Yutaka Furukawa
A5058916312- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Cardiac Arrhythmias and Treatments
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Mechanical Circulatory Support Devices
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrest and Resuscitation
- Myasthenia Gravis and Thymoma
- Cardiac Health and Mental Health
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
Kobe City Medical Center General Hospital
2016-2025
Kyoto University
2009-2024
Akita University Hospital
2019-2024
Kansai Electric Power Hospital
2024
Chiba University Hospital
2019-2023
National Cerebral and Cardiovascular Center
2022
Kanazawa University
1991-2022
National Hospital Organization
2011-2022
Kanazawa Medical Center
2022
Ishikawa Prefectural Nursing University
2022
<h3>Importance</h3> Very short mandatory dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with a drug-eluting stent may be an attractive option. <h3>Objective</h3> To test the hypothesis of noninferiority 1 month DAPT compared standard 12 months for composite end point cardiovascular and bleeding events. <h3>Design, Setting, Participants</h3> Multicenter, open-label, randomized clinical trial enrolling 3045 patients who underwent PCI at 90 hospitals in Japan...
Background —Unstable atherosclerotic plaques that cause acute coronary events usually contain abundant macrophages expressing matrix metalloproteinases (MMPs) and tissue factor (TF), molecules probably contribute to plaque rupture subsequent thrombus formation. Lipid lowering with HMG-CoA reductase inhibitors reduces events. Methods Results —To test whether lipid an inhibitor retards macrophage accumulation in rabbit atheroma, we administered cerivastatin immature Watanabe heritable...
A large transmural myocardial infarction may initiate structural and geometric changes in the left ventricle that are commonly referred to as remodeling. Progressive, adverse remodeling of myocardium lead ventricular dilatation congestive heart failure. Recent studies have highlighted effects some cytokines on immune-mediated myocyte injury, postischemic inflammation, cardiac function. However, involvement few.In a rat model infarction, progressive cavity lack appropriate hypertrophy...
<h3>Importance</h3> Clopidogrel monotherapy after short dual antiplatelet therapy (DAPT) percutaneous coronary intervention (PCI) has not yet been fully investigated in patients with acute syndrome (ACS). <h3>Objective</h3> To test the hypothesis of noninferiority 1 to 2 months DAPT compared 12 for a composite end point cardiovascular and bleeding events ACS. <h3>Design, Setting, Participants</h3> This multicenter, open-label, randomized clinical trial enrolled 4169 ACS who underwent...
Prediction of thrombotic and bleeding risk is important to optimize antithrombotic therapy after percutaneous coronary intervention.We developed the prediction rules for events separately in Japanese patients. Derivation validation cohorts consisted 4778 patients from CREDO-Kyoto (Coronary Revascularization Demonstrating Outcome Study Kyoto) registry cohort 2 4669 RESET (Randomized Evaluation Sirolimus-Eluting Versus Everolimus-Eluting Stent Trial) NEXT (Nobori Biolimus-Eluting Xience/Promus...
PAD peripheral arterial disease PCI percutaneous coronary intervention peak V ˙O2 oxygen uptake PH pulmonary hypertension PVCs premature ventricular contraction QOL quality of life RCT randomized controlled trial RPE rating perceived exertion SGA Subjective Global Assessment STEMI ST elevation myocardial infarction TG triglyceride TAVI transcatheter aortic valve implantation VAD assist device ˙CO2 carbon dioxide output ˙E minute ventilation ˙E/V ventilatory equivalent for vs. slope ˙O2/HR...
Background: Despite recommendations in the guidelines and consensus documents, there has been no randomized controlled trial evaluating oral anticoagulation (OAC) alone without antiplatelet therapy (APT) patients with atrial fibrillation stable coronary artery disease beyond 1 year after stenting. Methods: This study was a prospective, multicenter, open-label, noninferiority comparing OAC to combined single APT among stenting 1:1 randomization fashion. The primary end point composite of...
Background Hepatocyte growth factor (HGF) is a multifunctional implicated in tissue regeneration, wound healing, and angiogenesis. Circulating HGF reportedly elevated during the early stage of myocardial infarction. However, its precise effect on heart unknown. To evaluate regulation ischemically damaged myocardium, production high-affinity receptor, c-Met, was studied rat model ischemia reperfusion. Methods Results The plasma concentration began to increase within 1 hour reperfusion after...
