A5101583584- Carbohydrate Chemistry and Synthesis
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Beetle Biology and Toxicology Studies
- Metabolomics and Mass Spectrometry Studies
- Advanced optical system design
- biodegradable polymer synthesis and properties
- Polymer Nanocomposites and Properties
- Glycosylation and Glycoproteins Research
- Synthesis and bioactivity of alkaloids
- Traditional Chinese Medicine Studies
- Ideological and Political Education
- Fungal Biology and Applications
- Innovative Teaching Methods
- Delphi Technique in Research
- Diverse Academic Research Analysis
- Adaptive optics and wavefront sensing
- Eicosanoids and Hypertension Pharmacology
- Power Line Communications and Noise
- Traditional Chinese Medicine Analysis
- Proteoglycans and glycosaminoglycans research
- Silicone and Siloxane Chemistry
- Urban Transport and Accessibility
Peking University
2006-2025
Wuyi University
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Shandong University of Traditional Chinese Medicine
2024
Wuyi University
2021
Beijing Jishuitan Hospital
2020
East China Normal University
2017
Hunan University
2016
Peking University Shenzhen Hospital
2014
State Key Laboratory of Artificial Microstructure and Mesoscopic Physics
2013
Abstract The total synthesis of the tunicate metabolite mandelalide A and correction its originally assigned stereochemistry are reported. Key features convergent, fully stereocontrolled route include use a Prins cyclization for diastereoselective construction tetrahydropyran subunit, Rychnovsky–Bartlett preparation tetrahydrofuran moiety, Suzuki coupling, Horner–Wadsworth–Emmons macrocyclization, glycosylation to append L ‐rhamnose‐derived pyranoside.
Introduction Older adults are a high-risk group for hypertension, with specific characteristics regarding symptoms and treatment. Yishenjiangya granules (YJG), traditional Chinese medicinal decoction, widely used to reduce blood pressure improve clinical symptoms. This study aimed use metabolomics explore the effects underlying mechanisms of YJG in hypertension older adults. Methods The enrolled patients aged ≥65 years, systolic ≥140 mmHg and/or diastolic ≥90 sitting positions on different...
A second-generation formal synthesis of psymberin was successfully developed, incorporating several notable advancements. Central to this approach is a challenging Heck reaction, which effectively unites sterically demanding aryl moiety with terminal alkene, showcasing the method's robustness under these conditions. Additionally, construction isocoumarin scaffold accomplished through Pd-mediated cyclization, underscoring efficiency and precision key transformation. Notably, improved route De...
Abstract Highly reducing polyketide synthases (HR‐PKSs) produce structurally diverse polyketides (PKs). The PK diversity is constructed by a variety of factors, including the β‐keto processing, chain length, methylation pattern, and relative absolute configurations substituents. We examined stereochemical course processing for synthesis polyhydroxy PKs such as phialotides, phomenoic acid, ACR‐toxin. Heterologous expression HR‐PKS gene, trans‐acting enoylreductase truncated non‐ribosomal...
Sialosides incorporating substituted amides or amines at 9-position of sialic acid moiety have been synthesized and evaluated as CD22 inhibitors. Several derivatives exhibited inhibitory potency in sub- to low micromolar range (e. g., 8o, 9d, 9g, 9k showed IC50 values 0.40, 0.47, 0.24, 0.23 μM, respectively, for hCD22, while 8p, 8q, 9f, 1.70, 2.90, 4.10 mCD22). The most significant result was the strongly enhanced affinity 9g containing 9-(2′ 4′-hydroxy-4-biphenyl) methylamino substituents...
A convergent, stereocontrolled total synthesis of psymberin, an architecturally complex marine antitumor agent, has been achieved in 27 steps from the known aldehyde 8. Highlights this include a novel and efficient transannular Michael addition/lactone reduction sequence to construct highly substituted 2,6-trans-tetrahydropyran, diastereoselective IBr-induced iodocarbonate cyclization introduce C17 stereogenic center, Diels–Alder/aromatization reaction install aromatic ring.
