A5116691922- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Neuroscience and Neural Engineering
- Planarian Biology and Electrostimulation
- RNA modifications and cancer
- interferon and immune responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Metabolomics and Mass Spectrometry Studies
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Genetic Mapping and Diversity in Plants and Animals
- Immune cells in cancer
- Inflammasome and immune disorders
- Chemokine receptors and signaling
- Cancer, Hypoxia, and Metabolism
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Viral Infections and Immunology Research
- Phytochemistry and Biological Activities
- Synthesis and biological activity
- bioluminescence and chemiluminescence research
- Plant Toxicity and Pharmacological Properties
- Ferroptosis and cancer prognosis
- Insect symbiosis and bacterial influences
Jilin University
2015-2025
Xinjiang Production and Construction Corps
2023-2025
Tarim University
2021-2025
Union Hospital
2025
Sun Yat-sen University
2024
Fifth Affiliated Hospital of Sun Yat-sen University
2024
Hunan Rice Research Institute
2012-2023
Beijing University of Chemical Technology
2023
Hunan Academy of Agricultural Sciences
2023
State Intellectual Property Office
2023
Arthropod phenoloxidase (PO) generates quinones and other toxic compounds to sequester kill pathogens during innate immune responses. It is also involved in wound healing physiological processes. Insect PO activated from its inactive precursor, prophenoloxidase (PPO), by specific proteolysis via a serine protease cascade. Here, we report the crystal structure of PPO lepidopteran insect at resolution 1.97 A, which initial for type 3 copper protein family. Manduca sexta heterodimer consisting...
To evaluate the effect of p53 on pyroptosis and its inhibitory role tumor growth in non-small-cell lung cancer (NSCLC). The correlation was determined tissues NSCLC patients. pyroptotic level detected A549 cells to clarify pyroptosis. overexpression tumor-bearing mice were used therapeutic target treatment. expression positively related tissues. In vitro assays, directly regulated cells. p53-specific knockdown blocked lipopolysaccharide- (LPS-) induced vivo markedly decreased death rate by...
Abstract Coxsackievirus A6 (CVA6) has recently emerged as a major cause of hand, foot and mouth disease in children worldwide but no vaccine is available against CVA6 infections. Here, we demonstrate the isolation two forms stable particles-procapsid A-particle-with excellent biochemical stability natural antigenicity to serve candidates. Despite presence (in A-particle) or absence procapsid) capsid-RNA interactions, particles have essentially identical atomic capsid structures resembling...
// Jiu-Ming Zou 1, * , Jian Qin Yong-Chao Li 1 Yu Wang Dong Shu Chao Luo Shan-Shan Gang Chi Fang Guo Gui-Mei Zhang Zuo-Hua Feng Department of Biochemistry and Molecular Biology, School Basic Medicine, Tongji Medical College, Huazhong University Science Technology, Wuhan 430030, The People’s Republic China These authors have contributed equally to this work Correspondence to: Feng, email: fengzhg_tj@163.com Li, yongchaolee@outlook.com Keywords: IL-35, neutrophils, inflammation, tumor,...
Circular RNAs (circRNAs) are a class of non-coding broadly expressed in cells various species. However, the molecular mechanisms that link circRNAs with colorectal cancer (CRC) not well understood. In present study, we attempted to provide novel basis for targeted therapy CRC from aspect circRNA-microRNA (miRNA)-mRNA interaction.We investigated expression five paired tissues and adjacent non-tumor by microarray analysis. Differentially were identified between non-cancerous matched tissues....
The RAS/MAPK pathway is a major driver of oncogenesis and dysregulated in approximately 30% human cancers, primarily by mutations the BRAF or RAS genes. extracellular-signal-regulated kinases (ERK1 ERK2) serve as central nodes within this pathway. feasibility targeting has been demonstrated clinical responses observed through use MEK inhibitors V600E/K metastatic melanoma; however, resistance frequently develops. Importantly, ERK1/2 inhibition may have utility overcoming acquired to RAF...
The CXC chemokines belong to a family which includes 17 different members. Accumulating evidence suggests that regulate tumor cell proliferation, invasion, and metastasis in various types of cancers by influencing the microenvironment. expression profiles specific function each chemokine head neck squamous carcinoma (HNSCC) are not yet clarified. In our work, we analyzed altered expression, interaction network, clinical data patients with HNSCC using following: Oncomine dataset, cBioPortal,...
Human interleukin-18 (hIL-18) is a cytokine that plays an important role in inflammation and host defense against microbes. Its activity regulated vivo by naturally occurring antagonist, the human IL-18-binding protein (IL-18BP). Functional homologs of IL-18BP are encoded all orthopoxviruses, including variola virus, causative agent smallpox. They contribute to virulence suppressing IL-18-mediated immune responses. Here, we describe 2.0-A resolution crystal structure orthopoxvirus IL-18BP,...
