staining. The gene amplified 3-10 fold seven cancer tissues (15.6%), which six were advanced cancers. All cases with amplification displayed lymph node metastasis. Moreover, case overexpressed protein. One cell lines, MKN-7, shared amplification, all lines expressed high levels even without...
Abstract BACKGROUND The authors purpose in this study was to clarify the difference terms of clinicopathologic features between gastric cancer (GC) with high numbers DNA methylated genes and CpG island methylator phenotype (CIMP)‐positive GC as originally defined. METHODS We analyzed methylation 12 tumor‐related ( hMLH1 , MGMT p16 INK4a CDH1 RAR ‐ beta HLTF RIZ1 TM FLNc LOX HRASLS HAND1 ) 75 samples from patients, 25 corresponding nonneoplastic mucosa 10 normal healthy young individuals by...
Abstract Heme oxygenase (HO)‐1 is a key player reducing cytotoxicity and enhancing protumoral effects of nitric oxide (NO). We examined zinc protoporphyrin (ZnPP) IX, an HO‐1 inhibitor, to affect tumor growth LL/2 mouse lung cancer cells. ZnPPIX reduced expression HO activity in cells, whereas cobalt PPIX (CoPPIX), activator, increased both. cells treated with sodium nitropurusside, NO donor, showed inhibition dose‐dependently, which was enhanced by cotreatment, but CoPPIX. In mice tumors,...
Abstract Amphoterin is 1 ligand of the receptor for advanced glycation end products (RAGE). We studied expression amphoterin and RAGE mRNA proteins in colorectal carcinoma cells investigated their associations with invasive activities exposed to (AGE). Expression was examined 4 cell lines. All lines expressed both amphoterin. The effects on growth (MTT assay), migration (wound healing assay) invasion ( vitro were tested by treatment antisense S‐oligodeoxynucleotides (ODNs). Cell growth,...
// Mariko Obayashi 1, * , Maki Yoshida 9, Takaaki Tsunematsu 2 Ikuko Ogawa 3 Tomonori Sasahira 4 Hiroki Kuniyasu Issei Imoto 5 Yoshimitsu Abiko 6 Dan Xu 7, 8 Saori Fukunaga 7 Hidetoshi Tahara Yasusei Kudo Toshitaka Nagao 9 Takashi Takata 1 Department of Oral and Maxillofacial Pathobiology, Institute Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan Molecular Pathology, Biosciences, The University Tokushima Graduate School, Tokushima, Center Clinical Examination, Hospital,...
The brainstem is a posterior region of the brain, composed three parts, midbrain, pons, and medulla oblongata. It critical in controlling heartbeat, blood pressure, respiration, all which are life-sustaining functions, therefore, damages to or disorders can be lethal. Brain organoids derived from human pluripotent stem cells (hPSCs) recapitulate course brain development expected useful for medical research on central nervous system disorders. However, existing organoid models limited extent...