A5101645999- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Ophthalmology and Visual Impairment Studies
- CNS Lymphoma Diagnosis and Treatment
- Ocular Oncology and Treatments
- Cerebral Venous Sinus Thrombosis
- Cytomegalovirus and herpesvirus research
- Long-Term Effects of COVID-19
- Photoreceptor and optogenetics research
- Parvovirus B19 Infection Studies
- RNA regulation and disease
- Infectious Diseases and Tuberculosis
- Child Abuse and Related Trauma
- Sarcoidosis and Beryllium Toxicity Research
- Digital Imaging for Blood Diseases
- Diabetes and associated disorders
- Corneal surgery and disorders
- Histiocytic Disorders and Treatments
- Retinopathy of Prematurity Studies
- Chronic Lymphocytic Leukemia Research
Shanghai First People's Hospital
2016-2025
Shanghai Jiao Tong University
2012-2024
Shanghai Eye Disease Prevention & Treatment Center
2020-2024
National Clinical Research
2023
University of Lusaka
2023
Center for Visual Communication (United States)
2023
Vitreous Retina Macula Consultants of New York
2013-2019
Manhattan Eye, Ear and Throat Hospital
2015-2019
Nanjing Medical University
2019
Nanjing University of Chinese Medicine
2019
Purpose. To describe the morphological characteristics and efficacy of OCTA in detecting CNV nAMD. We retrospectively reviewed 53 patients (86 eyes) with suspected secondary to wet AMD. All underwent a multimodal assessment for CNV. Two independent readers calculated sensitivity specificity compared FA. A qualitative analysis was also performed appearance Among 86 eyes patients, 52 were diagnosed as having based on FA imaging analysis. According FA, classified classic 28 eyes, predominantly...
To evaluate the multimodal imaging findings in retinal deep capillary ischemia (DCI).This was a retrospective review of 5 eyes 4 patients with sudden onset paracentral scotomas caused by DCI. Multimodal techniques, including color and red-free photographs, near-infrared reflectance, fluorescein angiography, spectral-domain optical coherence tomography, were performed all eyes, correlated microperimetry two eyes. Imaging DCI compared those cotton wool spot superficial (SCI).Unlike SCI,...
To assess the treatment response to mineralocorticoid antagonists in a pilot study of patients diagnosed with central serous chorioretinopathy using multimodal imaging.This retrospective observational case series included 23 eyes 14 treated by single physician (L.A.Y.) either spironolactone, eplerenone, or both consecutively over 12-month period. Choroidal thickness, macular and best-corrected visual acuity were measured compared baseline values. Twelve 11 demonstrated subretinal fluid...
Worldwide, polypoidal choroidal vasculopathy (PCV) is a common vision-threatening exudative maculopathy, and pigment epithelium detachment (PED) an important clinical characteristic. Thus, precise efficient PED segmentation necessary for PCV diagnosis treatment. We propose dual-stage learning framework via deep neural networks (DNN) automated in patients to avoid issues associated with manual (subjectivity, errors, high time consumption).The optical coherence tomography scans of fifty were...
To compare the clinical performance of 4 spectral-domain (SD) optical coherence tomography angiography (OCTA) systems: AngioVue™, AngioPlex™, Spectralis® OCTA, AngioScan, and 1 swept-source (SS) OCTA SS OCT Angio™.Twenty-seven undilated right eyes 27 participants underwent examination using five different systems respectively for both 3×3 6×6 mm2 scan pattern (Spectralis only). Image quality, including vessel valid visibility number motion artifacts, acquisition time were evaluated. Repeated...
To explore a segmentation algorithm based on deep learning to achieve accurate diagnosis and treatment of patients with retinal fluid.
To investigate the prevalence and associated factors of fundus tessellation in highly myopic children adolescents.A total 513 high myopes (spherical equivalent [SE] ≤ -5.0 D, 4-19 years age) without any advanced pathological lesions were enrolled. Fundus photographs choroidal thickness (ChT) data collected by SS-OCT. A novel grading approach was adopted to classify into four categories on colour photography, referring location divided an Early Treatment Diabetic Retinopathy Study grid...
Purpose To evaluate and contrast the effectiveness safety of two conbercept treatment protocols—a three-dose treat-and-extend (3+T&E) regimen a pro re nata (3+PRN) regimen—in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).
To evaluate the efficacy of MP-3 microperimeter biofeedback fixation training (MBFT) in vision rehabilitation low-vision patients affected by macular disease with central loss.Seventeen eyes (7 age-related degeneration, 10 myopic maculopathy) 17 were included this prospective, interventional study. The preferred retinal locus was determined comprehensive ophthalmoscopic fundus evaluation including photography, autofluorescence, optical coherence tomography, and microperimetry. consisted...
