A5101806000- Spine and Intervertebral Disc Pathology
- Functional Brain Connectivity Studies
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Kidney Stones and Urolithiasis Treatments
- Software Testing and Debugging Techniques
- Software Reliability and Analysis Research
- Advanced Neuroimaging Techniques and Applications
- Quantum Information and Cryptography
- Neural dynamics and brain function
- Pediatric Urology and Nephrology Studies
- Polymer crystallization and properties
- Quantum and electron transport phenomena
- Viral gastroenteritis research and epidemiology
- biodegradable polymer synthesis and properties
- Cervical and Thoracic Myelopathy
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Polymer Nanocomposites and Properties
- Quantum Computing Algorithms and Architecture
- Metastasis and carcinoma case studies
- Medical Imaging and Analysis
- Genetic Mapping and Diversity in Plants and Animals
- Landslides and related hazards
Central South University
2019-2025
Xiangya Hospital Central South University
2019-2025
Chinese People's Liberation Army
2021-2025
Sun Yat-sen University
2023-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2023-2025
University of Zurich
2025
Czech Academy of Sciences, Institute of Physiology
2025
National Clinical Research
2025
Taiyuan Heavy Industry (China)
2025
Chenzhou First People's Hospital
2021-2024
Abstract Here we report a breakthrough in the fabrication of long lifetime transmon qubit. We use tantalum films as base superconductor. By using dry etching process, obtained qubits with best T 1 503 μs. As comparison, also fabricated other popular materials, including niobium and aluminum, under same design processes. After characterizing their coherence properties, found that prepared have performance. Since process is stable highly anisotropic, it much more suitable for fabricating...
ABSTRACT The CRISPR-Cas9 system is a powerful and revolutionary genome-editing tool for eukaryotic genomes, but its use in bacterial genomes very limited. Here, we investigated the of Streptococcus pyogenes editing genome Clostridium cellulolyticum , model microorganism bioenergy research. Wild-type Cas9-induced double-strand breaks were lethal to C. due minimal expression nonhomologous end joining (NHEJ) components this strain. To circumvent lethality, Cas9 nickase was applied develop...
Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor (TNF) α induced NFκB activity, cylcooxygenases (COX-1 COX-2), aromatase, nitric oxide production in endotoxin-stimulated macrophages, proliferation KB or MCF7 cells, induction quinone reductase 1 (QR1), accumulation the sub-G1 phase cell cycle, quenching 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. Two showed activity these assays;...
Rationale: Bioactive lipid mediators, derived from membrane precursors, are released into the airway and airspace where they bind high-affinity cognate receptors may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive mediator generated by enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array biological actions on cell proliferation, migration, survival, differentiation, motility, therefore could pathogenesis.Objectives: To define...
The chemoresistance of colon cancer to oxaliplatin (L-OHP) indicates poor prognosis. Long non-coding RNA (lncRNA) KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1) has been shown participate in the tumorigenesis several types cancers. However, little is known about role and prognosis cancer.Quantitative-PCR Western blot were used measure expression profiles KCNQ1OT1, miR-34a, Atg4B tissues cells. Cell viability assay flow cytometry examine their effects on cell proliferation death....
Abstract Huntington’s disease is an autosomal-dominant neurodegenerative caused by CAG expansion in exon 1 of the huntingtin (HTT) gene. Since mutant (mHTT) protein root cause disease, oligonucleotide-based therapeutic approaches using small interfering RNAs (siRNAs) and antisense oligonucleotides designed to specifically silence mHTT may be novel strategies for disease. Unfortunately, lack effective vivo delivery system remains a major obstacle realizing full potential oligonucleotide...
The aim of the research was to obtain a high healthcare honeysuckle beverage with strong antioxidant activity. Honeysuckle ( Lonicera japonica Thunb ) used as raw material in this experiment. effects fermentation temperature, time, lactic acid bacteria inoculation amount, and sugar addition amount on sensory quality were investigated by single factor test orthogonal test, best process obtained. physicochemical indexes activity beverages fermented studied. results showed that temperature 37...
Abstract Background The R1441G mutation in the leucine-rich repeat kinase 2 (LRRK2) gene results late-onset Parkinson’s disease (PD). Peripheral inflammation and gut microbiota are closely associated with pathogenesis of PD. Chronic periodontitis is a common type peripheral inflammation, which Porphyromonas gingivalis (Pg), most bacterium causing chronic periodontitis, can cause alteration microbiota. It not known whether Pg-induced dysbiosis plays role pathophysiology Methods In this study,...
Abstract A metaheuristic algorithm that simulates the foraging behavior of remora has been proposed in recent years, called ROA. ROA mainly host parasitism and switching remora. However, experiment, it was found there is still room for improvement performance When dealing with complex optimization problems, often falls into local optimal solutions, also problem too-slow convergence. Inspired by natural rule “Survival fittest”, this paper proposes a random restart strategy to improve ability...
In this paper, we propose a face-hallucination method, namely face hallucination based on sparse local-pixel structure. our framework, high resolution (HR) is estimated from single frame low (LR) with the help of facial dataset. Unlike many existing methods such as structure to global image super-resolution method (LPS-GIS) and through neighbor embedding, where prior models are learned by employing least-square methods, framework aims shape model using representation. Then employed guide...
Abstract Introduction Microspheres fabricated from natural materials serve as a promising biodegradable and biocompatible carrier in small volume for efficient cell delivery to the lesion of injured neural tissue generate biological functions. As major component extracellular matrix due its abundance within body, collagen may be into microspheres improve ability pre-seeded cells on encounter hostile micro-environment lesion. Methods In this study, were using water-in-oil emulsion technique...
Nanofiber-based scaffolds may simultaneously provide immediate contact guidance for neural regeneration and act as a vehicle therapeutic cell delivery to enhance axonal myelination. Additionally, nanofibers can serve neuron-free model study myelination of oligodendrocytes. In this study, we fabricated using polycaprolactone gelatin copolymer. The ratio the component in fibers was confirmed by energy dispersive X-ray spectroscopy. addition (PCL) nanofiber fabrication decreased angle...
Given that anorexia nervosa (AN) is a life-threatening mental disorder and has poor clinical outcomes, novel effective treatments are warranted, especially for severe persistent cases.To investigate the safety, feasibility, outcomes of using deep brain stimulation (DBS) nucleus accumbens (NAcc) in treatment-refractory AN patients.A total 28 women with refractory underwent NAcc-DBS completed this 2-year follow-up study. The including body mass index (BMI) mood, anxiety, obsessive symptoms,...
Abstract Endovascular embolization can selectively deploy embolic agents into diseased or injured blood vessels to complete the treatment. However, traditional still face challenges, such as poor intravascular diffusivity, non‐biodegradable, unstable mechanical properties, radiolucency, and recanalization. Herein, we report a poly (lipoic acid‐tannic acid)/tromethamine/Galinstan (PLTTG) dimethyl sulfoxide (DMSO) solution‐derived hydrogel liquid agent. By injecting PLTTG DMSO solution body...