A5101811219- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS drug development and treatment
- Mosquito-borne diseases and control
- Epilepsy research and treatment
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Liver Disease and Transplantation
- Retinal Imaging and Analysis
- Malaria Research and Control
- HIV/AIDS Research and Interventions
- Hepatitis Viruses Studies and Epidemiology
- Gastric Cancer Management and Outcomes
- Antifungal resistance and susceptibility
- Retinal Diseases and Treatments
- Herbal Medicine Research Studies
- Antimicrobial Peptides and Activities
- Blood transfusion and management
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Complement system in diseases
- Dialysis and Renal Disease Management
- Lower Extremity Biomechanics and Pathologies
- Gastrointestinal Tumor Research and Treatment
Second Xiangya Hospital of Central South University
2020-2025
Central South University
2020-2025
Chinese PLA General Hospital
2021-2024
Shanghai First People's Hospital
2024
Xiangya Hospital Central South University
2022-2024
Anhui Medical University
2019-2024
Shanghai Jiao Tong University
2022-2024
First Affiliated Hospital of Anhui Medical University
2019-2024
Jiangnan University
2024
Yangzhou University
2024
The aim of our study was to determine the outcomes liver transplant recipients receiving either lamivudine (LAM) monotherapy or LAM combined with low-dose intramuscular (IM) hepatitis B Immunoglobulin (HBIG) therapy. We performed a retrospective review medical records patients that had transplantation in single center for HBV-related diseases from December 1999 June 2004. A total 165 received (51 patients) prophylaxis (114 post-liver (LT) mean follow-up 20.13 months. Hepatitis relapsed 21...
To investigate the impact of pathway-based care on patients with cholelithiasis undergoing daytime cholecystectomy. Two hundred fifty-eight scheduled for cholecystectomy were randomly assigned to a pathway group and control (129 each). The received standard care, while additional assess its effectiveness. Before surgery (T0), there no significant differences between groups in stress response indicators, including body temperature (T), heart rate (HR), blood oxygen saturation (SpO2), glucose...
BACKGROUND Hepatitis B virus (HBV) evades the innate immunity and leads to persistent chronic infection, but molecular mechanism is still not well known. AIM To investigate whether HBV-miR-3 involved in HBV immune evasion. METHODS agomir antagomir were employed verify effectiveness of on cGAS-Sting-IFN pathway through experiments relative luciferase activity, cGAS protein expression, Sting phosphorylation interferon (IFN) production. RESULTS down-regulates expression post-transcriptionally...
As an important anti-HBV drug, pegylated interferon α (PegIFNα) offers promising clinical efficacy, but biomarkers that accurately forecast treatment responses are yet to be elucidated. Here, we evaluated whether HBV RNA could act as early monitor of responses.
HBV-miR-3 is encoded by HBV and takes part in pathogenesis of HBV-related liver disease. Whether has a relationship with replication predictive PegIFN-α treatment response still unknown. quantification based on qRT-PCR. The replication, value were evaluated cohort 650 HBeAg positive patients from multi-center, randomized phase III clinical trial for the study PegIFN-a2b. significantly positively related to HBVDNA, HBVpgRNA, HBsAg at baseline all different time points during treatment. Both...
Although persistent hepatitis B virus (HBV) infection is associated with natural killer (NK) cell dysfunction, it remains obscure whether HBV viral antigens are responsible for NK dysfunction in patients chronic (CHB) infection. In this study, we found that the percentage of cells expressing inhibitory receptor, NKG2A, was increased CHB patients, and NKG2A blockade restored function. Furthermore, frequency positively correlated number regulatory T (Tregs) production interleukin-10 (IL-10)...
Tenofovir alafenamide fumarate has been used in late pregnancy; however, no data exist regarding its safety and effectiveness early middle pregnancy for mothers with hepatitis B virus infection.To design a prospective study to investigate the efficacy of TAF pregnant women chronic HBV infection during early-middle pregnancy.Pregnant active who received tenofovir were enrolled followed up until 6 months postpartum. Infants immunoprophylaxis. The primary endpoint was infants. secondary...
High serum levels of lipopolysaccharide (LPS) with LPS-MD-2/TLR4 complex activated NF-kb and cytokine cause hepatic necrosis in animal models. We investigated the dynamic changes LPS patients acute on chronic hepatitis B liver failure (ACHBLF).We enrolled ACHBLF for a 12-week study. Patients' were measured along 10 healthy controls. Patients supportive care recovered without intervention(s) analyzed. during disease progression phase, peak remission phase compared controls.Among 30 enrolled,...
Hepatitis B surface antigen (HBsAg) clearance is significantly more common in children with chronic hepatitis (CHB) than adults; however, the possible influencing factors related to HBsAg loss have yet be found. This study aimed explore efficacy of long-term interferon (IFN)α therapy treating CHB and analyzed functional cure after treatment.A total 236 aged 1-6 years diagnosed via liver biopsy were included study, all receiving IFNα treatment (IFNα-2b monotherapy, IFNα-2b followed by...
The aim of the present study was to evaluate predictors for advanced liver fibrosis in patients with chronic hepatitis B virus (HBV) infection persistently normal alanine aminotransferase (PNALT), or intermittently mildly elevated ALT (PIEALT). A total 305 were included study. Liver biopsies evaluated using METAVIR scoring system. stiffness (LS) measured Fibroscan. Multivariate logistic regression and area under receiver operating characteristic curve (AUROC) used examine diagnostic value...
