A5102888797- Hepatitis B Virus Studies
- Head and Neck Surgical Oncology
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Liver physiology and pathology
- Tracheal and airway disorders
- Sinusitis and nasal conditions
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Ear and Head Tumors
- Cancer, Hypoxia, and Metabolism
- Bone Tumor Diagnosis and Treatments
- Liver Disease and Transplantation
- RNA modifications and cancer
- Cleft Lip and Palate Research
- Brain Metastases and Treatment
- Teratomas and Epidermoid Cysts
- Mesenchymal stem cell research
- Craniofacial Disorders and Treatments
Sun Yat-sen University
2015-2025
Third Affiliated Hospital of Sun Yat-sen University
2015-2025
Eye & ENT Hospital of Fudan University
2022-2024
Second Affiliated Hospital of Nanchang University
2019-2024
Nanchang University
2019-2024
Fudan University
2018-2024
Shanghai Medical College of Fudan University
2010-2021
Nanjing Institute of Geography and Limnology
2020
Chinese Academy of Sciences
2020
Office of Infectious Diseases
2012
Abstract Background The role of circRNAs in hepatocellular carcinoma (HCC) progression remains unclear. CircPIAS1 (circBase ID: hsa_circ_0007088) was identified as overexpressed HCC cases through bioinformatics analysis. This study aimed to investigate the oncogenic properties and mechanisms circPIAS1 development. Methods Functional analyses were conducted assess circPIAS1’s impact on cell proliferation, migration, ferroptosis. Xenograft mouse models employed evaluate effects tumor growth...
C-C motif chemokine ligand 14 (CCL14) is a promoting the activation of immune cells. However, relationship between CCL14 expression, tumor immunity, and prognosis in Hepatocellular Carcinoma (HCC) remain unclear. expression its influence on were analyzed by ONCOMINE, Tumor Immune Estimation Resource (TIMER) Kaplan-Meier plotter. The immunity TIMER Gene Expression Profiling Interactive Analysis (GEPIA). was significantly lower several human cancers, including HCC, than corresponding normal...
A growing body of evidence suggests that E2Fs, by regulating gene expression related to cell cycle progression and other cellular processes, play a pivotal role in human cancer. However, the distinct roles each E2F development treatment hepatocellular carcinoma (HCC) remain unknown. In present study, mRNA prognostic value different E2Fs HCC are analyzed.Transcriptional survival data patients with were obtained through ONCOMINE UALCAN databases. Survival analysis plots drawn Kaplan-Meier...
Tuberculosis (TB) and chronic Hepatitis B virus (HBV) infection are common in China. Fist-line anti-TB medications often produce drug-induced liver injury (DILI). This study sought to investigate whether TB patients with HBV co-infection more susceptible failure poor outcomes during treatment.Eighty-four developed DILI treatment were enrolled, including 58 (TB-HBV group) 26 mono-infection (TB group). Clinical data demographic characteristics reviewed. The severity of incidences death...
Dendritic cells are the most potent antigen-presenting in immune therapeutic approaches for chronic hepatitis B (CHB) infection. Here, we developed a clinical trial to evaluate efficacy and safety of autologous HBV vaccine-pulsed DCs their induced T (HPDCT) CHB patients. This was randomised, prospective, open-label, multicentre, superiority study 309 treatment-naive patients were divided into HPDCT plus nucleos(t)ide analogues (NAs) group (n = 84), NAs mono-therapy 82), Peg-interferon...
This consensus will introduce the characteristics of fillers used in surgical cavities domestic nasal surgery patients based on relevant literature and expert opinions. It also provide recommendations for selection cavity different diseases, with chronic sinusitis as a representative example.
Uncontrolled hepatic immunoactivation is regarded as the primary pathological mechanism of fulminant failure (FHF). The major acute-phase mediators associated with FHF, including IL-1β, IL-6, and TNF-α, impair regeneration liver cells stem cell grafts. Amniotic-fluid-derived mesenchymal (AF-MSCs) have capacity, under specific conditions, to differentiate into hepatocytes. Interleukin-1-receptor antagonist (IL-1Ra) plays an anti-inflammatory anti-apoptotic role in acute chronic inflammation,...
Transnasal endoscopic nasopharyngectomy (TEN) has become increasingly used for recurrent nasopharyngeal carcinoma (rNPC); however, there is no report on the definitive resectable contour TEN according to latest staging system carcinoma. The aim of this study was establish types rNPC.A total 101 rNPC patients underwent from January 2016 April 2019 at authors' institution. categorized into four types, which included type I (n=40) with resection nasopharynx and sinuses; II (n=10) lateral...
