A5101866271- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Image Retrieval and Classification Techniques
- Cancer Immunotherapy and Biomarkers
- Heat shock proteins research
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Medical Image Segmentation Techniques
- Angiogenesis and VEGF in Cancer
- Advanced Image and Video Retrieval Techniques
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Image and Object Detection Techniques
- Immune Response and Inflammation
- Chemokine receptors and signaling
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Endometriosis Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Ubiquitin and proteasome pathways
Hebei University
2024
Institute of New Materials
2023-2024
Nanchang Hangkong University
2009-2024
First Affiliated Hospital of Jinan University
2023-2024
First Affiliated Hospital of Kunming Medical University
2022
Kunming Medical University
2022
Shenzhen Third People’s Hospital
2022
Huazhong University of Science and Technology
2009-2021
Wuhan University
2016
Laboratoire de Biochimie
2008
Abstract IL-17 is a pivotal proinflammatory molecule in asthmatics. However, the cellular source of asthma has not been identified to date. In this study, we report that macrophages rather than Th17 cells are main producer allergic inflammation related asthma. After OVA challenge mouse model mimicking asthma, increased IL-17+ lung were mainly CD11b+F4/80+ macrophages, instead T or others. Importantly, alveolar (AMs), but interstitial significantly after allergen challenge. The increase AMs...
The regulation of HIF-1alpha is considered to be realized by pVHL-mediated ubiquitin-26S proteasome pathway at a post-transcriptional level. discovery class small noncoding RNAs, called microRNAs, implies alternative mechanism HIF-1alpha. Here, we show that miR-20b plays an important role in fine-tuning the adaptation tumor cells oxygen concentration. inhibition increased protein levels and VEGF normoxic cells; increase hypoxic cells, nevertheless, decreased VEGF. By using luciferase...
Neutrophils are known to have antitumor potential. However, in recent years the tumor-promoting effect of neutrophils has been well demonstrated. So far, it remains unclear what causes conversion neutrophil function from tumor suppressive promoting. In this article, we report that murine occurs bone marrow, and IL-6 cooperation with G-CSF is required for conversion. cooperated modulate altering activation potential signaling pathways neutrophils, especially STAT3. Costimulation induced a...
Abstract T cell Ig mucin 3 (Tim-3) has been found to play an important role in Th1-mediated auto- and alloimmune responses, but the function of soluble form Tim-3 (sTim-3) remains be elucidated. In this study, we report inhibitory effect sTim-3 on cell-mediated immune response. mRNA was found, among different tissues organs, only splenic cells, activation splenocytes resulted up-regulated production both protein. We constructed a eukaryotic expression plasmid, psTim-3, which expresses...
Abstract The negative signal provided by interactions of programmed death-1 (PD-1) and its ligands, costimulatory molecules PD-L1 (also B7-H1) PD-L2 B7-DC), is involved in the mechanisms tumor immune evasion. In this study, we found that was also evasion immunotherapy. When used different doses a constructed eukaryotic expression plasmid, pSLC, which expresses functional murine secondary lymphoid tissue chemokine (SLC, CCL21), to treat BALB/c mice inoculated with H22 hepatoma cells,...
// Jiu-Ming Zou 1, * , Jian Qin Yong-Chao Li 1 Yu Wang Dong Shu Chao Luo Shan-Shan Gang Chi Fang Guo Gui-Mei Zhang Zuo-Hua Feng Department of Biochemistry and Molecular Biology, School Basic Medicine, Tongji Medical College, Huazhong University Science Technology, Wuhan 430030, The People’s Republic China These authors have contributed equally to this work Correspondence to: Feng, email: fengzhg_tj@163.com Li, yongchaolee@outlook.com Keywords: IL-35, neutrophils, inflammation, tumor,...
Abstract Pregnant women have both the local immune tolerance at maternal-fetal interface and systemic defense against pathogens. To date, regardless of extensive investigation on tolerance, maintenance in pregnant still remains poorly understood. In present study, we demonstrate that immunoregulatory molecule T cell Ig mucin domain (Tim)-3 plays important roles innate adaptive immunity human pregnancy. During pregnancy, Tim-3 is strikingly up-regulated peripheral blood women, most by...
Abstract Many tumor immunotherapy efforts are focused on the generation of strong T‐cell response against antigens. However, does not always coincide with rejection, for which upregulated expression immunoinhibitory molecules may be responsible. In this study, treatment heat shock protein 70 (HSP70) vaccine induced an infiltration T cells into site as well IFN‐γ and IL‐2, delayed lung metastases tumor, but progression nonetheless occur finally. We demonstrated that B7‐H1 expressed by...
// Rui Sun 1 , Jing Luo Dong Li Yu Shu Chao Shan-Shan Wang Jian Qin Gui-Mei Zhang Zuo-Hua Feng Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University Science & Technology, Wuhan, The People's Republic China Correspondence: Feng, email: Zhang, Keywords : neutrophils; protumor potential; priming; cytokines; NK cells Received May 17, 2014 Accepted July 8, Published 9, Abstract In tumor-bearing state, the function neutrophils is converted from...
Bio-based microcellulose/polymer composites are widely used in automotive interiors for their lightweight, environmentally friendly, and recyclable advantages, but applications limited due to the difficulty of dispersion matrix flammability. In this paper, we proposed integrated functional modification microcellulose with compatibility flame retardancy, then modified polypropylene high strength, thermal stability, retardancy were successfully prepared by extrusion–injection molding. Fourier...
Abstract Purpose: The use of costimulatory molecules targeting distinct T-cell signaling pathways has provided a means for triggering and enhancing antitumor immunity; however, it is still not fully understood what types are suitable the combination in tumor therapy. Our purpose this study to establish an effective immune approach by using molecule 4-1BBL with soluble PD-1. Experimental Design: murine H22 hepatocarcinoma served as ectopic model. Local gene transfer was done injection naked...
Abstract Condylomata acuminata derived from the infection of human papillomavirus is a common sexually transmitted disease. Although T cell-mediated cellular immunity considered as main arm against such infection, regulation cell immune responses in genital condylomata unclear to date. In this study, we analyzed FOXP3+ regulatory cells patients. The results show that with suppressive function accumulated large warts. Consistently, immunosuppressive milieu warts was characterized by high...
Abstract Evidence accumulated in recent years has revealed that neutrophils are involved the initial establishment of endometriosis, which is well-known as a chronic inflammatory disease. So far, why and how promote formation early endometriosis still unclear. In this study, using mouse model we demonstrated mice (EMs mice) had significantly increased number peritoneal fluids lesions, levels granulocyte colony-stimulating factor (G-CSF) IL-6 serum compared to control group. uterine fragments...
// Yong-Chao Li 1, * , Jiu-Ming Zou Chao Luo 1 Yu Shu Jing Jian Qin Wang Dong Shan-Shan Gang Chi Fang Guo Gui-Mei Zhang Zuo-Hua Feng Department of Biochemistry and Molecular Biology, School Basic Medicine, Tongji Medical College, Huazhong University Science Technology, Wuhan 430030, The People's Republic China These authors contributed equally to this work Correspondence to: Zhang, email: zhanggm58@163.com Luo, luoc2012@sina.com Keywords: circulating tumor cells (CTCs), disseminated...