A5032830362- Advanced Radiotherapy Techniques
- Neural and Behavioral Psychology Studies
- Cardiac Imaging and Diagnostics
- Radiation Dose and Imaging
- Radiation Therapy and Dosimetry
- Coronary Interventions and Diagnostics
- Neural dynamics and brain function
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Decision-Making and Behavioral Economics
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Memory and Neural Mechanisms
- Hematopoietic Stem Cell Transplantation
- Advanced Neuroimaging Techniques and Applications
- Aortic aneurysm repair treatments
- Advanced MRI Techniques and Applications
- Psychology of Moral and Emotional Judgment
- Asthma and respiratory diseases
- Immune Cell Function and Interaction
- Radiation Effects and Dosimetry
- IL-33, ST2, and ILC Pathways
- Lung Cancer Diagnosis and Treatment
- Visual perception and processing mechanisms
- Acute Myeloid Leukemia Research
Yokohama City University
2016-2025
Kindai University
2009-2025
Kindai University Hospital
2016-2025
National Center For Child Health and Development
2012-2024
Tamagawa University
2015-2024
Kanagawa Cancer Center
2011-2024
Kanagawa Prefectural Hospital Organization
2011-2024
London School of Hygiene & Tropical Medicine
2023
RIKEN Center for Brain Science
2003-2022
Sumitomo Dainippon Pharma (Japan)
2014-2022
Lurasidone [(3a<i>R</i>,4<i>S</i>,7<i>R</i>,7a<i>S</i>)-2-{(1<i>R</i>,2<i>R</i>)-2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-ylmethyl]cyclohexylmethyl}hexahydro-4,7-methano-2<i>H</i>-isoindole-1,3-dione hydrochloride; SM-13496] is an azapirone derivative and a novel antipsychotic candidate. The objective of the current studies was to investigate in vitro vivo pharmacological properties lurasidone. Receptor binding affinities lurasidone several drugs were tested under comparable assay...
Choosing an action that leads to a desired goal requires understanding of the linkages between actions and their outcomes. We investigated neural mechanisms such goal-based selection. trained monkeys on task in which relation visual cues, types, reward conditions changed regularly, selected based anticipated conditions. A significant number neurons medial prefrontal cortex were activated, after cue presentation before motor execution, only by particular action-reward combinations. This...
Contrary to the widespread belief that people are positively motivated by reward incentives, some studies have shown performance-based extrinsic can actually undermine a person's intrinsic motivation engage in task. This “undermining effect” has timely practical implications, given burgeoning of incentive systems contemporary society. It also presents theoretical challenge for economic and reinforcement learning theories, which tend assume monetary incentives monotonically increase...
According to many modern economic theories, actions simply reflect an individual's preferences, whereas a psychological phenomenon called "cognitive dissonance" claims that can also create preference. Cognitive dissonance theory states after making difficult choice between two equally preferred items, the act of rejecting favorite item induces uncomfortable feeling (cognitive dissonance), which in turn motivates individuals change their preferences match prior decision (i.e., reducing...
People act more prosocially when they know are watched by others, an everyday observation borne out studies from behavioral economics, social psychology, and cognitive neuroscience. This effect is thought to be mediated the incentive improve one's reputation, a specific possibly uniquely human motivation that depends on our ability represent what other people think of us. Here we tested hypothesis reputation effects selectively impaired in autism, developmental disorder characterized part...
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) asthma. To explore tissue-specific functions, we inserted a human GoF variant (JAK1GoF) into mice observed the development of spontaneous AD-like skin disease but unexpected resistance lung inflammation when JAK1GoF expression was restricted stroma. We...
The cognitive flexibility to select appropriate rules in a changing environment is essential for survival and assumed depend on the integrity of prefrontal cortex (PFC). To explore contribution dorsolateral PFC flexible rule-based behavior, we recorded activity cells this region monkeys performing Wisconsin Card Sorting Test (WCST) analog. monkey had match sample one three test items by either color or shape. Liquid reward discrete visual signal (error signal) were given as feedback correct...