The long-term benefits of interferon-α (IFN-α) treatment in children with chronic hepatitis B (CHB) remain unclear. We conducted a retrospective and real-world study to evaluate the safety clearance rates e antigen (HBeAg) surface (HBsAg) CHB who received IFN-α monotherapy for 72 weeks were 13-year follow-up visit. Participants treated (n = 316) more likely become HBeAg negatve (39.87% vs. 27.37%; p < .05) HBsAg negative (11.08% 3.16%; by end period than untreated participants 95). Treated...
Abstract Background This study aimed to describe length of stay (LOS) discharge and site variations among very preterm infants (VPIs) admitted 57 Chinese neonatal intensive care units (NICUs) investigate factors associated with LOS for VPIs. Methods retrospective multicenter cohort enrolled all < 32 weeks’ gestation NICUs which had participated in the Neonatal Network, within 7 days after birth 2019. Exclusion criteria included major congenital anomalies, NICU deaths, against medical...
Abstract Background To investigate the clinical effects of double-dose (4 mg) aflibercept treatment in neovascular age-related macular degeneration (nAMD), compared with standard-dose (2 treatment. Methods A total 108 eyes from 97 patients nAMD and received intravitreal 2 mg and/or 4 were retrospectively reviewed. The changes central thickness (CMT)/ pigmental epithelium detachment height recurrence rate exudation during 12-month follow-up between group group. Self-control comparisons switch...
Objective The aim of this study was to longitudinally evaluate and analyze the role interleukin-22-producing CD4 positive cells (IL-22) in pathogenesis Hepatitis C Virus recurrence after Orthotopic Liver Transplantation (HCV-OLT). Methods 15 HCV-OLT, age- gender- matched non-HCV post-OLT (OLT) hepatitis virus infected (HCV) patients were enrolled into our from liver transplantation research center at Beijing 302 Hospital. We determined frequencies IL-22 using flow cytometry expression mRNA...
Fungal infections are a growing challenge in immunocompromised patients, especially candidiasis. The prolonged use of traditional antifungals to treat Candida infection has caused the emergence drug resistance, fluconazole. Therefore, new therapeutic strategies for warranted. Recently, attention been paid anti-Candida activity antibiotics and their derivatives. Studies revealed that series antibiotics/derivatives displayed potential some them could significantly increase susceptibility...
The association between hepatitis B virus (HBV) quasispecies (QS) and the efficacy of nucleos(t)ide analog therapy is currently not well defined, particularly in case lamivudine (LAM)/adefovir (ADV) combination rescue for patients with chronic HBV infection (CHB) presenting LAM resistance. In present study, 16 CHB rtM204I/V mutation tyrosine-methionine-aspartate-aspartate motif C domain polymerase gene who switched to LAM/ADV treatment due resistance were assessed. DNA was isolated from...
Background Drug-resistant HBV mutants frequently arise during nucleoside/nucleotide analogue (NA) therapy, while the resistance mutations on polymerase also have consequent changes in S protein. The enrichment of immune-escape was negatively correlated with hepatitis B surface antigen (HBsAg) clearance under NA therapy. This study aims to characterize variability and patients virological breakthrough Methods From 2012 2014, serum samples were collected from 156 chronic infection, who had...
To establish a prediction of HBsAg seroconversion in children with chronic hepatitis B (CHB), so as to help clinicians choose therapeutic strategy.A total 63 HBeAg-positive CHB aged 1 17 years, who admitted the fifth medical center Chinese PLA general hospital and treated interferon α (IFNα) 48 weeks were enrolled, clinical data measured. Based on results (HBsAg < 0.05 IU/mL anti-HBsAg > 10 IU/L) at week 48, patients divided into (S) group non-HBsAg (NS) group. Multivariate COX regression...
Knee osteoarthritis (KOA) is the most common knee joint disease. Although KOA belongs to a disease of degeneration cartilage, its pathology involves subchondral bone, meniscus, synovial membrane, articular capsule and other tissue. The infrapatellar fat pad (IPFP), an intracapsular but extrasynovial structure, has some special characteristics endocrine metabolism, then it double roles in development KOA, protective effect much more than harmful effect. Considering IPFP serious complications...
<title>Abstract</title> The apical membrane antigen-1 (AMA-1) is a potential candidate for the development of malaria vaccine targeting Plasmodium parasites. Although studies on immunogenicity AMA-1 are abundant <italic>Plasmodium falciparum</italic> and vivax</italic>, there notable scarcity information malariae</italic>. In this study, we expressed recombinant PmAMA-1 using an <italic>Escherichia coli</italic> expression system. integrity rPmAMA-1 was verified through western blotting...
Abstract Hepatitis B virus (HBV) infection is a global epidemic whose prevention and control among children warrant significant attention. Despite the availability of effective vaccines, disease continues to affect millions worldwide, underscoring need for comprehensive understanding its epidemiology natural history in this vulnerable population. While research on HBV adults has advanced considerably, remains less well-defined may differ from adult studies due unique immunological...
Most of the gastric cancer (GC) worldwide are ascribed to Helicobacter pylori ( H. ) infections, which have a detrimental effect on immunotherapy’s efficacy. Comprehensively dissecting key cell players and molecular pathways associated with immunotherapies is critical for developing novel therapeutic strategies against infection GC. We performed comprehensive single-cell transcriptome analysis nine GC current (HpGC), three previous (ex-HpGC), six without (non-HpGC), healthy controls (HC)....