A5100677928- Birth, Development, and Health
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Hormonal Regulation and Hypertension
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Acute Ischemic Stroke Management
- Sodium Intake and Health
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Neuroendocrine regulation and behavior
- Venous Thromboembolism Diagnosis and Management
- Renin-Angiotensin System Studies
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Cancer therapeutics and mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic factors in colorectal cancer
- Nitric Oxide and Endothelin Effects
- Esophageal Cancer Research and Treatment
- Gestational Diabetes Research and Management
- Caveolin-1 and cellular processes
- Colorectal and Anal Carcinomas
Soochow University
2024-2025
Anhui Medical University
2023-2025
Hefei Institutes of Physical Science
2023-2025
Chinese Academy of Sciences
2023-2025
Nanchang University
2023
Second Affiliated Hospital of Nanchang University
2023
Jining Medical University
2023
Sun Yat-sen University
2017-2022
Third Affiliated Hospital of Sun Yat-sen University
2017-2022
Army Medical University
2015-2021
With China's rapid economic development, the disease burden may have changed in country. We studied major causes of death and modifiable risk factors a nationally representative cohort 169,871 men women 40 years age older China.Baseline data on participants' demographic characteristics, medical history, lifestyle-related factors, blood pressure, body weight were obtained 1991 with use standard protocol. The follow-up evaluation was conducted 1999 2000, rate 93.4 percent.We documented 20,033...
Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with hierarchy of differentiation states. Recent studies support existence cancer stem cells in that are functionally defined by their capacity for extensive self-renewal and formation secondary tumors phenocopy original tumors. As c-Myc oncoprotein has recognized roles normal cell biology, we hypothesized may contribute to biology as these share characteristics cells.Based on previous...
Glioblastomas are the most common and lethal primary brain tumor. Recent studies implicate an important role for a restricted population of neoplastic cells (glioma stem (GSCs)) in glioma maintenance recurrence. We now demonstrate that GSCs preferentially express two interleukin 6 (IL6) receptors: IL6 receptor alpha (IL6R alpha) glycoprotein 130 (gp130). Targeting IL6R or ligand expression with use short hairpin RNAs (shRNAs) significantly reduces growth neurosphere formation capacity while...
Background Exercise is a major nonpharmacological treatment for hypertension, but its underlying mechanisms are still not completely elucidated. Irisin, polypeptide containing 112 amino acids, which secreted mainly by skeletal muscle cells during exercise, exerts protective role in metabolic diseases, such as diabetes mellitus and obesity. Because of the close relationship between irisin we hypothesized that may play regulation blood pressure. Methods Results Blood pressures male...
C-C motif chemokine ligand 14 (CCL14) is a promoting the activation of immune cells. However, relationship between CCL14 expression, tumor immunity, and prognosis in Hepatocellular Carcinoma (HCC) remain unclear. expression its influence on were analyzed by ONCOMINE, Tumor Immune Estimation Resource (TIMER) Kaplan-Meier plotter. The immunity TIMER Gene Expression Profiling Interactive Analysis (GEPIA). was significantly lower several human cancers, including HCC, than corresponding normal...
Given the very substantial heterogeneity of most human cancers, it is likely that cancer therapeutics will be active in only a small fraction any population patients. As such, development new therapeutics, coupled with methods to match therapy individual patient, critical achieving significant gains disease outcome. One such opportunity use expression signatures identify key oncogenic phenotypes can serve not as biomarkers but also means identifying therapeutic compounds might specifically...
G2 and S phase-expressed-1 (GTSE1) regulates G1/S cell cycle transition. It was recently reported to be overexpressed in certain human cancers, but its significance mechanism(s) hepatocellular carcinoma (HCC) remain unknown. Here, we showed preferential GTSE1 upregulation HCC tissues lines that positively correlated with Ki67. knockdown by short hairpin RNA resulted deficient colony-forming ability depleted capabilities of cells migrate invade. Conversely, exogenous overexpression enhanced...
Background Oxidative stress plays an important role in the pathogenesis of hypertension, especially obesity‐related hypertension. The natriuretic and antinatriuretic components renal renin angiotensin system ( RAS ) maintain sodium homeostasis blood pressure. Here, we test hypothesis that increased oxidative leads to imbalance hypertension obese Zucker rats. Methods Results Lean rats received vehicle or tempol, a superoxide dismutase mimetic drinking water for 4 weeks. Compared with...
Introduction EGFR and KRAS mutations are frequently detected in lung adenocarcinoma (LUAD). Tumor mutational signature (TMS) determination is an approach to identify somatic patterns associated with pathogenic factors. In this study, through the analysis of TMS, underlying factors LUAD were traced. Methods This was a retrospective study. TMS from TCGA, OncoSG, MSK datasets determined by two bioinformatics tools, namely “MutationalPatterns” “FitMS” packages. Elevated microsatellite...
