A5100767849- COVID-19 Clinical Research Studies
- Gastrointestinal motility and disorders
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Gut microbiota and health
- COVID-19 diagnosis using AI
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Congenital gastrointestinal and neural anomalies
- Asthma and respiratory diseases
- Clostridium difficile and Clostridium perfringens research
- Biosensors and Analytical Detection
- COVID-19 and Mental Health
- SARS-CoV-2 detection and testing
- Dermatology and Skin Diseases
- Infant Health and Development
- Gastroesophageal reflux and treatments
- Hematological disorders and diagnostics
- Healthcare professionals’ stress and burnout
- Advanced Biosensing Techniques and Applications
- Eosinophilic Esophagitis
- Machine Learning in Healthcare
- Dermatological and COVID-19 studies
- Health, psychology, and well-being
- Therapeutic Uses of Natural Elements
Affiliated Hospital of Nantong University
2025
Nantong University
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Beijing VDJBio (China)
2025
Union Hospital
2016-2024
Huazhong University of Science and Technology
2016-2024
Lanzhou University
2020-2024
First Hospital of Lanzhou University
2020-2024
Chengdu Third People's Hospital
2021-2024
Zhejiang University
2024
Abstract Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies shown that some bat SARSr-CoVs potential to infect humans 5–7 Here we report identification and characterization new coronavirus (2019-nCoV), which caused an epidemic Wuhan, China. The epidemic, started on 12 December 2019, had 2,794 laboratory-confirmed infections...
The study analysed healthcare workers' (HCWs) knowledge, practices, and attitudes regarding coronavirus disease 2019 (COVID-19). A cross-sectional survey was conducted from February 4th to 8th, 2020, involving a total of 1357 HCWs across 10 hospitals in Henan, China. Of those surveyed, 89% had sufficient knowledge COVID-19, more than 85% feared self-infection with the virus, 89.7% followed correct practices COVID-19. In addition level, some risk factors including work experience job category...
Abstract IL-17 is a pivotal proinflammatory molecule in asthmatics. However, the cellular source of asthma has not been identified to date. In this study, we report that macrophages rather than Th17 cells are main producer allergic inflammation related asthma. After OVA challenge mouse model mimicking asthma, increased IL-17+ lung were mainly CD11b+F4/80+ macrophages, instead T or others. Importantly, alveolar (AMs), but interstitial significantly after allergen challenge. The increase AMs...
Abstract Background and Aims The aims of this study were to investigate the proportion clinical irritable bowel syndrome (IBS) at a tertiary hospital in China, compare Rome III IV criteria with regard IBS diagnosis, describe agreement between criteria, identify differences IV‐positive ‐negative patients. Methods A cross‐sectional survey was performed among outpatients gastrointestinal (GI) department hospital. patients categorized as having using criteria. Results In total, 1,376 (91.7%)...
Background: Although the prevalence of allergic asthma increased quickly in past decade, diagnostic criteria have not been well established. The aim present study was to explore whether stem cell factor (SCF), B cell‐activating (BAFF), and cytokines interleukin (IL)‐17 IL‐31 are usable parameters for diagnosis asthmatics. Methods: Blood samples were collected from patients with asthma, control patients, healthy subjects. serum concentrations SCF, BAFF, IL‐17, measured by enzyme‐linked...
Abstract Background and Aim Dynamic changes of immunocyte subsets inflammatory profiles in coronavirus disease 2019 (COVID‐19) patients with gastrointestinal symptoms were undetermined. Methods A single‐center retrospective analysis 409 severe, hospitalized COVID‐19 from 20 January to 29 February 2020 was performed. The longitudinal characteristics immune cytokines with/without diarrhea analyzed. relations immuno‐inflammatory factors illness course clinical outcomes further explored. Results...
Abstract Objectives We aimed to identify high-risk factors for disease progression and fatality coronavirus 2019 (COVID-19) patients. Methods enrolled 2433 COVID-19 patients used LASSO regression multivariable cause-specific Cox proportional hazard models the risk fatality. Results The median time from mild-to-moderate, moderate-to-severe, severe-to-critical, critical-to-death were 3.0 (interquartile range: 1.8–5.5), (1.0–7.0), (1.0–8.0), 6.5 (4.0–16.3) days, respectively. Among 1,758 mild...
Abstract Background and aims Hepatic sinusoidal obstruction syndrome (HSOS) is caused by toxic injury, such as pyrrolizidine alkaloids, to the liver endothelial cells, gut microbiota may be involved. However, specific role underlying mechanism of in HSOS unknown. Methods model was established gavage monocrotaline (MCT) rats. Fecal transplantation (FMT) with HSOS-derived or healthy flora also conducted validate microflora MCT-induced injury. The microbial 16 s rRNA analysis untargeted...
Triptolide is one of the main active components in Chinese herb Tripterygium wilfordii Hook F, which has been demonstrated to possess anti‑inflammatory properties. The aim this study was investigate effects triptolide on lipopolysaccharide (LPS)‑induced acute lung injury (ALI) mice and explore possible mechanisms. Mice were administered LPS intranasally induce injury, intraperitoneally 1 h prior challenge. Triptolide‑treated exhibited significantly reduced levels leukocytes, myeloperoxidase...
Diabetes is associated with an increased risk of cardiovascular disease. A decrease in the number and functionality endothelial progenitor cells (EPCs) leads to reduced repair development The aim present study was explore effect underlying mechanisms nuclear factor erythroid 2‑related 2 (Nrf2) on EPC dysfunction caused by diabetic mellitus. biological functions EPCs streptozotocin‑induced mice were evaluated, including migration, proliferation, angiogenesis secretion vascular growth (VEGF),...
It is currently unclear whether there a connection between Life's Essential 8 (LE8) and cardiovascular disease (CVD), as well mortality in people with nonalcoholic fatty liver (NAFLD). Our goal was to explore these relationships by examining data collected the National Health Nutrition Examination Survey (NHANES) from 2005 2018. We identified eligible participants NAFLD based on NHANES 2005-2018 data. CVD status acquired through self-reported information, using Death Index, were...
A total of 76 samples maize and its products were collected in 2022–2023 to estimate dietary exposure fumonisins (FBs) Dalian region, China. The identification FBs was performed by ultrahigh performance liquid chromatography coupled with mass spectrometry (UPLC-MS/MS). occurrences FB1, FB2, FB3, FB1 + FB2 FB3 89.5%, 77.6%, 61.8%, respectively, mean concentrations ranging from 140 1332 μg/kg. No individual cumulative health risks found due exposure, when considering the level. However, a...
Introduction Older adults are a high-risk group for hypertension, with specific characteristics regarding symptoms and treatment. Yishenjiangya granules (YJG), traditional Chinese medicinal decoction, widely used to reduce blood pressure improve clinical symptoms. This study aimed use metabolomics explore the effects underlying mechanisms of YJG in hypertension older adults. Methods The enrolled patients aged ≥65 years, systolic ≥140 mmHg and/or diastolic ≥90 sitting positions on different...