A5053157203- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Steroid Chemistry and Biochemistry
- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Stress Responses and Cortisol
- Soft tissue tumor case studies
- Genetics, Aging, and Longevity in Model Organisms
- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Circadian rhythm and melatonin
- Sex and Gender in Healthcare
- Contact Dermatitis and Allergies
- Immunodeficiency and Autoimmune Disorders
- Neurofibromatosis and Schwannoma Cases
- Mast cells and histamine
Icahn School of Medicine at Mount Sinai
2023-2025
Keio University
2014-2023
Allen Institute for Brain Science
2023
Nerima General Hospital
2020
RIKEN Center for Integrative Medical Sciences
2017
Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with JAK1 gain-of-function (GoF) variants develop atopic dermatitis (AD) asthma. To explore tissue-specific functions, we inserted a human GoF variant (JAK1GoF) into mice observed the development of spontaneous AD-like skin disease but unexpected resistance lung inflammation when JAK1GoF expression was restricted stroma. We...
Visceral pain disorders such as interstitial cystitis/bladder syndrome (IC/BPS) and irritable bowel (IBS) often manifest concurrently in the bladder colon. Yet, mechanistic basis of comorbidities transmission neural hypersensitivity across organ systems has remained a mystery. Here, we identify mast cell-sensory neuron circuit that initiates inflammation simultaneously propagates to colon murine model IC/BPS. We unveil anatomic heterogeneity cells relation nociceptors their critical...
Significance Immune tolerance is crucial to prevent harmful immune reactions against self-antigens and well operated by central thymic peripheral tissue tolerance. However, had been investigated under influence from We successfully decoupled utilizing autoantigen-deficient thymus. Experiments revealed that self-antigen presentation in steady state initiated proliferation but subsequent disappearance of autoreactive CD4 + T cells draining lymph nodes. After screening representative...
Interleukin-27 (IL-27) is an immunoregulatory cytokine whose essential function to limit immune responses. We found that the gene encoding cholesterol 25-hydroxylase (Ch25h) was induced in CD4
Abstract Drug‐induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug adverse skin eruption visceral organ involvement. The characteristic clinical features of DIHS/DRESS are reactivation human herpesviruses (HHV) the development autoimmune diseases, but their pathogenesis associations not yet understood. Here, we report 66‐year‐old man who presented fever, generalized erythema, diffuse lymphadenopathy, diarrhea after 3 weeks...
Abstract The pathological mechanisms and immunological kinetics of drug‐induced hypersensitivity syndrome (DIHS), including the relevance interleukin (IL)‐6, remain unclear. We report a case drug adverse reaction that does not fulfill diagnostic criteria DIHS but mimics its characteristic features. Because patient was under anti‐IL‐6 therapy at onset, some symptoms typically seen in were absent, such as fever leukocyte count abnormalities. However, features clearly observed subsequent...
Pemphigus vulgaris is an autoimmune blistering disease caused by IgG targeting desmoglein 3 (Dsg3), adhesion molecule of keratinocytes. Anti-Dsg3 production prevented in healthy individuals, but it unclear how Dsg3-specific B cells are regulated. To clarify the immunological condition regulating cells, a pathogenic anti-Dsg3 Ig (AK23) knock-in mouse was generated. AK23 developed normally without undergoing deletion or acquiring anergic phenotype vivo. The showed Ca2+ influx upon IgM...
Various autoimmune responses increase with age, but the underlying mechanism is not clear. In this study, we used CD4+ T cells expressing a transgenic cell receptor specific for desmoglein 3 (Dsg3), which target antigen of bullous disease pemphigus vulgaris, to examine how peripheral immunological tolerance against pathogenic autoreactive changes age. Dsg3-specific were deleted within 14 days after adoptive transfer into young mice (8 weeks old), while they escaped deletion when transferred...
Natto (fermented soybeans)-induced hypersensitivity is characterized by delayed symptom onset that hampers diagnosis. We aimed to clarify the clinical utility of basophil activation test (BAT) in diagnosis natto-induced hypersensitivity.Five patients with a history anaphylaxis and chronic urticaria suspected seven spontaneous clinically unrelated natto were enrolled patient control groups, respectively. The BAT was performed two incubation times, 15 min 1 h, combination various...
Peripheral tolerance against H1 T cells needed MHC II-restricted an:gen presenta:on and depended on CCR7 ※3※3 Chemokine receptor molecule which regulate immune cell migra4on Tregs were indispensable for the peripheral cellsIn absence of Tregs, remained evokeed derma44s. Dsg3ー Dsg3+Gated in Vβ6 + SLN Gated CD8 CD4 Chimeric model (nude Dsg3-KO thymus) Control 1 (Dsg3-KO) 2 +WT ＋
Segmental neurofibromatosis (SNF) is a mosaic form of type I (NF1) caused by prenatal somatic mutation in NF1.1 Various tumors can develop patients with SNF and systemic neurofibromatosis, including neurofibromas, malignant peripheral nerve sheath tumors, gastric adenocarcinomas.2,3 originate from cells that bear NF1 mutation. Mosaic skin disorders exhibit several characteristic patterns lesions, Blaschko-linear, checkerboard, phylloid, patchy patterns, depending on the cell bears causative