Abstract The total synthesis of the tunicate metabolite mandelalide A and correction its originally assigned stereochemistry are reported. Key features convergent, fully stereocontrolled route include use a Prins cyclization for diastereoselective construction tetrahydropyran subunit, Rychnovsky–Bartlett preparation tetrahydrofuran moiety, Suzuki coupling, Horner–Wadsworth–Emmons macrocyclization, glycosylation to append L ‐rhamnose‐derived pyranoside.
Light emitting diode (LED) sources have been widely used for illumination. Optical design, especially freedom compact lens design is necessary to make LED applied in lighting industry, such as large-range interior and small-range condensed lighting. For different requirements, the size of target planes should be variable. In our paper we provide a method according energy conservation law Snell through establishing mapping between luminous flux emitted by Lambertian source certain area plane....
The asymmetric total synthesis of four diastereomers laingolide A was achieved, which led to the unambiguous assignment stereochemistry natural product. salient features convergent, fully stereocontrolled approach were a copper-catalysed stereospecific Kumada-type coupling, Julia-Kocienski olefination and an RCM/alkene migration sequence access desired macrocyclic enamide.
It is difficult to measure the junction temperature of every chip in light emitting diode (LED) integrated source by using common experimental methods. In this paper, a model simulate whole field sources face LED proposed. Fourier-based solution used solve heat equation three dimensions. The thermal programmed Matlab and has been validated finite element method simulations. comparison shows that relative error between these two models within 3.6%.
The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. longest linear sequence liquid-phase comprises 9 long steps from simple known starting materials, which led to unambiguous structural confirmation A.
The synthesis of uranium mononitride (UN) powders posed challenges due to potential impurities like oxygen (O) from UO2 precursors and fluorine (F) NH4HF2, which might persist within the UN lattice, consequently altering its inherent properties reactivity. In this work, we focused on evaluating integration F in nitriding process by ammonium fluoride compounds. By using first-principles calculations, impacts O crystal structure were studied, influence lattice was carefully elucidated....
采用扫描电子显微镜（SEM）、透射电子显微镜（TEM）、X射线衍射（XRD）等手段研究了苯乙烯-马来酸酐共聚物（SMA）、有机蒙脱土（OMMT）对尼龙6（PA6）/丙烯腈-丁二烯-苯乙烯（ABS）共混物体系聚集态结构及性能的影响.结果表明，SMA与OMMT的加入均可提高PA6/ABS共混物体系的强度及模量，但加入OMMT后共混物的韧性有所下降，而PA6/ABS/SMA共混物的韧性随SMA含量的增加呈上升趋势.SMA、OMMT对PA6/ABS共混体系都有细化ABS分散相的作用，随SMA加入量的增加，ABS分散相尺寸逐渐减小，分布趋于均匀；当OMMT加入量在4 phr以内时，对ABS分散相粒径影响不大，超过4 phr后，随着OMMT含量的增加，ABS分散相的尺寸逐渐减小.XRD与TEM的分析结果表明，对PA6/OMMT（100/5）共混物，OMMT主要以剥离形态分布，同时也存在少量OMMT聚集体； PA6/ABS/OMMT共混物中OMMT则基本以剥离形态选择分布在PA6基体相中.
Objective To compare the difference of facial soft-tissue changes extraction and nonextraction treatment by 3D scanning. Methods According to plans, patients were divided into two groups: groups—12 specimens group—10 specimens.We got patients' three-dimensional surfaces based on structured light techniques. We superimposited face soft tissue pre-and posttreatment Rapidforme 2006, reverse engineering sofeware, was software platform for data analysis. inferior 2/3 nine areas accordding...
Abstract Total synthesis of three different epimers as well another analogue Mandelalide A leads to the revision originally proposed structure.