Shunsuke Nishimura
A5084951436- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Diamond and Carbon-based Materials Research
- Pericarditis and Cardiac Tamponade
- Medical Imaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Viral Infections and Immunology Research
- Radiomics and Machine Learning in Medical Imaging
- Geotechnical Engineering and Underground Structures
- Cardiac Structural Anomalies and Repair
- Semiconductor materials and interfaces
- Glioma Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Advanced MRI Techniques and Applications
- Cardiac tumors and thrombi
- Heat shock proteins research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Brain Metastases and Treatment
Kyushu University
2023-2025
Osaka University
2020-2025
The University of Tokyo
2023
JGC (Japan)
2023
Nagoya University
2022
Tenri Hospital
2013-2020
Kyoto University
2017
Nomura Research Institute
2016
Osaka City University
2013
Saitama Medical University
2005
Aim: Severe gastrointestinal bleeding sometimes occurs in patients with aortic stenosis (AS), known as Heyde's syndrome. This syndrome is thought to be caused by acquired von Willebrand and characterized reduced large factor (vWF) multimers. However, the relationship between severity of AS loss vWF multimers unclear.Methods: We examined 31 consecutive severe AS. Quantitative evaluation for was performed using conventional ratio novel multimer index. index defined those controls.Results: Loss...
Previous studies have reported that insulin resistance plays an important role in the progression of atherosclerosis. However, relationship between and coronary plaque instability is not well established. The purpose this study was to assess characteristics identified by optical coherence tomography (OCT).This enrolled 155 consecutive patients undergoing percutaneous intervention. OCT image acquisitions were performed culprit lesions. Insulin using homeostasis model assessment (HOMA-IR)....
Cardiac-specific myosin light chain kinase (cMLCK), encoded by
Dynamic nuclear polarization (DNP) using the boron vacancy ($\mathrm{V_B^-}$) in hexagonal nitride (hBN) has gained increasing attention. Understanding this DNP requires systematically investigating optically detected magnetic resonance (ODMR) spectra and developing a model that quantitatively describes its behavior. Here, we measure ODMR of $\mathrm{V_B^-}$ $\mathrm{h}^{10}\mathrm{B}^{15}\mathrm{N}$ over wide field range, including ground state level anti-crossing (GSLAC), compare them with...
Dilated cardiomyopathy (DCM) is a major cause of heart failure, characterized by ventricular dilatation and systolic dysfunction. Familial DCM reportedly caused mutations in more than 50 genes, requiring precise disease stratification based on genetic information. However, the underlying causes 60 to 80% familial cases remain unknown. Here, we identified that homozygous truncating gene encoding Bcl-2–associated athanogene (BAG) co-chaperone 5 (BAG5) inherited five patients among four...
The optimal timing of aortic valve replacement (AVR) is controversial in patients with asymptomatic severe stenosis (AS) except when very severe. Prediction progression AS helpful deciding on the AVR. purpose this study was to clarify predictors rate and clinical outcomes AS.We retrospectively investigated 140 consecutive (aortic area [AVA], 0.75-1.0 cm(2)). First-year annual AVA jet velocity (AV-Vel) were calculated. Cardiac events examined rapid cardiac analyzed. median follow-up period 36...
Background:Constrictive pericarditis (CP) is characterized by impaired diastolic cardiac function leading to heart failure. Pericardiectomy considered effective treatment for CP, but data on long-term clinical outcomes after pericardiectomy are limited.
Abstract Prognostic impact of anemia complicating severe aortic stenosis (AS) remains unclear. We assessed the on cardiovascular and bleeding outcomes in 3403 patients enrolled CURRENT AS registry. 835 (25%) had mild (hemoglobin 11.0–12.9 g/dl for men/11.0–11.9 women) 1282 (38%) moderate/severe (Hb ≤ 10.9 g/dl) at diagnosis AS. Mild were associated with significantly increased risks relative to no ≥13.0 men/≥12.0 primary outcome measure (aortic valve-related death or heart failure...
HNCM tends to have more diffuse or generalized hypertrophy than HOCM, although these two types are not fundamentally different in aetiology (genetic). Extreme ASH is primarily related a hereditary factor while HNCM, including apical hypertrophy, seems be based on an abnormal disposition produce myocardial response endogenous exogenous stimulation such as catecholamines, chronic anoxia, hypertension even aging. Hypertension by itself, however, can cause of hypertrophy. The configuration left...
A 60-year-old man was admitted due to the onset of right coronary artery (RCA) aneurysms. Coronary angiography showed two RCA aneurysms and focal stenosis with limitations in blood flow. Balloon angioplasty performed. However, follow-up restenosis, an enlarged proximal aneurysm a newly formed aneurysm. The serum immunoglobulin G4 level elevated 1,350 mg/dL fluorodeoxyglucose positron emission tomography increased uptake ascending aorta, so patient diagnosed G4-related vascular disease....
Tricuspid regurgitation (TR) has been reported to be associated with worse survival in various heart diseases, but there are few data aortic stenosis (AS). In the Contemporary Outcomes after Surgery and Medical Treatment Patients Severe Aortic Stenosis (CURRENT AS) Registry enrolling 3815 consecutive patients severe AS, were 628 moderate or TR (TR group) 3187 no mild (no group). The study subdivided into initial valve replacement (AVR) stratum (n = 1197) conservative 2618) according...
Various techniques have been applied to visualize superconducting vortices, providing clues their electromagnetic response. Here, we present a wide-field, quantitative imaging of the stray field vortices in thin film using perfectly aligned diamond quantum sensors. Our analysis, which mitigates influence sensor inhomogeneities, visualizes magnetic flux single YBa2Cu3O7−δ with an accuracy ±10%. The obtained vortex shape is consistent theoretical model, and penetration depth its temperature...
Background Data are scarce on the role of aortic valve area (AVA) to identify those patients with asymptomatic severe stenosis (AS) who at high risk adverse events. We sought explore prognostic impact AVA in AS a large observational database. Methods and Results Among 3815 consecutive enrolled CURRENT (Contemporary Outcomes After Surgery Medical Treatment Patients With Severe Aortic Stenosis) registry, present study included 1309 conservatively managed left ventricular ejection fraction...
Quantum diamond microscopy (QDM), which employs nitrogen-vacancy (NV) center ensembles, is a promising approach to quantitatively imaging magnetic fields with both high resolution that approaches the diffraction limit and wide field of view. The commonly adopted setups QDM capture photoluminescence through transparent diamonds, inevitably entail aberrations -- optical errors degrade contrast obtainable image. In this study, we delve into impact aberrations, focusing on their dependence...
There are limited data regarding the risk stratification based on peak aortic jet velocity (Vmax) in patients with severe stenosis (AS).Among 3815 consecutive AS enrolled CURRENT (Contemporary Outcomes After Surgery and Medical Treatment Patients With Severe Aortic Stenosis) registry, study population consisted of 1075 conservatively managed Vmax ≥4.0 m/s left ventricular ejection fraction ≥50%. The were subdivided into 3 groups (group 1, 4.0 ≤ <4.5 m/s, N=550; group 2, 4.5 <5 N=279; 3, ≥5...
There is no large-scale study comparing postoperative mortality after aortic valve replacement (AVR) for asymptomatic severe stenosis (AS) between initial treatment with AVR vs. eventual conservative management. Methods and Results: We analyzed data from a multicenter registry enrolling 3,815 consecutive patients AS. Of 1,808 patients, 286 initially underwent (initial group), 377 were managed conservatively eventually (AVR watchful waiting group). Mortality was compared the 2 groups....