A5100461391- Chemical Synthesis and Reactions
- RNA modifications and cancer
- Sleep and Wakefulness Research
- Oxidative Organic Chemistry Reactions
- Ferroptosis and cancer prognosis
- Sulfur-Based Synthesis Techniques
- Cancer-related molecular mechanisms research
- Ferrocene Chemistry and Applications
- Chemical Synthesis and Analysis
- Asymmetric Hydrogenation and Catalysis
- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Multicomponent Synthesis of Heterocycles
- Synthesis and characterization of novel inorganic/organometallic compounds
- Renal cell carcinoma treatment
- Axial and Atropisomeric Chirality Synthesis
- Neuroscience and Neuropharmacology Research
- Renal and related cancers
- Organometallic Complex Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Analytical Chemistry and Chromatography
Army Medical University
2018-2024
Sichuan University
2008-2024
Guiyang Medical University
2022-2024
Chongqing University
2023-2024
Daping Hospital
2018-2023
Beijing Technology and Business University
2023
Hebei Medical University
2023
Robert Bosch (Germany)
2023
Army Medical College
2022
Kyoto University
2021
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, precise mechanisms underlying its anesthetic action are still not completely understood. Here authors show that sevoflurane activates cluster of urocortin 1 (UCN1
Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal associated impaired behavioral performance. Although the neural circuitries promoting in stress conditions have been extensively identified, less known about circuit mechanisms constraining prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation GAD2-positive GABAergic neurons midbrain dorsal raphe nucleus (DRN GAD2 ) decreased wakefulness, while...
The mechanism of Ni(0)-catalyzed denitrogenative transannulation 1,2,3-benzotriazin-4(3H)-ones with alkynes to access isoquinolones has been comprehensively studied by a density functional theory (DFT) calculation and control experimental investigation. results indicate that the transformations proceed via sequential nitrogen extrusion, carbometalation, Ni–C bond insertion, reductive elimination process. A frontier molecular orbital (FMO) natural (NBO) analysis reveals advantages...
Epidemiological and experimental studies suggest that maternal diabetes mellitus programs hypertension is associated with impaired sodium excretion in the adult offspring. However, underlying mechanisms are not clear. Because dopamine receptor function involved pathogenesis of hypertension, we hypothesized renal D 1 also offspring mellitus. Maternal was induced by a single intraperitoneal injection streptozotocin (35 mg/kg) to pregnant Sprague-Dawley rats at day 0 gestation. Compared mothers...
High-frequency oscillatory activity in cognition-related neural circuits during wakefulness consistently induces the growth of dendritic spines and axonal terminals. Although these structural changes are essential for cognitive functions, it is hypothesized that if newly expanded structures fail to establish functional connections, they may become superfluous. Sleep believed facilitate reduction such redundant maintain homeostasis. However, mechanisms underlying this pruning process sleep...
Abstract Poly(ethylene glycol) (PEG) is widely used as a water soluble carrier for polymer‐drug conjugates. Herein, we report degradable linear PEG analogs (DPEGs) carrying multifunctional groups. The DPEGs were synthesized by Michael addition based condensation polymerization of dithiols and diacrylates (PEGDA) or dimethacrylates (PEGDMA). They stable at pH 7.4 but quickly degraded 6.0 5.0. Thus, could be drug carriers without concern their retention in the body. made to carry such...
A cascade Michael addition/alkylation reaction between 3-chlorooxindoles and α-cyano chalcones catalyzed using a multifunctional quinine-derived aminoindanol-thiourea substance was investigated. series of spirooxindoles incorporating densely substituted cyclopropane motif were efficiently obtained with moderate to excellent diastereo- enantioselectivity further transformed products versatile structural diversity. Density functional theory (DFT) calculations indicated that the tentative...
An environmentally benign, fast and convenient protocol has been developed for the Michael addition of 1,3-dicarbonyl compounds to β-nitroalkenes in good excellent yields by a grinding method under catalyst- solvent-free conditions.
The autonomic nervous system dysfunction has been reported in up to 76% of stroke patients 7 days after an acute stroke. Heart rate variability (HRV) is one the important indicators reflecting balance sympathetic and parasympathetic nerves. Therefore, we performed a systematic literature review existing on association between heart different types We included studies published last 32 years (1990 2022). electronic databases MEDLINE PubMed were searched. selected research that met inclusion...
Abstract This paper describes a method for the synthesis of 2‐aryl‐2‐hydroxyethyl dithiocarbamates via difunctionalization alkenes involving C−S and C−O bonds formation with tetraalkylthiuram disulfides as functional reagents. The reaction proceeded well under transition‐metal‐free conditions afforded up to 88% yield desired products. Numerous useful groups were tolerated conditions. methodology provides direct approach β‐hydroxy dithiocarbamates, featuring readily available starting...
Abstract In recent years, the flourishing of synthetic methodology studies has provided concise access to numerous molecules with new chemical space. These compounds form a large library unique scaffolds, but their application in hit discovery is not systematically evaluated. this work, we establish methodology-based compound (SMBL), integrated obtained from our researches, as well virtual derivatives significantly larger scale. We screen and identify small-molecule inhibitors interrupt...
The utilization of virtual compound libraries and screening has become a routine method in drug discovery accelerated the research pharmacy translational medicine. With development computer-aided design (CADD), it is essential to incorporate experiments into education medicinal chemistry. Herein, we describe series conducted by undergraduate students, including construction library, molecular docking, acetylcholinesterase inhibitors. Student feedback indicates that are popular with students...
The coupling of arylboroxines with a variety amines, amides, imides and sulfonamides catalyzed by copper salt/EtOH system has been developed. In the absence base or additive corresponding N-arylation products were obtained in moderate to excellent yields.
2<italic>H</italic>-Chromenones and 2-hydroxyl-2<italic>H</italic>-chromenones were synthesized under BPL- PFL-catalyzed domino reactions from the same substrates respectively.