To measure the retinal thickness of posterior pole in healthy Chinese subjects using a analyzer and to compare thicknesses between different age, gender, refractive error groups.Between February 2002 September 2004, (age range, 21-50 years), underwent measurements visual acuity, error, intraocular pressure, with RTA, as well ophthalmoscopy slit lamp examinations. Eleven parameters were directly derived from reports RTA measurement. The average value each parameter was compared male female...
<b><i>Purpose:</i></b> To demonstrate the detection of choroidal neovascularization (CNV) in clinically diagnosed central serous chorioretinopathy (CSC) by optical coherence tomographic angiography (OCTA). <b><i>Methods:</i></b> Seventy-five eyes 70 patients were included. OCTA was performed on each patient. Two trained readers evaluated images independently to confirm diagnosis and identify CNV at level outer retina....
To investigate the distribution characteristics of lens power in highly myopic Chinese children and adolescents its association with age, axial length (AL), spherical equivalent (SE).Cross-sectional study.A total 459 (SE ≤-5 diopter [D]) aged 4-19 years were included study. Participants underwent a series ophthalmic examinations, which AL, cycloplegic refraction, Pentacam measurements. Lens was calculated using Bennett's formula described by SE. Multiple regression conducted to analyze...
Valsalva retinopathy and traumatic macular hole are common conditions, but secondary to is rarely reported. A 34-year-old healthy man suffered after doing push-up exercise. During his follow-up visits, the best-corrected visual acuity (BCVA) measurements, fundus examinations spectral-domain optical coherence tomography (SD-OCT) tests were performed. Three months later, premacular hemorrhage was noticeably absorbed with an improvement of acuity. SD-OCT showed a lamellar intact thickened...
AIM: To assess alterations in growth factors, inflammatory mediators, and cytokines associated with vitreous-retinal diseases vitreous humor from patients proliferative diabetic retinopathy (PDR), to identify potential new treatment targets strategies. METHODS: Control samples were collected macular hole, epiretinal membranes, or rhegmatogenous retinal detachments, PDR complications of PDR, who required pars plana vitrectomy. Specimens stored at −80℃ then investigated by Luminex multi-factor...
Purpose The present study analyzed the appearances of optical coherence tomography angiography (OCTA) in patients with central serous chorioretinopathy (CSC) based on fluorescein (FA) and indocyanine green (ICGA). Method In current case series, 54 eyes 50 diagnosed as CSC were evaluated retrospectively. OCTA, FA, ICGA performed each patient. Two trained observers examined OCTA images independently to confirm compare choriocapillary appearance that FA/ICGA. Also, leakage vessels perfusion...
Abstract Background To investigate the clinical effects of double-dose (4 mg) aflibercept treatment in neovascular age-related macular degeneration (nAMD), compared with standard-dose (2 treatment. Methods A total 108 eyes from 97 patients nAMD and received intravitreal 2 mg and/or 4 were retrospectively reviewed. The changes central thickness (CMT)/ pigmental epithelium detachment height recurrence rate exudation during 12-month follow-up between group group. Self-control comparisons switch...
To evaluate the morphology and functional recovery of retina after treatment idiopathic choroidal neovascularization using intravitreal injections bevacizumab in young adults.For this interventional case series, 20 eyes 19 patients with were treated multiple bevacizumab. Changes best-corrected visual acuity before at follow-up visits recorded. Structural changes evaluated optical coherence tomography assessed microperimetry.Twenty followed for 12 months their first injection. The underwent...
Objective The present study aimed to investigate the characteristics of macular telangiectasia type 1 (Mac tel 1) using spectral‐domain optical coherence tomography angiography (OCTA) and compare them with mild diabetic edema (DME), provide a new objective method for quick clinical diagnosis treatment. Methods A retrospective comparative analysis 9 Mac 1, 15 DME, normal eyes was performed fluorescein angiography, tomography, OCTA. morphological changes, retinal vessel density, nonperfused...
Retinitis pigmentosa (RP) is a monogenic disease characterized by irreversible degeneration of the retina. PRPF31, second most common causative gene autosomal dominant RP, frequently harbors copy number variations (CNVs), but underlying mechanism unclear. In this study, we summarized phenotypic and genotypic characteristics 18 RP families (F01-F18) with variants in PRPF31. The prevalence PRPF31 our cohort Chinese was 1.7% (18/1024). Seventeen different were detected, including eight novel...