A5100693144- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Circular RNAs in diseases
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- Neurological Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Heart Rate Variability and Autonomic Control
- Inflammasome and immune disorders
- Gut microbiota and health
- Optical Imaging and Spectroscopy Techniques
- Tryptophan and brain disorders
- Protein Hydrolysis and Bioactive Peptides
- Neurological Disease Mechanisms and Treatments
- Phosphodiesterase function and regulation
- Biosensors and Analytical Detection
- Cancer-related Molecular Pathways
- Aquaculture Nutrition and Growth
- Functional Brain Connectivity Studies
- Insect Utilization and Effects
- Animal and Plant Science Education
Icahn School of Medicine at Mount Sinai
2025
Xinxiang University
2024
Yangzhou University
2014-2024
Hunan Institute of Science and Technology
2024
Guangxi University of Chinese Medicine
2011-2023
Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2023
Guangxi University
2014-2022
Creative Commons
2022
The aim of the research was to obtain a high healthcare honeysuckle beverage with strong antioxidant activity. Honeysuckle ( Lonicera japonica Thunb ) used as raw material in this experiment. effects fermentation temperature, time, lactic acid bacteria inoculation amount, and sugar addition amount on sensory quality were investigated by single factor test orthogonal test, best process obtained. physicochemical indexes activity beverages fermented studied. results showed that temperature 37...
Visceral pain disorders such as interstitial cystitis/bladder syndrome (IC/BPS) and irritable bowel (IBS) often manifest concurrently in the bladder colon. Yet, mechanistic basis of comorbidities transmission neural hypersensitivity across organ systems has remained a mystery. Here, we identify mast cell-sensory neuron circuit that initiates inflammation simultaneously propagates to colon murine model IC/BPS. We unveil anatomic heterogeneity cells relation nociceptors their critical...
Abstract A label‐free DNA biosensor based on three‐dimensional reduced graphene oxide (3D‐rGO) and polyaniline (PANI) nanofibers modified glassy carbon electrode (GCE) was successfully developed for supersensitive detection of breast cancer BRCA1. The results demonstrated that 3D‐rGO PANI had synergic effects reducing the charge transfer resistance ( R ct ), meaning a huge enhancement in electrochemical activity 3D‐rGO‐PANI/GCE. Probe could be immobilized 3D‐rGO‐PANI/GCE special sensitive...
Primary liver cancer is the third most common malignancy, and hepatocellular carcinoma its main subtype, with a high recurrence rate mortality. Intestinal microflora metabolic disorders are present in HCC patients. Traditional Chinese medicine (TCM) plays an important role composition of intestinal microorganisms transformation active metabolites. Many scholars trying to develop related drugs assist treatment cancer. In preliminary study research group, it was found that Jiawei Xiaoyao San...
Disrupted-In-Schizophrenia 1 (DISC1) is a genetic risk factor implicated in major mental disorders that involve disrupted neurodevelopment and synaptic signaling. Glial cells such as astrocytes can regulate neuronal maturation. Although express DISC1, the role of astrocyte DISC1 regulation remains unknown. We expressed pathogenic, dominant-negative form mutant to elucidate roles astrocytic maturation dendrites excitatory inhibitory synapses using co-culture model. found wild-type primary...
Abstract Background Schistosoma infection is a significant public health issue, affecting over 200 million individuals and threatening 700 people worldwide. The species prevalent in China japonicum . Recent studies showed that both gut microbiota metabolome are closely related to schistosomiasis caused by S. , but clinical study limited the underlying mechanism largely unclear. This aimed explore alterations as well function of metabolite profile patients with infection. Methods included 20...
Disrupted‐in‐schizophrenia 1 (DISC1) is a genetic risk factor that has been implicated in major mental disorders. DISC1 binds to and stabilizes serine racemase regulate production of D‐serine by astrocytes, contributing glutamate (GLU) neurotransmission. However, the possible involvement astrocytic synthesis, metabolism, reuptake, or secretion GLU remains unexplored. Therefore, we studied effects dominant‐negative mutant on various aspects metabolism using primary astrocyte cultures...
