A5100656766- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Berberine and alkaloids research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- interferon and immune responses
- Inflammatory mediators and NSAID effects
- Sphingolipid Metabolism and Signaling
- Drug Transport and Resistance Mechanisms
- Synthesis and bioactivity of alkaloids
- Autoimmune and Inflammatory Disorders Research
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Medicinal Plants and Bioactive Compounds
- Eicosanoids and Hypertension Pharmacology
- Cholesterol and Lipid Metabolism
- Transplantation: Methods and Outcomes
- Gastric Cancer Management and Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Lung Cancer Treatments and Mutations
- Protein Tyrosine Phosphatases
- Inflammation biomarkers and pathways
- Cancer, Stress, Anesthesia, and Immune Response
Harbin Medical University
2008-2025
Second Affiliated Hospital of Harbin Medical University
2007-2025
TGF-β promotes tumor invasion and metastasis through inducing epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Circular RNAs (circRNAs) are recognized as functional non-coding involved human cancers. However, whether how circRNAs contribute to TGF-β-induced EMT NSCLC remain vague. Here, we investigated the regulation function of RNA hsa_circ_0008305 (circPTK2) metastasis, well a link between circPTK2 transcriptional intermediary factor 1 γ (TIF1γ) NSCLC. were...
To evaluate the effect of p53 on pyroptosis and its inhibitory role tumor growth in non-small-cell lung cancer (NSCLC). The correlation was determined tissues NSCLC patients. pyroptotic level detected A549 cells to clarify pyroptosis. overexpression tumor-bearing mice were used therapeutic target treatment. expression positively related tissues. In vitro assays, directly regulated cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced vivo markedly decreased death rate by...
Abstract Circular RNAs (circRNAs) are RNA molecules frequently involved in tumorigenesis. This research study focuses on the relevance of hsa_circ_515 (circ_515) to non‐small cell lung cancer (NSCLC) progression and downstream targets involved. Differentially expressed circRNAs NSCLC were screened using a GSE158695 dataset. Circ_515 was overexpressed indicated poor outcomes patients with NSCLC. Knockdown circ_515 repressed proliferation invasiveness, while potentiated cycle arrest apoptosis...
Sphingosine kinase 2 (SphK2) as a conserved lipid has not been thoroughly elucidated in non-small cell lung cancer (NSCLC). The aim of the present study was to evaluate expression SphK2 NSCLC tissues and determine its correlation with clinicopathologic characteristics impact on patient prognosis. We assessed proliferating nuclear antigen (PCNA) (as proliferative index) by immunohistochemistry 180 patient's formalin-fixed paraffin-embedded tissue blocks. Relationship between PCNA various...
This study aimed to explore the circular RNA (circRNA/circ) profile engaged in non-small cell lung cancer (NSCLC) development and metastasis investigate potentially key carcinogenic circRNAs related NSCLC.CircRNA profiles between 10 NSCLC tissues adjacent five with lymph node (LNM) without LNM were detected by Arraystar Human circRNA Array followed bioinformatics. Circ_0008594 knockdown, circ_0004293 overexpression, circ_0003832 overexpression plasmids transfected into H23 H460 cells sort...
To explore the effectiveness of model based on non-negative matrix factorization (NMF), analyze tumor microenvironment and immune for evaluating prognosis lung adenocarcinoma, establish a risk model, screen independent prognostic factors.Downloading transcription data files clinical information adenocarcinoma from TCGA database GO database, R software was used to NMF cluster then survival analysis between groups, analysis, performed according result. construct models calculate scores....
Objective To investigate the expressions and clinical significance of Ki-67, p53, survivin in esophageal cancer precancerosis. Methods The proteins were detected by immunohistochemical staining 40 normal mucosa, 136 precancerosis (42 mild atypical hyperplasia, 43 moderate 51 severe hyperplasia), 68 tissues. The correlation three expressed carcinoma tissues was analyzed. Results The positive expression rate Ki-67 0 (0/40)for epithelium, 35.7% (15/42) for dysplasia, 51.2% (22/43)...
Esophageal cancer is one of the most common alimentary malignancy.Although drugs and radiation treatments for esophageal are constantly improved,surgical resection still recognized as effective treatment method at present.With continuous development surgical techniques,minimally invasive surgery technology has bcen performed home abroad,for purpose reducing complications or mortality improving post-operative quality life.Minimally indications,surgical procedure selection,complications...