Recent studies have documented that self-determined choice does indeed enhance performance. However, the precise neural mechanisms underlying this effect are not well understood. We examined correlates of facilitative effects using functional magnetic resonance imaging (fMRI). Participants played a game-like task involving stopwatch with either they selected (self-determined-choice condition) or one were assigned without (forced-choice condition). Our results showed enhanced performance on...
Abstract: Topical corticosteroids (TCS) are first‐line therapeutic agents for atopic dermatitis (AD). Some patients express irrational fear and anxiety about using TCS, which leads to poor outcomes AD. Although it is important understand the factors underlying steroid phobia so that its effects can be minimized, few studies have addressed this subject. Here, we used a questionnaire investigate predictive in caregivers (usually mothers) of children with We studied 436 AD (mean age 47.6 mos,...
AbstractThe objective of the study was to assess effectiveness group counseling, using a problem-solving therapy approach, on reducing depressive symptoms and increasing prenatal disclosure rates HIV status among HIV-positive pregnant women living in Dar es Salaam, Tanzania. A randomized controlled trial performed comparing six-week structured nurse–midwife facilitated psychosocial support with standard care. Sixty percent intervention were depressed post-intervention, versus 73% control...
Previous studies have reported that insulin resistance plays an important role in the progression of atherosclerosis. However, relationship between and coronary plaque instability is not well established. The purpose this study was to assess characteristics identified by optical coherence tomography (OCT).This enrolled 155 consecutive patients undergoing percutaneous intervention. OCT image acquisitions were performed culprit lesions. Insulin using homeostasis model assessment (HOMA-IR)....
Many investigators have speculated that hyperintense plaques (HIPs) of the carotid artery on non-contrast T1-weighted imaging (T1WI) in magnetic resonance indicate presence mural or intraplaque haemorrhage containing methemoglobin. Coronary plaque with T1WI is challenging, and clinical significance coronary HIP remains unknown. The aim this study was to compare HIPs morphology assessed by optical coherence tomography (OCT), which allows us identify not only rupture, but also fibrous cap...
We investigated the impact of age-related macular degeneration (AMD) on visual acuity and white matter. combined an adaptive cortical atlas diffusion-weighted magnetic resonance imaging (dMRI) tractography to separate optic radiation (OR) projections different retinal eccentricities in human primary cortex. exploited known anatomical organization OR clinically relevant data segment into three components projecting fovea, mid- far-periphery. measured matter tissue properties-fractional...
Knowledge about one’s personality, the self-concept, shapes human experience. Social cognitive neuroscience has made strides addressing question of where and how self is represented in brain. The answer, however, remains elusive. We conducted two functional magnetic resonance imaging experiments (the second preregistered) with male female participants employing a self-reference task broad range attributes carrying out searchlight representational similarity analysis. importance to...
1. The responses of single neurons in the anterior part temporal cortex monkeys, mainly temporopolar cortex, area 36, and most TE von Bonin Bailey (1947) (these areas were designated here as pole), examined during performance a visual recognition memory task. stimulus (sample stimulus) was presented when monkey pressed lever. same sample one to four times and, thereafter, new presented. monkeys trained discriminate from release lever response stimulus. We used colored photographs natural...
A distinct aspect of the sense fairness in humans is that we care not only about equality material rewards but also nonmaterial values. One such value opportunity to choose freely among many options, often regarded as a fundamental right economic freedom. In modern developed societies, equal opportunities work, living, and lifestyle are enforced by antidiscrimination laws. Despite widespread endorsement opportunity, no studies have explored how people assign it. We used functional magnetic...
Previous pathohistological studies demonstrated that cholesterol crystals (CCs) are frequently observed in atherosclerotic plaques, and usually present abundantly vulnerable plaques. However, the role of CCs plaque destabilization, as well their origin composition, is unknown. Optical coherence tomography (OCT) imaging system a high-resolution device, which allows vivo identification accumulating within The aim this study was to investigate relationship between presence CCs, other...
Abstract Background Management of respiratory motion during radiation therapy is essential for accurate dose delivery and minimizing the risk to organs. In diagnostic imaging, monitoring required confirmation breath‐hold four‐dimensional computed tomography (CT) reconstruction. Although systems are widely used in therapy, they not often where could improve image quality. Purpose The purpose this study was use a millimeter‐wave sensor (MWS) noninvasively visualize motion, confirm...