A5100419651- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Chemical Synthesis and Analysis
- Carbohydrate Chemistry and Synthesis
- Asymmetric Synthesis and Catalysis
- Chemical synthesis and alkaloids
- Traditional and Medicinal Uses of Annonaceae
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
- Alkaloids: synthesis and pharmacology
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Natural product bioactivities and synthesis
- Synthesis and Biological Activity
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Synthesis and Catalytic Reactions
- Synthesis of heterocyclic compounds
- Microbial Inactivation Methods
- Cholinesterase and Neurodegenerative Diseases
- Plant biochemistry and biosynthesis
- Recommender Systems and Techniques
Nanjing Agricultural University
2023-2025
Peking University
2016-2025
Peking University People's Hospital
2025
Third Xiangya Hospital
2024
Central South University
2024
West China Hospital of Sichuan University
2007-2024
Southwest Jiaotong University
2021-2024
Sejong University
2024
Sichuan University
2012-2024
Air Force Medical University
2013-2024
The lack of floor plans is a critical reason behind the current sporadic availability indoor localization service. Service providers have to go through effort-intensive and time-consuming business negotiations with building operators, or hire dedicated personnel gather such data. In this paper, we propose Jigsaw, plan reconstruction system that leverages crowdsensed data from mobile users. It extracts position, size orientation information individual landmark objects images taken by also...
Reprogramming of somatic cells into induced pluripotent stem (iPSCs) by overexpression a defined set transcription factors requires epigenetic changes in pluripotency genes. Nuclear reprogramming is an inefficient process and the molecular mechanisms that reset state during iPSC generation are largely unknown. Here, we show downregulation nucleosome remodeling deacetylation (NuRD) complex required for efficient reprogramming. Overexpression Mbd3, subunit NuRD, inhibits induction iPSCs...
AbstractThe CUL4-ROC1 E3 ligase complex regulates genome stability, replication, and cell cycle progression. A novel WD40 domain-containing protein, L2DTL, PCNA were identified as proteins associated with CUL4/DDB1 complexes. Inactivation of CUL4A, PCNA, DDB1, or ROC1 induced p53 stabilization growth arrest. DDB1/CUL4A complexes found to physically interact tumor suppressor its regulator MDM2/HDM2. The isolated CUL4A display potent robust polyubiquitination activity towards this is dependent...
Abstract Background & Aims Largazole is a novel histone deacetylase ( HDAC ) inhibitor. This study investigated the effects of largazole against liver fibrosis. Methods The in vitro were examined using hepatic stellate cells HSC s). In vivo studied mouse fibrotic model induced by CC l 4 . Results augmented acetylation H3 (H3) and H4 (H4) HSCs. It directly inhibited activation HSCs owing to inhibitory activity as antifibrotic effect was significantly decreased with HDAC1, HDAC2 HDAC3...
Abstract The total synthesis of the tunicate metabolite mandelalide A and correction its originally assigned stereochemistry are reported. Key features convergent, fully stereocontrolled route include use a Prins cyclization for diastereoselective construction tetrahydropyran subunit, Rychnovsky–Bartlett preparation tetrahydrofuran moiety, Suzuki coupling, Horner–Wadsworth–Emmons macrocyclization, glycosylation to append L ‐rhamnose‐derived pyranoside.
UCS1025A is a fungal polyketide/alkaloid that displays strong inhibition of telomerase. The structures and related natural products are featured by tricyclic furopyrrolizidine connected to trans-decalin fragment. We mined the genome thermophilic fungus activated ucs gene cluster produce at high titer. Genetic biochemical analysis revealed PKS-NRPS assembly line activates 2S,3S-methylproline derived from l-isoleucine, followed Knoevenagel condensation construct pyrrolizidine moiety. Oxidation...
Social recommendation, which leverages social connections to construct Recommender Systems (RS), plays an important role in alleviating information overload. Recently, Graph Neural Networks (GNNs) have received increasing attention due their great capacity for graph data. Since data RS is essentially the structure of graphs, GNN-based flourishing. However, existing works lack in-depth thinking recommendations. These methods contain implicit assumptions that are not well analyzed practice. To...
ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTTotal Synthesis and Stereochemical Reassignment of BisebromoamideXuguang Gao†, Yuqing Liu‡, Shuqin Kwong‡, Zhengshuang Xu*†‡, Tao Ye*†‡View Author Information Laboratory Chemical Genomics, Peking University Shenzhen Graduate School, Town Shenzhen, Xili, Nanshan District, China, 518055, Department Applied Biology & Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Kong, China[email protected]; [email protected]†Peking School.‡The...
LSD1 is essential for the maintenance of pluripotency embryonic stem (ES) or carcinoma/teratocarcinoma (EC) cells. We have previously developed novel inhibitors that selectively inhibit ES/EC However, critical targets remain unclear. Here, we found interacts with histone deacetylase 1 (HDAC1) to regulate proliferation cells through acetylation H4 at lysine 16 (H4K16), which show a substrate HDAC1. The demethylase and HDAC1 activities were both inactivated if one them in complex was...
Total synthesis of four callyspongiolide stereoisomers led to unambiguous assignment relative and absolute stereochemistry the natural product. Key features convergent, fully stereocontrolled route include use Krische allylation, Kiyooka Aldol reaction, Kociénski–Julia olefination, Still–Gennari Yamaguchi macrocyclization, Sonogashira coupling reaction. Biological evaluation synthesized compounds against an array cancer cells revealed that macrolactone core played important role.
Abstract Nannocystin A, a structurally unique 21‐membered macrocyclic depsipeptide with low nanomolar inhibitory activity against elongation factor 1A, was synthesized according to strategy involving the vinylogous Mukaiyama aldol reaction, Sharpless epoxidation, olefin metathesis, Mitsunobu and palladium‐catalyzed intramolecular Suzuki coupling of highly complex cyclization substrate. The overall synthesis is efficient paves way for preparation analogues drug development efforts.
Abstract Heterotopic ossification (HO) comprises the abnormal formation of ectopic bone in extraskeletal soft tissue. The factors that initiate HO remain elusive. Herein, we found calcified apoptotic vesicles (apoVs) led to increased calcification and stiffness tendon extracellular matrix (ECM), which initiated M2 macrophage polarization progression. Specifically, single‐cell transcriptome analyses different stages revealed apoVs were primarily secreted by a PROCR + fibroblast population. In...
A convergent total synthesis of phorboxazole (1a), from the C(3–19), C(20–27) and C(33–46) fragments 5, 4 91, respectively, concentrating on stereocontrolled formation bonds at C(2–3), C(19–20) C(27–28), is described. Although a coupling reaction between macrolide ketone side chain substituted sulfone, C(27–28) was not successful, Wadsworth–Emmons olefination involving oxane methyl an oxazole produced 90 which next coupled to 91 leading C(20–46) unit 100. further 100 71c then led 105,...
A practical synthesis of (E)-1-stannylalk-1-enes containing a range oxygen and nitrogen functionality is highlighted, involving hydrostannylation followed by palladium-catalysed carbon–bromine bond cleavage reactions 1-bromoalkynes.
High levels of regio-, stereo- and enantio-selectivity are achieved in the asymmetric synthesis six-membered oxygen heterocycles via intramolecular C–H insertion reactions α-diazoketones catalysed by chiral rhodium(II) carboxylates.
A revised configurational assignment for the marine metabolite lagunamide is proposed and validated by total synthesis.
The structural groups of 2-oxindole and tricyclic 3a-hydroxy-hexahydropyrrolo-[2,3-b]indole (HO-HPI) are important pharmacophores. Chemical synthesis complex alkaloids containing a or HO-HPI moiety, especially the latter one, has been long-standing challenge. Herein, we characterized P450 enzyme AfnD, its homologue proteins, HmtT, ClpD, KtzM, LtzR, as cyclopeptide monooxygenases (cpOPMOs) that could introduce moiety into tryptophan-containing cyclopeptides in pH-dependent manner. A universal...
Lagunamide D is a structurally distinct 26-membered cytotoxic cyclic depsipeptide, originally isolated from marine cyanobacterium. It exhibits potent antiproliferative activity in the low nanomolar range against A549 human lung adenocarcinoma cells and HCT116 colon cancer cells. A significant challenge associated with lagunamide its propensity for intramolecular acyl migration, which leads to formation of contracted 24-membered analog, D′. This structural rearrangement complicates isolation,...
Purpose To evaluate and contrast the effectiveness safety of two conbercept treatment protocols—a three-dose treat-and-extend (3+T&E) regimen a pro re nata (3+PRN) regimen—in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).