Background This study aimed to investigate the demographics, treatment outcomes, and prognostic factors of salvage endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma (NPC). Methods We conducted a retrospective analysis 189 patients who underwent for NPC from January 2006 June 2018. The Kaplan–Meier method log-rank test were used assess survival rates. A Cox regression model was multivariate analyses. Results included 132 men 57 women study, with median age 51 (range, 25–85)...
Osteosarcoma is the most common primary malignant bone tumor, but its pathogenesis remains unclear. Ubiquitin-specific processing peptidase 22 (USP22) reported to be highly expressed and associated with tumor malignancy prognosis in cancers. However, role mechanism of USP22 osteosarcoma not fully understood. This study aims investigate function potential using bioinformatics analysis combined experimental validation.
High serum levels of lipopolysaccharide (LPS) with LPS-MD-2/TLR4 complex activated NF-kb and cytokine cause hepatic necrosis in animal models. We investigated the dynamic changes LPS patients acute on chronic hepatitis B liver failure (ACHBLF).We enrolled ACHBLF for a 12-week study. Patients' were measured along 10 healthy controls. Patients supportive care recovered without intervention(s) analyzed. during disease progression phase, peak remission phase compared controls.Among 30 enrolled,...
Hepatitis B virus (HBV) replicates non-cytopathically in the hepatocytes and HBV-related diseases are caused by immune-mediated inflammatory events. This study aimed to identify relationship between clinical-virological characteristics immunity untreated chronic hepatitis (CHB) patients. A total of 209 CHB patients were categorized into immune tolerant (IT, n = 17), inactive carrier (IC, 20), active (IA, 120), gray zone (GZ, 72) phases. The quantitative surface antigen (qHBsAg), e (HBeAg),...
Although patients with liver failure exhibit a generalized inflammatory-imbalance status, substantial evidence indicates that this immunosuppressive or anti-inflammatory state may be deleterious. Increased expression of CD163 (known to involved in several functions the immune system) is significantly correlated fatal outcome. However, little known regulatory mechanisms influence CD163. We assessed on monocytes from both circulating cells and tissues hepatitis B induced using flow cytometry...
Abstract Background and Aim Hepatitis B virus (HBV) load antigens are related to the innate adaptive immunity of chronic hepatitis (CHB) patients. As a new HBV biomarker, role pregenomic RNA (pgRNA) in host is not known. This study aimed identify relationship between serum pgRNA CHB Methods Two hundred twenty‐five treatment‐naïve patients were enrolled. Serum cytokines measured by cytokine antibody array (Luminex multiplex platform). Th1 (T‐helper cell, Th) Th2 cells tested flow cytometry....
There is limited information on innate immunity, especially natural killer (NK) cell function, in different chronic hepatitis B (CHB) stages. Therefore, we examined whether the clinical staging strategy accurately reflects veritable NK immunity. A total of 237 eligible CHB patients and 22 healthy controls were enrolled our study. Demographic data collected, phases (immune active-IA, immune tolerant phase-IT, inactive CHB-IC, grey zone-GZ) classified according to latest American Association...
Salvage endoscopic nasopharyngectomy has better survival prognosis and fewer complications in the management of early stage rNPC, compared to re-irradiation. However, treatment modality advanced recurrent nasopharyngeal carcinoma (rNPC) remains controversial. Thus, purpose this study was investigate demographics, clinical outcomes, prognostic factors associated with salvage rNPC.This conducted a retrospective analysis rNPC patients who underwent surgery betweenm January 2014 December 2019....
Abstract Osteosarcoma (OS) is a malignant bone sarcoma arising from mesenchymal stem cells. The biological role of Acyl-CoA synthetase long-chain family member 4 (ACSL4), recently identified as an oncogene in numerous tumor types, remains largely unclear OS. In this study, we investigated the expression ACSL4 OS tissues using immunohistochemistry staining (IHC) human tissue microarray and cells by qPCR assay. Our findings revealed significant up-regulation both To further understand its...
Health-care workers' (HCWs) exposure to bodily fluids puts them at risk of hepatitis B virus HBV infection. This study investigated vaccination practices and outcomes in HCWs assessed postvaccination seroprotection across different departments.A survey a Chinese public general hospital was carried out with retrospective cohort 1420 (458 males 962 females). status (10-μg/dose used) the from records period 1988 2008. Blood samples were collected tested for surface antigen (HBsAg) antibodies...