A5100444411- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Soft Robotics and Applications
- Inflammasome and immune disorders
- Robotics and Sensor-Based Localization
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Parallel Computing and Optimization Techniques
- Robotic Path Planning Algorithms
- T-cell and B-cell Immunology
- Cloud Computing and Resource Management
- Distributed and Parallel Computing Systems
- Gastrointestinal motility and disorders
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
- Forest Insect Ecology and Management
- Osteomyelitis and Bone Disorders Research
- T-cell and Retrovirus Studies
- Micro and Nano Robotics
- Bacterial Genetics and Biotechnology
- Aluminum toxicity and tolerance in plants and animals
- Single-cell and spatial transcriptomics
- Inflammation biomarkers and pathways
- Hematopoietic Stem Cell Transplantation
Cornell University
2020-2025
Fuzhou University
2022-2025
Institute of Food Science and Technology
2022-2025
University of Georgia
2018-2024
Zhejiang Chinese Medical University
2023
Weill Cornell Medicine
2023
Tsinghua University
2009-2022
Northwest Women's and Children's Hospital
2022
Center for Life Sciences
2018-2020
Peking Union Medical College Hospital
2020
Abstract CD8 + T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1, an acts brakes to prevent cell overreaction under normal conditions but exploited tumor cells escape immune surveillance. Immune checkpoint inhibitors have revolutionized therapeutics removing such brakes. Unfortunately, only a minority of patients respond immunotherapies presumably due inadequate immunity. Antitumor immunity depends on activation...
Group 2 innate lymphoid cells (ILC2s) are a specialized subset of effector that critically involved in allergic responses; however, the mechanisms their regulation remain unclear. We report conditional deletion E3 ubiquitin ligase VHL progenitors minimally affected early-stage bone marrow ILC2s but caused selective and intrinsic decrease mature ILC2 numbers peripheral non-lymphoid tissues, resulting reduced type immune responses. deficiency accumulation hypoxia-inducible factor 1α (HIF1α)...
Activated ILC2s use the ChAT-acetylcholine pathway to enhance their cytokine production and promote helminth expulsion.
Innate lymphoid cells (ILCs) can promote host defense, chronic inflammation, or tissue protection and are regulated by cytokines neuropeptides. However, their regulation diet microbiota-derived signals remains unclear. We show that an inulin fiber promotes Tph1-expressing inflammatory ILC2s (ILC2INFLAM) in the colon, which produce IL-5 but not tissue-protective amphiregulin (AREG), resulting accumulation of eosinophils. This exacerbates inflammation a murine model intestinal damage ILC2-...
Abstract Wall-climbing robots work on large steel components with magnets, which limits the use of wireless sensors and magnetometers. This study aims to propose a novel autonomous localisation method (RGBD-IMU-AL) an inertial measurement unit fixed RGB-D camera improve performance wall-climbing robots. The contains five modules: calibration, tracking, three-dimensional (3D) reconstruction, location attitude estimation. calibration module is used obtain initial angle. tracking 3D...
This study aimed to investigate the molecular mechanism of Pseudomonas with varying adhesion capabilities Tilapia's intestinal mucus influence spoilage potential Tilapia. Sodium chloride(NaCl) was used as an environmental factor regulate Pseudomonas' ability. After being exposed 3.5% NaCl stress, PS01 strain low showed enhancement in ability, while LP-3 high exhibited a decrease. Correspondingly, expression critical genes, such flgC, fliC, and cheB, found be altered. LP-3, observed promote...
Visceral pain disorders such as interstitial cystitis/bladder syndrome (IC/BPS) and irritable bowel (IBS) often manifest concurrently in the bladder colon. Yet, mechanistic basis of comorbidities transmission neural hypersensitivity across organ systems has remained a mystery. Here, we identify mast cell-sensory neuron circuit that initiates inflammation simultaneously propagates to colon murine model IC/BPS. We unveil anatomic heterogeneity cells relation nociceptors their critical...
Metabolic pathways such as glycolysis or oxidative phosphorylation play a key role in regulating macrophage function during inflammation and tissue repair. However, how exactly the VHL–HIF–glycolysis axis is involved of tissue-resident macrophages remains unclear. Here we demonstrate that loss VHL myeloid cells resulted attenuated pulmonary type 2 fibrotic responses, accompanied by reduced eosinophil infiltration, decreased IL-5 IL-13 concentrations, ameliorated fiber deposition upon...
Shewanella putrefaciens is a typical spoilage bacteria organism in seafood. The adhesion ability of three S. strains (HR-15, JR-18, HC-71) isolated from putrefied tilapia were evaluated by mucus vitro and intestinal vivo. results the inoculated fish fillets refrigerated both showed that was positively correlated with ability. High-throughput sequencing GC-MS high also significantly changed flora fish, causing an increase such as Plesionomas, Macellibacteroides, Acinetobacter, Legionella,...
Abstract Dopamine receptors are involved in several immunological diseases. We previously found that dopamine D3 receptor (D3R) on mast cells showed a high correlation with disease activity patients rheumatoid arthritis, but the mechanism remains largely elusive. In this study, murine collagen-induced arthritis (CIA) model was employed both DBA/1 mice and D3R knockout mice. Here, we revealed D3R-deficient developed more severe than wild-type suppressed cell activation vivo vitro via...
Abstract The thymus is a primary lymphoid organ generating self-restricted and self-tolerant naïve T-cells. Early in life the starts to involute, resulting decreased T-cell output which may be more self-reactive, leading an increased prevalence of autoimmunity. A decrease transcription factor FOXN1 early event thymic involution. Using Foxn1 lacz model, we studied how premature involution affects microenvironment, thymocytes, peripheral T cell immunity. We found that led aged-like epithelial...
Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) have the ability to treat cardiovascular diseases (CVDs). We explored their mechanism on pyroptosis modulation in cardiac microvascular endothelial cells (CMECs).Exosomes were extracted from hUCMSCs using a differential high-speed centrifugation method, and then identified by transmission electron microscopy, nanoparticle tracking analysis, Western blot analysis. Later, CMECs induced hypoxia/reoxygenation (H/R) vitro...
Background Hematopoietic stem cells (HSCs) derived from birth through adult possess differing differentiation potential for T or B cell fate in the thymus; neonatal bone marrow (BM) also have a higher production BM compared to HSCs. We hypothesized that this hematopoietic-intrinsic might regulate development thymus during ontogeny. Methods Foxn1lacZ mutant mice are model which down regulation of thymic epithelial (TEC) specific transcription factor beginning one week postnatal causes...
Abstract Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell responses, but mechanisms controlling these distinct outcomes remain poorly understood and accumulating evidence indicates that aberrant immunity to intestinal microbiota is causally associated with infectious, inflammatory, malignant diseases 1–8 . Here, we define a critical pathway fate versus cells are specific for express transcription factor RORγt. We profiled all RORγt + immune at...