Hideki Okayama
A5056641700- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Hormonal Regulation and Hypertension
- Acute Myocardial Infarction Research
- Renin-Angiotensin System Studies
- Medical Imaging Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Heart Rate Variability and Autonomic Control
- Cardiovascular Effects of Exercise
Ehime Prefectural Central Hospital
2016-2025
Ehime University
2005-2022
Shiga University of Medical Science
2013
Inner Mongolia Medical University
2013
Inner Health
2013
Université Paris Cité
2009
Ehime University Hospital
2009
Institut Cochin
2009
Nagoya Ekisaikai Hospital
1999-2005
In-Q-Tel
2003
<h3>Importance</h3> Very short mandatory dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) with a drug-eluting stent may be an attractive option. <h3>Objective</h3> To test the hypothesis of noninferiority 1 month DAPT compared standard 12 months for composite end point cardiovascular and bleeding events. <h3>Design, Setting, Participants</h3> Multicenter, open-label, randomized clinical trial enrolling 3045 patients who underwent PCI at 90 hospitals in Japan...
<h3>Importance</h3> Clopidogrel monotherapy after short dual antiplatelet therapy (DAPT) percutaneous coronary intervention (PCI) has not yet been fully investigated in patients with acute syndrome (ACS). <h3>Objective</h3> To test the hypothesis of noninferiority 1 to 2 months DAPT compared 12 for a composite end point cardiovascular and bleeding events ACS. <h3>Design, Setting, Participants</h3> This multicenter, open-label, randomized clinical trial enrolled 4169 ACS who underwent...
Late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (MRI) in hypertrophic cardiomyopathy (HCM) has been reported to be associated with myocardial fibrosis and cardiac events. In patients HCM, two-dimensional (2D) strain can identify subclinical global systolic dysfunction despite normal left ventricular (LV) chamber function. Therefore, this study tested the hypothesis that 2D could detect subtle serve as a novel prognostic parameter HCM...
We examined the possibility that continuous activation of human brain renin-angiotensin system causes cognitive impairment, using renin (hRN) and angiotensinogen (hANG) gene chimeric transgenic (Tg) mice. Cognitive function was evaluated by shuttle avoidance test once a week from 10 to 20 weeks age. The rate in wild-type mice gradually increased. In contrast, hRN/hANG-Tg also increased; however, no further increase observed 14 age, it decreased thereafter. Cerebral surface blood flow...
Intravascular ultrasound (IVUS) was only rarely used in landmark trials comparing percutaneous coronary intervention (PCI) with artery bypass grafting (CABG) patients multivessel disease.The authors aimed to evaluate clinical outcomes after optimal IVUS-guided PCI undergoing PCI.The OPTIVUS (OPTimal IntraVascular UltraSound)-Complex study cohort a prospective multicenter single-arm enrolling 1,021 PCI, including left anterior descending using IVUS, aiming meet the prespecified criteria...
Background The class Ia antiarrhythmic drug disopyramide relieves the outflow tract obstruction of hypertrophic obstructive cardiomyopathy (HOCM). Disopyramide, however, has several adverse effects, such as dysuria and thirst, resulting from its anticholinergic activity. A new drug, cibenzoline, little aim this study is to elucidate whether cibenzoline attenuates left ventricular pressure gradient (LVPG) in patients with HOCM. Methods Results Ten HOCM (mean age, 59±12 years) participated...
To elucidate whether there is a difference in the progression of target-organ damage between primary aldosteronism and essential hypertension, we compared left ventricular hypertrophy extracardiac 23 patients with 116 hypertension. The severity hypertensive retinopathy renal involvement were subclinical similar to those hypertension without but significantly milder than hypertrophy. There was strongly significant correlation degree mass index independent office blood pressure In contrast,...
High bleeding risk (HBR) and acute coronary syndrome (ACS) subtypes are critical in determining cardiovascular event after percutaneous intervention (PCI).
High bleeding risk (HBR) and complex percutaneous coronary intervention (PCI) are major determinants for dual antiplatelet therapy (DAPT) duration.The aim of this study was to evaluate the effects HBR PCI on short vs standard DAPT.Subgroup analyses were conducted basis Academic Research Consortium-defined in STOPDAPT-2 (Short Optimal Duration Dual Antiplatelet Therapy After Verulam's-Eluting Cobalt-Chromium Stent-2) Total Cohort, which randomly compared clopidogrel monotherapy after 1-month...
Background: There is a paucity of data on the effect optimal intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) compared with standard PCI or artery bypass grafting (CABG) in patients multivessel disease.
We developed an experimental dog preparation that shows a biphasic bronchoconstriction after allergen exposure. After anesthetization, the dogs were intubated with endotracheal tubes and manually ventilated. Respiratory resistance (Rrs) was measured by forced oscillation method at 3 Hz. Ascaris suum, diluted from 10−5 to 10−2 of extract, inhaled during tidal breathing for 5 min. One hour before antigen challenge, 10 received 70 mg/kg metyrapone (cortisol synthesis inhibitor), 2 h challenge...
Background The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment myocardial blood flow (MBF) adenosine triphosphate (ATP) load technique was investigated present study. Methods and Results study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean 69.2 years) who underwent cine MDCT ATP-load technique. MBF estimated from slope linear regression equation with Patlak plots analysis. overall average 1.83±0.62...
Left ventricular (LV) untwisting velocity has emerged as a novel index of LV diastolic function since it is thought to be related suction. However, the pathophysiology behavior not been fully investigated. The aim this study was investigate determinants peak in patients with dilated cardiomyopathy (DCM).101 DCM (mean age 60 (SD 13) years) and 50 control subjects were evaluated. After standard echocardiographic examination, torsion measured using two-dimensional speckle-tracking imaging....
Background: Right ventricular (RV) pacing alters left (LV) mechanical activation, resulting in adverse impacts on LV function. This study was aimed to investigate the acute effect of RV apical (RVA) and septal (RVS) dyssynchrony function using speckle tracking echocardiography. Methods Results: The 103 patients (749 years) with symptomatic bradyarrhythmia preserved ejection fraction, 50 age-matched control subjects were studied. All received a permanent pacemaker randomly assigned into 2...
The benefit of clopidogrel monotherapy after 1-month dual antiplatelet therapy (DAPT) compared with 12-month DAPT aspirin and was demonstrated in the STOPDAPT-2 (Short Optimal Duration Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2), but not acute coronary syndrome (ACS); however, both trials were underpowered based on actual event rates.
Abstract Purpose Splenic switch-off (SSO) is defined as a decrease in splenic radiotracer uptake following pharmacological stress. This study aimed to assess the clinical utility of SSO on adenosine triphosphate (ATP) 13 N-ammonia positron emission tomography (PET) patients without coronary artery disease (CAD). Materials and Methods We analyzed 63 (mean age, 67 ± 11 years; 34 males) who underwent ATP PET significant CAD invasive angiography or cardiac computed within 6 months. Visual...