Detection of circulating tumor-specific DNA, RNA or proteins can be difficult due to relative scarcity. Exosomes are extracellular vesicles, 30 - 150 nm in diameter derived from fusion multivesicular bodies with the plasma membrane. They composed a lipid bilayer membrane and contain proteins, mRNA miRNA. secreted by multiple cell types, including cancer cells. However, there is lack information concerning contents exosomes various tumor types. To examine cancer, we collected blood samples...
Mechanical forces play a key role in the initiation and progression of cancer. Intercellular interactions between fibroblasts cancer cells contribute large portion mechanical tumor tissue. Hence, further investigation force-mediated intercellular is urgently needed, given slow progress management various solid cancers. In our previous study, we observed obvious hepatocellular carcinoma (HCC) through integrins ECM proteins by using coculture model discovered that these important roles 3D...
Chronic visceral pain is a typical condition associated with inflammation. The mechanism of in chronic abdominal syndromes, such as irritable bowel syndrome and pancreatitis, poorly understood its treatment has been largely empirical, an outcome that variable frequently unsatisfactory. Human experimental studies have indicated critical role neuronal mechanisms result peripheral central sensitization.1–3 nociceptive sensitization, literally meaning sensitization to noxious stimuli, begins the...
Despite the recent progress in psychiatric genetics, very few studies have focused on genetic risk factors glial cells that, compared to neurons, can manifest different molecular pathologies underlying disorders. In order address this issue, we studied effects of mutant disrupted schizophrenia 1 (DISC1), a factor for schizophrenia, cultured primary neurons and astrocytes using an unbiased mass spectrometry-based proteomic approach. We found that selective expression DISC1 affects wide...
Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation this area. In study, we identified overexpression of zinc finger, X-linked, duplicated family member C (ZXDC) CC tissue with metastasis, which correlates poor outcomes patients. We observed that ZXDC promotes, while silencing inhibits metastasis cells both vitro and vivo. Additionally, our research demonstrated activated RhoA/ROCK signaling pathway, leading...
Abstract A series of macroporous beaded terpolymers with epoxy groups were synthesized by suspension polymerization glycidyl methacrylate (GMA), ethylene glycol dimethacrylate (EGDMA), and the third monomers including styrene, methyl methacrylate, n ‐butyl acrylate (BA), butyl (BMA), 2‐hydroxyethyl for immobilization Candida lipolytica lipase. The effect various on loading activity recovery immobilized lipase studied. Terpolymers BA as monomer found to give biggest lipase, poly(GMA‐EGDMA‐BA)...
Aberrant expression of microRNAs (miRNAs) has been reported to play a role in tumorigenesis. Dysfunction miR-1296 was found variety cancers, however, the function progression glioma remains largely understood. Here, our results showed that significantly down-regulated tissues and cell lines. Decreased associated with tumor size, WHO grade karnofsky performance scale (KPS) patients. Low correlated shorter 5-year overall survival Overexpression inhibited proliferation, colony formation,...
Gastric cancer is a global health problem. In this study, we investigate the role of novel Indole derivative, named LCT-3d, in inhibiting growth gastric cells by MTT assay. The Western blotting results showed that LCT-3d modulated mitochondrial-related proteins and Cleaved-Caspases 3/9, to induce cell apoptosis. up-regulation Death receptor 5 (DR5) MGC803 was observed with treatment. Knockdown DR5 on partially reversed LCT-3d-induced mitochondrial level Reactive Oxygen Species (ROS)...
Abstract The modified Wenyang Huayu decoction has been widely used to treat vascular dementia in China for thousands of years. We have previously proved that a version, Wuzang the potential be more effective clinical treatment can attenuate cerebral ischaemic injury. However, global transcript profile and signalling conduction pathways regulated by this recipe remains unclear. This study established two‐vessel occlusion rat model bilateral common carotid artery occlusion. Two groups rats...