Abstract Background Tumor mutational burden (TMB) is one of the most significant predictive biomarkers immunotherapy efficacy in non-small cell lung cancer (NSCLC). Radiomics allows high-throughput extraction and analysis advanced quantitative medical imaging features. This study develops validates a radiomic model for predicting TMB level response to based on CT features NSCLC. Method Pre-operative chest images 127 patients with NSCLC were retrospectively studied. The 3D-Slicer software was...
Abstract Aims Exposure to maternal diabetes is associated with increased prevalence of hypertension in the offspring. The mechanisms underlying prenatal programming remain unclear. Because endoplasmic reticulum (ER) stress plays a key role vascular endothelial dysfunction hypertension, we investigated whether aberrant ER causes and high blood pressure offspring dams diabetes. Methods results Pregnant Sprague-Dawley rats were intraperitoneally injected streptozotocin (35 mg/kg) or citrate...
The tumour suppressor ARF (alternative reading frame) is encoded by the INK4a (inhibitor of cyclin-dependent kinase 4)/ARF locus, which frequently altered in human tumours. binds MDM2 (murine double minute 2) and releases p53 from inhibition MDM2, resulting stabilization, accumulation activation p53. Recently, has been found to associate with other proteins, but, date, little known about ARF-associated proteins that are implicated post-translational regulation activity. Using a yeast...
Epidemiological and experimental studies suggest that maternal diabetes mellitus programs hypertension is associated with impaired sodium excretion in the adult offspring. However, underlying mechanisms are not clear. Because dopamine receptor function involved pathogenesis of hypertension, we hypothesized renal D 1 also offspring mellitus. Maternal was induced by a single intraperitoneal injection streptozotocin (35 mg/kg) to pregnant Sprague-Dawley rats at day 0 gestation. Compared mothers...
Both angiotensin II type 1 receptor (AT1R) and nuclear factor-kappa B (NF-κB) play significant roles in the pathogenesis of hypertension 2 diabetes. However, role NF-κB perpetuating renal AT1 receptors dysfunction remains unclear. The aim present study to determine whether blockade NF-κB, could reverse exaggerated AT1R function, reduce inflammatory state oxidative stress, lower blood pressure Zucker diabetic fatty (ZDF) rats. Pyrrolidine dithiocarbamate (PDTC), a inhibitor (150 mg/kg...
Abstract Environmental temperature plays a role in the variation of blood pressure. Maternal cold stress could affect physiological phenotype offspring, including pressure elevation. In present study, we found that adult offspring dams exposed to have increased systolic and diastolic pressure, decreased urine volume sodium excretion, accompanied by heart rate variability, secondary activity sympathetic nervous system. Renal denervation or adrenergic receptor blockade excretion. The increase...
Background The aim of this study was to investigate the effect long-term low salt diet on blood pressure and its underlying mechanisms.Methods Male Sprague-Dawley (SD) rats were divided into normal group (0.4%) (0.04%). Blood measured with non-invasive tail-cuff method. contractile response isolated mesenteric arteries using a small vessel myograph. effects renal function intrarenal arterial infusion candesartan (10 μg/kg/min), an angiotensin II receptor type 1 (AT1R) antagonist, also...
Long-term treatment with anticoagulants may contribute to osteoporosis. Although unfractionated heparin and rivaroxaban have adverse effects on bone microstructure function in adult rats, the underlying mechanism remains be elucidated. Heparanase (HPSE) fibroblast growth factor (FGF)2 are important signals formation fracture healing. Therefore, present study was designed investigate of expression HPSE FGF2 human osteoblasts. Human osteoblasts were treated (0.5-50 IU/ml) or (0.13‑13 µg/ml)...
Hepatocellular carcinoma (HCC) is a common and deadly cancer worldwide often refractory to chemotherapy due the development of multidrug resistance. Lonafarnib an orally active potent non-peptidomimetic inhibitor farnesyl transferase. Here, using in vitro HCC cell models, we demonstrated that lonafarnib inhibited tumor proliferation reduced activity mitogen-activated protein kinases pathways. In addition, caused G1 S phase arrest through downregulation Cyclin D1, CDK6 SKP2, while it induced...
Deep venous thrombosis is a significant complication following surgery, and associated with high morbidity mortality in adults. The direct factor Xa inhibitor, rivaroxaban, used to prevent thromboembolism patients suffering from trauma joint arthroplasty. present study compared the effects of rivaroxaban heparin on bone microstructure metabolism adult rats.Twenty-four Wistar rats were divided into sham, groups. Rivaroxaban (1.5 mg·kg(-1)·d(-1)) (2 IU·g(-1)·d(-1)) administered for 4 weeks. To...