A5087181527- Transplantation: Methods and Outcomes
- Natural product bioactivities and synthesis
- Organ Transplantation Techniques and Outcomes
- Polysaccharides and Plant Cell Walls
- Bioactive Compounds and Antitumor Agents
- Mechanical Circulatory Support Devices
- Cancer-related gene regulation
- Seaweed-derived Bioactive Compounds
- Epigenetics and DNA Methylation
- Signaling Pathways in Disease
- Genomics, phytochemicals, and oxidative stress
- Macrophage Migration Inhibitory Factor
- Neonatal Respiratory Health Research
- Inflammasome and immune disorders
- Immune cells in cancer
- Fungal Biology and Applications
- Sphingolipid Metabolism and Signaling
- Phytochemistry and Biological Activities
- Morinda citrifolia extract uses
- Bioactive natural compounds
- Histone Deacetylase Inhibitors Research
- Hibiscus Plant Research Studies
- Immune Response and Inflammation
- Synthesis and biological activity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
The Ohio State University Wexner Medical Center
2014-2024
The Ohio State University
2014-2023
Kangwon National University
2007-2013
University of Illinois Chicago
2013
Jesse Brown VA Medical Center
2013
Although alveolar macrophages (AMs) from patients with asthma are known to be functionally different those of healthy individuals, the mechanism by which this transformation occurs has not been fully elucidated in asthma. The goal study was define mechanisms that control AM phenotypic and functional response acute allergic airway inflammation. phenotype characteristics AMs obtained human subjects after subsegmental bronchoprovocation allergen studied. Using macrophage-depleted mice, role...
Rationale: Bioactive lipid mediators, derived from membrane precursors, are released into the airway and airspace where they bind high-affinity cognate receptors may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive mediator generated by enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array biological actions on cell proliferation, migration, survival, differentiation, motility, therefore could pathogenesis.Objectives: To define...
The transcription factor PU.1 is involved in regulation of macrophage differentiation and maturation. However, the role alternatively activated (AAM) asthmatic inflammation has yet been investigated. Here we report that serves as a critical regulator AAM polarization promotes pathological progress airway inflammation. In response to challenge DRA (dust mite, ragweed, Aspergillus) allergens, conditional PU.1-deficient (PU/ER(T)(+/-)) mice displayed attenuated allergic inflammation, including...
Abstract Macrophages are a heterogeneous population of immune cells that essential for the initiation and containment inflammation. There 2 well-established populations inflammatory macrophages: classically activated M1 alternatively M2 macrophages. The FoxO family transcription factors plays key roles in number cellular processes, including cell growth, metabolism, survival, In this study, we determined whether expression FoxO1 contributes polarization macrophages toward M2-like phenotype...
// Sangwoon Chung 1 , Tae Jin Lee 2 Brenda F. Reader Ji Young Kim Yong Gyu Gye Park 3 Manjula Karpurapu Megan N. Ballinger Feng Qian Luiza Rusu Hae 4 Terry G. Unterman 5 Carlo M. Croce and John W. Christman Pulmonary, Allergy, Critical Care Sleep Medicine, Ohio State University Wexner Medical Center, Davis Heart Lung Research Institute, Columbus, Ohio, USA Department of Molecular Virology, Immunology Genetics Comprehensive Cancer University, Section Care, Illinois at Chicago, Illinois,...
Cinnamaldehyde (CA) has been known to exhibit anti-inflammatory and anticancer effects. Although numerous pharmacological effects have demonstrated, regulatory effect of CA on the functional activation monocytes macrophages not fully elucidated yet. To evaluate its monocyte/macrophage-mediated immune responses, activated by lipopolysaccharide (LPS), treated with proaggregative antibodies, extracellular matrix protein fibronectin were employed. was able suppress both production nitric oxide...
Allergic eosinophilic asthma is a chronic condition causing airway remodeling resulting in lung dysfunction. We observed that expression of sirtuin 2 (Sirt2), histone deacetylase, regulates the recruitment eosinophils after sensitization and challenge with triple antigen: dust mite, ragweed, Aspergillus fumigatus (DRA). Our data demonstrate IL-4 Sirt2 isoform 3/5. Pharmacological inhibition by AGK2 resulted diminished cellular recruitment, decreased CCL17/TARC, reduced goblet cell...
The role of different lineage specific transcription factors in directing hematopoietic cell fate towards myeloid is well established but the status epigenetic modifications has not been defined during this important developmental process. We used non proliferating, PU.1 inducible progenitor cells and differentiating bone marrow derived macrophages to study dependent KLF4 transcriptional regulation its promoter demethylation monocyte/macrophage differentiation. Expression was regulated by...
The role of the transcription factor nuclear activated T cells (NFAT) was initially identified in and B cell gene expression, but its regulating expression macrophages during sepsis is not known. Our data show that NFATc3 regulates inducible nitric oxide synthase (iNOS) stimulated with lipopolysaccharide. Selective inhibition NFAT by cyclosporine A a competitive peptide inhibitor 11R-VIVIT inhibited endotoxin-induced iNOS (NO) release. Macrophages from knockout (KO) mice reduced NO release...
Specific therapies targeting cellular and molecular events of sepsis induced Acute Lung Injury (ALI) pathogenesis are lacking. We have reported a pivotal role for Nuclear Factors Activated T cells (NFATc3) in regulating macrophage phenotype during ALI subsequent studies demonstrate that NFATc3 transcriptionally regulates CCR2 TNFα gene expression. Mouse pulmonary microvascular endothelial cell monolayer maintained tighter barrier function when co-cultured with LPS stimulated deficient...