<b>Objective</b> To evaluate the relation of symptom onset to balloon time and door with long term clinical outcome in patients ST segment elevation myocardial infarction (STEMI) having primary percutaneous coronary intervention. <b>Design</b> Observation large cohort acute infarction. <b>Setting</b> 26 tertiary hospitals Japan. <b>Participants</b> 3391 STEMI who had intervention within 24 hours onset. <b>Main measures</b> Composite death congestive heart failure, compared by time....
The management of aortic intramural hematoma (IMH) involving the ascending aorta (type A) has not been well-established. purpose this study was to clarify long-term clinical outcomes patients with type A IMH who were treated medical therapy and timely operation.Clinical data including operative mortality, IMH-related events, survival retrospectively reviewed in 66 IMH, admitted our institution from 1986 2006. Emergent surgical repair performed 16 (24%) because severe complications, whereas...
Recently, the Academic Research Consortium for High Bleeding Risk (ARC-HBR) has been proposed to standardize definition of HBR, which was arbitrarily defined as a 3 or 5 bleeding ≥4% at 1-year. However, prevalence and expected event rate HBR patients by ARC-HBR criteria are currently unknown in real-world percutaneous coronary intervention practice.We applied CREDO-Kyoto (Coronary Revascularization Demonstrating Outcome Study Kyoto) registry cohort-2, multicenter that enrolled 13 058...
Background: There is a scarcity of reports on the clinical characteristics and management practice in contemporary all-comer patients with acute decompensated heart failure (ADHF).
Abstract The high controlling nutritional status (CONUT) score that represents poor has been acknowledged to have prognostic implications in chronic heart failure. We aimed investigate its role acute decompensated failure (ADHF). Using the data from an multicenter registry enrolled 4056 consecutive patients hospitalized for ADHF Japan between 2014 and 2016, we analyzed 2466 whom on components of CONUT at hospital presentation were available. decrease lymphocyte count total cholesterol was...
We have identified and characterized mouse, rat, human cDNAs that encode a novel secreted protein of 448 amino acids named DANCE (developmental arteries andneural crest epidermal growth factor (EGF)-like). contains six calcium-binding EGF-like domains, one which includes an RGD motif. Overexpression studies recombinant document is 66-kDa protein. recently described S1–5 comprise new family. The gene was mapped at chromosome 14q32.1. mRNA mainly expressed in heart, ovary, colon adult tissues....
Background— The purpose of this study was to investigate the clinical importance newly developed ulcer-like projection (ULP) in patients with type B aortic dissection closed and thrombosed false lumen (AD CTFL), which is better known as intramural hematoma. Methods Results— A total 170 acute AD CTFL were admitted our institution from 1986 2008 treated initially medical therapy. There 31 late deaths, including 9 cases rupture. actuarial survival rates all 99%, 89%, 83% at 1, 5, 10 years,...
Background— Observational registries comparing coronary artery bypass graft (CABG) surgery and percutaneous intervention (PCI) have reported long-term survival results that are discordant with those of randomized trials. Methods Results— We conducted a multicenter study in Japan enrolling consecutive patients undergoing first CABG or PCI between January 2000 December 2002. Among 9877 enrolled, 5420 (PCI: 3712, CABG: 1708) had multivessel disease without left main involvement. Because age is...
Previous pathological and clinical studies demonstrated an intimal defect in patients with acute aortic intramural hematoma (IMH). The purpose of this study was to investigate the prevalence outcome detected by multidetector computed tomography (MDCT) IMH.We retrospectively analyzed 38 consecutive IMH whom 64-row MDCT performed during phase (median, 5 days from onset). Intimal defined as continuity disruption inner layer thrombosed false lumen, which could be 1-mm axial longitudinal...
Late adverse events such as very late stent thrombosis (VLST) or target-lesion revascularization (TLR) after first-generation sirolimus-eluting stents (SES) implantation have not been yet fully characterized at long term in comparison with those bare-metal (BMS) implantation.Among 13 058 consecutive patients undergoing first percutaneous coronary intervention the Coronary REvascularization Demonstrating Outcome study-Kyoto registry Cohort-2, 5078 were treated SES only, and 5392 BMS only....