Abstract: MicroRNAs (miRNAs) have emerged as important regulators of cancer-cell biological processes. Previous studies shown that miR-766 plays an role in a variety processes various human cancers. However, the underlying mechanism colorectal cancer (CRC) cells remains unclear. In this study, we investigated miR-766's CRC cell proliferation. Polymerase chain reaction results showed expression was significantly upregulated tissues and cells. Ectopic promoted growth anchorage-independent...
Abstract Non-small cell lung cancer (NSCLC), one of the most common causes cancer-related death, is a worldwide public health problem. MicroRNAs (miRNAs) have recently been identified as novel class regulators carcinogenesis and tumor progression, including miRNAs associated with NSCLC. This study aimed to explore role miR-522 in NSCLC mechanisms underlying this role. We report here that expression was significantly increased both human tissues lines. Furthermore, an MTT assay,...
Background/Aims: Since the combined actions of lncRNAs and miRNAs have been considered to be involved in occurrence development various neoplasms, main purpose this study was discover whether how lncRNA H19 miR-194 influenced epithelial-mesenchymal transition (EMT) process colorectal adenocarcinoma (CRA). Methods: Totally 214 pairs CRA adjacent normal tissues were collected, 5 human cell lines (i.e. HCT116, HT-29, RKO SW280 Lovo) purchased. Quantitative reverse transcription-polymerase chain...
Ovarian cancer (OV) is associated with the highest mortality rate among gynecological cancers, largely due to late diagnosis and chemoresistance. The identification of novel diagnostic markers therapeutic targets crucial. Caldesmon 1 (CALD1), a cytoskeleton-regulating protein, has been implicated in various cancers. This study aims investigate expression functional significance CALD1 OV, focusing on its potential impact cell invasion metastasis. We analyzed using Cancer Genome Atlas (TCGA)...
The loss of oligodendrocytes in a lesion the central nervous system causes demyelination and therefore impairs axon function survival. Transplantation neural stem cell-derived oligodendrocyte precursor cells (NSC-OPCs) results increased formation enhanced remyelination. directional migration grafted to target can promote establishment functional reconnection myelination process regeneration. Endogenous electric fields (EFs) that were detected development regulate cell migration.NSCs isolated...
In peripheral nervous systems, Schwann cells wrap around axons of motor and sensory neurons to form the myelin sheath. Following spinal cord injury, regenerate migrate lesion are involved in regeneration process. Transplantation into injured neural tissue results enhanced axonal regeneration. Effective directional migration is critical this study, we report that anodally an applied electric field (EF). The directedness displacement anodal increased significantly when strength EF from 50...
The current belief is that Randall's plaques (RP) constitute a nidus for the formation of idiopathic calcium oxalate stones, but upstream events in RP remain unclear. present study aimed to investigate whether shares similarities with biomineralization and illustrate potential role played by lncRNA MALAT1 osteogenic differentiation human renal interstitial fibroblasts (hRIFs).Biomineralization expression were assessed RP, hRIFs isolated induced under conditions further experiments....
Abstract We previously bred a salt tolerant wheat cv. SR3 with bread JN177 as the parent via asymmetric somatic hybridization and found that tolerance is partially attributed to superior photosynthesis capacity. Here, we compared proteomes of two cultivars unravel basis In maps dimensional difference gel electrophoresis (2D-DIGE), there were 26 differentially expressed proteins (DEPs), including 18 cultivar-based 8 stress-responsive ones. 21 DEPs identified classified into four categories,...
// Jing Luo 1, * , Xin-Xia Feng 2, Chao 1 Yu Wang Dong Li Shu Shan-Shan Jian Qin Yong-Chao Jiu-Ming Zou De-An Tian 2 Gui-Mei Zhang Zuo-Hua Department of Biochemistry and Molecular Biology, School Basic Medicine, Wuhan 430030, People's Republic China Tongji Hospital, Medical College, Huazhong University Science Technology, These authors contributed equally to this work Correspondence to: Feng, email: fengzhg_tj@163.com Zhang, zhanggm58@163.com Keywords: neutrophils, recruitment, metastases,...
Abstract Cluster of differentiation 47 (CD47) is an important innate immune checkpoint that empowers tumors to send “don't eat me” signals, leading escape. CD47 monoclonal antibodies have achieved remarkable therapeutic success in hematological malignancies. However, their efficacy solid limited, mainly because immunosuppression the tumor microenvironment. In addition, hematotoxicity severely hinders clinical translation antibodies. Here, a novel genetically programmed nanovesicle,...