A5101712896- Food composition and properties
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Microbial Metabolites in Food Biotechnology
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Polysaccharides Composition and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- interferon and immune responses
- Cardiovascular Health and Risk Factors
- Aortic aneurysm repair treatments
- Pancreatic and Hepatic Oncology Research
- Diabetes Management and Education
- Biofuel production and bioconversion
- Phytase and its Applications
- MRI in cancer diagnosis
- GABA and Rice Research
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
Army Medical University
2021-2025
Yangzhou University
2017-2025
Daping Hospital
2025
Jilin University
2015-2024
Union Hospital
2016-2024
Southwest Hospital
2021-2024
Wuhan Center for Disease Control and Prevention
2018-2023
Union Hospital
2023
Jilin Medical University
2023
First Hospital of Shanxi Medical University
2023
We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over drafts 2002. Tested against a nonredundant collection 19,079 full-length cDNAs, 97.7% genes are aligned, without fragmentation, to mapped super-scaffolds one other genome. introduce gene identification procedure plants that does not rely on similarity known remove erroneous predictions resulting from transposable elements....
Pancreatic cancer tends to be highly resistant current therapy and remains one of the great challenges in biomedicine with very low 5-year survival rates. Here, we report that zalcitabine, an antiviral drug for human immunodeficiency virus infection, can suppress growth primary immortalized pancreatic cells through induction ferroptosis, iron-dependent form regulated cell death. Mechanically, this effect relies on zalcitabine-induced mitochondrial DNA stress, which activates...
Ferroptosis is a type of iron-dependent regulated cell death caused by the disruption that occurs when oxidative stress and antioxidant defenses interact, then driven lipid peroxidation subsequent plasma membrane ruptures. The regulation ferroptosis involves many factors, including crosstalk between subcellular organelles, such as mitochondria, endoplasmic reticulum (ER), lysosomes, droplets, peroxisomes. Here, we show ER protein STING1 (also known STING or TMEM173) promotes in human...
Macroautophagy (hereafter "autophagy") is a membrane-mediated biological process that involves engulfing and delivering cytoplasmic components to lysosomes for degradation. In addition autophagy's pro-survival effect during nutrient starvation, excessive activation of autophagy machinery can also cause regulated cell death, especially iron-dependent ferroptosis. Here, we report key role TMEM164 (transmembrane protein 164) in selectively mediating ATG5 (autophagy related 5)-dependent...
Abstract Ferroptosis is a type of lipid peroxidation-dependent cell death that emerging as therapeutic target for cancer. However, the mechanisms ferroptosis during generation and detoxification peroxidation products remain rather poorly defined. Here, we report an unexpected role eukaryotic translation initiation factor EIF4E determinant ferroptotic sensitivity by controlling peroxidation. A drug screening identified 4EGI-1 4E1RCat (previously known EIF4E-EIF4G1 interaction inhibitors)...
The chemoresistance of colon cancer to oxaliplatin (L-OHP) indicates poor prognosis. Long non-coding RNA (lncRNA) KCNQ1OT1 (KCNQ1 opposite strand/antisense transcript 1) has been shown participate in the tumorigenesis several types cancers. However, little is known about role and prognosis cancer.Quantitative-PCR Western blot were used measure expression profiles KCNQ1OT1, miR-34a, Atg4B tissues cells. Cell viability assay flow cytometry examine their effects on cell proliferation death....
Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive pancreatic ductal adenocarcinoma (PDAC). Design screened 429 kinase inhibitors blocking IFNG-induced checkpoint (indoleamine 2,3-dioxygenase 1 (IDO1) and CD274) expression human PDAC cell line. evaluated ability of cyclin-dependent (CDK) inhibitor dinaciclib to block IDO1 CD274 24 mouse...
Background & AimsPancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis a type of lipid peroxidation-dependent necrosis, which negatively regulated glutathione peroxidase 4. We studied how trypsin, serine protease secreted pancreatic cells, affects the contribution ferroptosis to triggering pancreatitis.MethodsIn vitro, mouse line 266-6 primary cells were used investigate effect exogenous trypsin on sensitivity. Short hairpin RNAs designed silence gene...