A5021411903- Circadian rhythm and melatonin
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Spaceflight effects on biology
- Neuroscience of respiration and sleep
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Sleep and Wakefulness Research
- Heme Oxygenase-1 and Carbon Monoxide
- Digestive system and related health
- Mitochondrial Function and Pathology
- Dermatological and Skeletal Disorders
- Stress Responses and Cortisol
- Dental Health and Care Utilization
- Kidney Stones and Urolithiasis Treatments
- Cancer-related molecular mechanisms research
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Dietary Effects on Health
Sun Yat-sen University
2016-2025
Hospital of Stomatology, Sun Yat-sen University
2013-2025
Nanjing General Hospital of Nanjing Military Command
2016-2025
Nanjing University
2016-2025
Nanjing Medical University
2018-2025
Stomatology Hospital
2013-2024
Louisiana State University Health Sciences Center Shreveport
2024
Central South University
2017-2024
Central South University of Forestry and Technology
2024
Peking University Shenzhen Hospital
2024
Dental pulp/dentine complex regeneration is indispensable to the construction of biotissue-engineered tooth roots and represents a promising approach therapy for irreversible pulpitis. We used tissue-engineering method based on odontogenic stem cells design three-dimensional (3D) scaffold-free stem-cell sheet-derived pellet (CSDP) with necessary physical biological properties. Stem were isolated identified from root apical papilla (SCAPs)-based CSDPs then fabricated examined. Compact cell...
The current study was designed to investigate the effect of madecassoside, major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism action. An oral administration madecassoside (6, 12, 24 mg/kg) facilitated closure a time-dependent manner reached peak effect, nearly completely closure, day 20 group receiving highest dose mg/kg madecassoside. Further histopathological analysis revealed that alleviated infiltration inflammatory cells as well enhanced...
Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in development AD. It now generally accepted that massive death due to apoptosis common characteristic brains patients suffering from diseases, apoptotic cell has been found neurons glial cells Melatonin secretory product pineal gland; melatonin potent antioxidant free radical...
Mutations in the parkin gene are currently thought to be most common cause of recessive familial Parkinsonism. Parkin functions as an E3 ligase regulate protein turnover, and its function mitochondrial quality control has been reported recently. Overexpression found prevent neuronal degeneration under various conditions both vivo vitro. Here, we generated a transgenic mouse model which expression wild type was driven by neuron-specific enolase (NSE) promoter. We that young old mice exhibited...
Although microRNA-155 (miR-155) is known to play an important role in many cancers, its expression and function oral squamous cell carcinoma (OSCC) was not fully understood. Thus, the present study, we investigated of miR-155 also this miR plays OSCC. We used OSCC line (CAL27) paired tumor non-tumor tissue samples from patients with order detect miR-155. Cell proliferation, migration invasion assays were then undertaken determine effect on biological behavior CAL27 cells following transient...
Chlorogenic acid (CGA) has many biological properties, including antibacterial, antioxidant and anti‐inflammatory is one of the most abundant phenolic acids available in human diet. The aim this study was to investigate effects CGA on regulation gut microbiota, levels free amino 5-hydroxytryptamine (5-HT, serotonin). Ninety-six healthy growing pigs were randomly assigned two treatment groups: Ctrl group (control group, standard feed) [standard feed plus 0.05% 3-caffeoylquinic (3-CQA)] for 60...
Lymph node metastasis in patients with urinary bladder cancer (UBC) is always associated poor prognosis and the determinant for tumor staging development of treatment regimens; however, its underlying mechanisms remain to be studied. Immunohistochemical staining sections from 62 UBC was performed using CCR7, D2-40 CD34 antibodies. We showed that increased CCR7 expression significantly positive lymph status (P=0.008), pT3-T4 stage (P=0.015), grade (P=0.010) worse overall survival (OS,...
Dental caries among preschool children were prevalent worldwide and had a significant impact on their families. Understanding its prevalence risk factors helps to optimize the delivery of oral health care target population promote ultimately. This cross-sectional study aimed examine dental associated 3- 5-year-old in Huizhou, Guangdong Province, China.
Background:Aging is a highly complex process that affects various tissues and systems in the body. Senescent changes are relatively more prevalent severe postmitotic cells. Mitochondria play an important role aging process. Recently, cell cultures have been widely used as vitro model to study aging. The present was designed investigate mitochondrial dysfunction associated with long-term culture system.Material/Methods:Rat hippocampal neurons were maintained serum-free medium for 30 days...
Melatonin mediates a variety of biological processes ranging from the control circadian rhythms to immune regulation. also influences bone formation and osteointegration dental implants. However, effects melatonin on dentine have not been examined. This study investigated proliferation differentiation rat papilla cells (rDPCs) in vitro vivo. We found that (0, 10(-12) , 10(-10) ,10(-8) m) induced dose-dependent reduction rDPCs proliferation, increased alkaline phosphatase (ALP) activity,...
Chronic use of opioid analgesics has been hindered by the development addiction and tolerance. We have reported that curcumin, a natural flavonoid from rhizome <i>Curcuma longa,</i> attenuated tolerance, although underlying mechanism remains unclear. In this study, we tested hypothesis curcumin may inhibit Ca<sup>2+</sup>/calmodulin-dependent protein kinase II <i>α</i> (CaMKII<i>α</i>), previously proposed to be critical for tolerance dependence. used state-of-the-art polymeric formulation...
The distinct characteristics of γδ T cells determine their vital roles in the formation local immune responses and contribute to tissue homeostasis. However, heterogeneity across tissues remains unclear. By combining transcriptional chromatin analyses with a truly unbiased fashion, we constructed single-cell transcriptome accessibility landscape mouse lymph, spleen, thymus. We also revealed T1 T17 these inferred potential regulatory mechanisms. In thymus, reconstructed developmental...
Orofacial inflammation leads to transcriptional alterations in trigeminal ganglion (TG) neurons. However, diverse and regulatory mechanisms following orofacial inflammatory pain different types of TG neurons remain unclear. Here, was induced by injection complete Freund’s adjuvant (CFA) mice. After 7 days, we performed single-cell RNA-sequencing on cells mice from control treatment groups. We identified primary sensory neurons, Schwann cells, satellite glial oligodendrocyte-like immune...
Satellite glial cells (SGCs) play an important role in regulating the function of trigeminal ganglion (TG) neurons. Multiple mediators are involved bidirectional communication between SGCs and neurons different physiological pathological states. However, molecular insights into transcript characteristics limited. Moreover, little is known about heterogeneity TG, a more in-depth understanding interactions neuron subtypes needed. Here we show single-cell RNA sequencing (scRNA-seq) profile TG...
Odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs) is crucial for continued root development and dentin formation in immature teeth with periodontitis (AP). Fat mass obesity-associated protein (FTO) has been reported to regulate bone regeneration osteogenic profoundly. However, effect FTO on hSCAPs remains unknown. This study aimed identify potential function hSCAPs’ odontoblastic under normal inflammatory conditions investigate its underlying mechanism...